Adeno-associated virus-mediated expression of activated factor V (FVa) for hemophilia phenotypic correction

Adeno-associated virus-mediated expression of activated factor V (FVa) for hemophilia phenotypic correction

Adeno-associated virus (AAV) gene therapy has been successfully applied in hemophilia patients excluding patients with inhibitors. During the coagulation pathway, activated factor V (FVa) functions downstream as a cofactor of activated factor X (FXa) to amplify thrombin generation. We hypothesize th...

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Bibliographic Details
Main Authors: Junjiang Sun, Xiaojing Chen, Zheng Chai, Hongqian Niu, Amanda L. Dobbins, Timothy C. Nichols, Chengwen Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Medicine
Subjects:
hemophilia
AAV (adeno-associated virus)
gene therapy
activated factor V
inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.880763/full

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