Sniffing Bacteria with a Carbon-Dot Artificial Nose
Highlights Novel artificial nose based upon electrode-deposited carbon dots (C-dots). Significant selectivity and sensitivity determined by “polarity matching” between the C-dots and gas molecules. The C-dot artificial nose facilitates, for the first time, real-time, continuous monitoring of bacteri...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-04-01
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| Series: | Nano-Micro Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40820-021-00610-w |
| _version_ | 1818607400322596864 |
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| author | Nitzan Shauloff Ahiud Morag Karin Yaniv Seema Singh Ravit Malishev Ofra Paz-Tal Lior Rokach Raz Jelinek |
| author_facet | Nitzan Shauloff Ahiud Morag Karin Yaniv Seema Singh Ravit Malishev Ofra Paz-Tal Lior Rokach Raz Jelinek |
| author_sort | Nitzan Shauloff |
| collection | DOAJ |
| description | Highlights Novel artificial nose based upon electrode-deposited carbon dots (C-dots). Significant selectivity and sensitivity determined by “polarity matching” between the C-dots and gas molecules. The C-dot artificial nose facilitates, for the first time, real-time, continuous monitoring of bacterial proliferation and discrimination among bacterial species, both between Gram-positive and Gram-negative bacteria and between specific strains. Machine learning algorithm furnishes excellent predictability both in the case of individual gases and for complex gas mixtures. Abstract Continuous, real-time monitoring and identification of bacteria through detection of microbially emitted volatile molecules are highly sought albeit elusive goals. We introduce an artificial nose for sensing and distinguishing vapor molecules, based upon recording the capacitance of interdigitated electrodes (IDEs) coated with carbon dots (C-dots) exhibiting different polarities. Exposure of the C-dot-IDEs to volatile molecules induced rapid capacitance changes that were intimately dependent upon the polarities of both gas molecules and the electrode-deposited C-dots. We deciphered the mechanism of capacitance transformations, specifically substitution of electrode-adsorbed water by gas molecules, with concomitant changes in capacitance related to both the polarity and dielectric constants of the vapor molecules tested. The C-dot-IDE gas sensor exhibited excellent selectivity, aided by application of machine learning algorithms. The capacitive C-dot-IDE sensor was employed to continuously monitor microbial proliferation, discriminating among bacteria through detection of distinctive “volatile compound fingerprint” for each bacterial species. The C-dot-IDE platform is robust, reusable, readily assembled from inexpensive building blocks and constitutes a versatile and powerful vehicle for gas sensing in general, bacterial monitoring in particular. |
| first_indexed | 2024-12-16T14:26:09Z |
| format | Article |
| id | doaj.art-f36486e792f04f449d6cbf40eca97ec5 |
| institution | Directory Open Access Journal |
| issn | 2311-6706 2150-5551 |
| language | English |
| last_indexed | 2024-12-16T14:26:09Z |
| publishDate | 2021-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nano-Micro Letters |
| spelling | doaj.art-f36486e792f04f449d6cbf40eca97ec52022-12-21T22:28:22ZengSpringerOpenNano-Micro Letters2311-67062150-55512021-04-0113111510.1007/s40820-021-00610-wSniffing Bacteria with a Carbon-Dot Artificial NoseNitzan Shauloff0Ahiud Morag1Karin Yaniv2Seema Singh3Ravit Malishev4Ofra Paz-Tal5Lior Rokach6Raz Jelinek7Department of Chemistry, Ben Gurion University of the NegevDepartment of Chemistry, Ben Gurion University of the NegevDepartment of Biotechnology Engineering, Ben Gurion University of the NegevDepartment of Chemistry, Ben Gurion University of the NegevDepartment of Chemistry, Ben Gurion University of the NegevChemistry Department, Nuclear Research Center, NegevDepartment of Software and Information System Engineering, Ben-Gurion University of the NegevDepartment of Chemistry, Ben Gurion University of the NegevHighlights Novel artificial nose based upon electrode-deposited carbon dots (C-dots). Significant selectivity and sensitivity determined by “polarity matching” between the C-dots and gas molecules. The C-dot artificial nose facilitates, for the first time, real-time, continuous monitoring of bacterial proliferation and discrimination among bacterial species, both between Gram-positive and Gram-negative bacteria and between specific strains. Machine learning algorithm furnishes excellent predictability both in the case of individual gases and for complex gas mixtures. Abstract Continuous, real-time monitoring and identification of bacteria through detection of microbially emitted volatile molecules are highly sought albeit elusive goals. We introduce an artificial nose for sensing and distinguishing vapor molecules, based upon recording the capacitance of interdigitated electrodes (IDEs) coated with carbon dots (C-dots) exhibiting different polarities. Exposure of the C-dot-IDEs to volatile molecules induced rapid capacitance changes that were intimately dependent upon the polarities of both gas molecules and the electrode-deposited C-dots. We deciphered the mechanism of capacitance transformations, specifically substitution of electrode-adsorbed water by gas molecules, with concomitant changes in capacitance related to both the polarity and dielectric constants of the vapor molecules tested. The C-dot-IDE gas sensor exhibited excellent selectivity, aided by application of machine learning algorithms. The capacitive C-dot-IDE sensor was employed to continuously monitor microbial proliferation, discriminating among bacteria through detection of distinctive “volatile compound fingerprint” for each bacterial species. The C-dot-IDE platform is robust, reusable, readily assembled from inexpensive building blocks and constitutes a versatile and powerful vehicle for gas sensing in general, bacterial monitoring in particular.https://doi.org/10.1007/s40820-021-00610-wCarbon dotsBacterial detectionBacterially emitted volatile moleculesCapacitive gas sensorsGas polarity |
| spellingShingle | Nitzan Shauloff Ahiud Morag Karin Yaniv Seema Singh Ravit Malishev Ofra Paz-Tal Lior Rokach Raz Jelinek Sniffing Bacteria with a Carbon-Dot Artificial Nose Nano-Micro Letters Carbon dots Bacterial detection Bacterially emitted volatile molecules Capacitive gas sensors Gas polarity |
| title | Sniffing Bacteria with a Carbon-Dot Artificial Nose |
| title_full | Sniffing Bacteria with a Carbon-Dot Artificial Nose |
| title_fullStr | Sniffing Bacteria with a Carbon-Dot Artificial Nose |
| title_full_unstemmed | Sniffing Bacteria with a Carbon-Dot Artificial Nose |
| title_short | Sniffing Bacteria with a Carbon-Dot Artificial Nose |
| title_sort | sniffing bacteria with a carbon dot artificial nose |
| topic | Carbon dots Bacterial detection Bacterially emitted volatile molecules Capacitive gas sensors Gas polarity |
| url | https://doi.org/10.1007/s40820-021-00610-w |
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