A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury
Protein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a SOX9-associated transcriptional network.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15638-6 |
| _version_ | 1818400498728828928 |
|---|---|
| author | Ji Young Kim Yuntao Bai Laura A. Jayne Ralph D. Hector Avinash K. Persaud Su Sien Ong Shreshtha Rojesh Radhika Raj Mei Ji He Ho Feng Sangwoon Chung Rachel E. Cianciolo John W. Christman Moray J. Campbell David S. Gardner Sharyn D. Baker Alex Sparreboom Rajgopal Govindarajan Harpreet Singh Taosheng Chen Ming Poi Katalin Susztak Stuart R. Cobb Navjot Singh Pabla |
| author_facet | Ji Young Kim Yuntao Bai Laura A. Jayne Ralph D. Hector Avinash K. Persaud Su Sien Ong Shreshtha Rojesh Radhika Raj Mei Ji He Ho Feng Sangwoon Chung Rachel E. Cianciolo John W. Christman Moray J. Campbell David S. Gardner Sharyn D. Baker Alex Sparreboom Rajgopal Govindarajan Harpreet Singh Taosheng Chen Ming Poi Katalin Susztak Stuart R. Cobb Navjot Singh Pabla |
| author_sort | Ji Young Kim |
| collection | DOAJ |
| description | Protein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a SOX9-associated transcriptional network. |
| first_indexed | 2024-12-14T07:37:32Z |
| format | Article |
| id | doaj.art-f36413dcdc0f4c47bbdac00ac1a34b20 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:37:32Z |
| publishDate | 2020-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f36413dcdc0f4c47bbdac00ac1a34b202022-12-21T23:11:08ZengNature PortfolioNature Communications2041-17232020-04-0111111510.1038/s41467-020-15638-6A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injuryJi Young Kim0Yuntao Bai1Laura A. Jayne2Ralph D. Hector3Avinash K. Persaud4Su Sien Ong5Shreshtha Rojesh6Radhika Raj7Mei Ji He Ho Feng8Sangwoon Chung9Rachel E. Cianciolo10John W. Christman11Moray J. Campbell12David S. Gardner13Sharyn D. Baker14Alex Sparreboom15Rajgopal Govindarajan16Harpreet Singh17Taosheng Chen18Ming Poi19Katalin Susztak20Stuart R. Cobb21Navjot Singh Pabla22Division of Pharmaceutics & Comprehensive Cancer Center, The Ohio State UniversityDivision of Pharmaceutics & Comprehensive Cancer Center, The Ohio State UniversityDivision of Pharmaceutics & Comprehensive Cancer Center, The Ohio State UniversitySimons Initiative for the Developing Brain & Patrick Wild Centre, Centre for Discovery Brain Sciences, University of EdinburghDivision of Pharmaceutics & Comprehensive Cancer Center, The Ohio State UniversityDepartment of Chemical Biology & Therapeutics, St. Jude Children’s Research HospitalRenal Electrolyte and Hypertension Division, Department of Medicine and Genetics, University of PennsylvaniaDivision of Pharmaceutics & Comprehensive Cancer Center, The Ohio State UniversityDivision of Pharmaceutics & Comprehensive Cancer Center, The Ohio State UniversityPulmonary, Sleep and Critical Care Medicine, Wexner Medical Center, Davis Heart and Lung Research InstituteDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State UniversityPulmonary, Sleep and Critical Care Medicine, Wexner Medical Center, Davis Heart and Lung Research InstituteDivision of Pharmaceutics & Comprehensive Cancer Center, The Ohio State UniversitySchool of Veterinary Medicine and Science, University of NottinghamDivision of Pharmaceutics & Comprehensive Cancer Center, The Ohio State UniversityDivision of Pharmaceutics & Comprehensive Cancer Center, The Ohio State UniversityDivision of Pharmaceutics & Comprehensive Cancer Center, The Ohio State UniversityDepartment of Physiology and Cell Biology and Davis Heart and Lung Research Institute, The Ohio State UniversityDepartment of Chemical Biology & Therapeutics, St. Jude Children’s Research HospitalDivision of Pharmaceutics & Comprehensive Cancer Center, The Ohio State UniversityRenal Electrolyte and Hypertension Division, Department of Medicine and Genetics, University of PennsylvaniaSimons Initiative for the Developing Brain & Patrick Wild Centre, Centre for Discovery Brain Sciences, University of EdinburghDivision of Pharmaceutics & Comprehensive Cancer Center, The Ohio State UniversityProtein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a SOX9-associated transcriptional network.https://doi.org/10.1038/s41467-020-15638-6 |
| spellingShingle | Ji Young Kim Yuntao Bai Laura A. Jayne Ralph D. Hector Avinash K. Persaud Su Sien Ong Shreshtha Rojesh Radhika Raj Mei Ji He Ho Feng Sangwoon Chung Rachel E. Cianciolo John W. Christman Moray J. Campbell David S. Gardner Sharyn D. Baker Alex Sparreboom Rajgopal Govindarajan Harpreet Singh Taosheng Chen Ming Poi Katalin Susztak Stuart R. Cobb Navjot Singh Pabla A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury Nature Communications |
| title | A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury |
| title_full | A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury |
| title_fullStr | A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury |
| title_full_unstemmed | A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury |
| title_short | A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury |
| title_sort | kinome wide screen identifies a cdkl5 sox9 regulatory axis in epithelial cell death and kidney injury |
| url | https://doi.org/10.1038/s41467-020-15638-6 |
| work_keys_str_mv | AT jiyoungkim akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT yuntaobai akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT lauraajayne akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT ralphdhector akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT avinashkpersaud akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT susienong akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT shreshtharojesh akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT radhikaraj akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT meijihehofeng akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT sangwoonchung akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT rachelecianciolo akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT johnwchristman akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT morayjcampbell akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT davidsgardner akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT sharyndbaker akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT alexsparreboom akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT rajgopalgovindarajan akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT harpreetsingh akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT taoshengchen akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT mingpoi akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT katalinsusztak akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT stuartrcobb akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT navjotsinghpabla akinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT jiyoungkim kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT yuntaobai kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT lauraajayne kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT ralphdhector kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT avinashkpersaud kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT susienong kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT shreshtharojesh kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT radhikaraj kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT meijihehofeng kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT sangwoonchung kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT rachelecianciolo kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT johnwchristman kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT morayjcampbell kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT davidsgardner kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT sharyndbaker kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT alexsparreboom kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT rajgopalgovindarajan kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT harpreetsingh kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT taoshengchen kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT mingpoi kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT katalinsusztak kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT stuartrcobb kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury AT navjotsinghpabla kinomewidescreenidentifiesacdkl5sox9regulatoryaxisinepithelialcelldeathandkidneyinjury |