Detection of high risk human papillomavirus cervical infections by the hybrid capture in Asunción, Paraguay
Cervical cancer is the most frequent malignant tumour of women in Latin America being human papillomavirus (HPV) the main cause. The aim of this study was to increase the knowledge about the cervical infections with oncogenic HPV types (HR-HPV) in Asuncion, Paraguay. Two hundred and seventy-two cerv...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
|
| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300009&lng=en&tlng=en |
| _version_ | 1818117222223052800 |
|---|---|
| author | Laura Mendoza Torres Malvina Páez Ariel Insaurralde María Isabel Rodriguez Amalia Castro Elena Kasamatsu |
| author_facet | Laura Mendoza Torres Malvina Páez Ariel Insaurralde María Isabel Rodriguez Amalia Castro Elena Kasamatsu |
| author_sort | Laura Mendoza Torres |
| collection | DOAJ |
| description | Cervical cancer is the most frequent malignant tumour of women in Latin America being human papillomavirus (HPV) the main cause. The aim of this study was to increase the knowledge about the cervical infections with oncogenic HPV types (HR-HPV) in Asuncion, Paraguay. Two hundred and seventy-two cervical samples were analyzed using hybrid capture II assay (HCA II) for HR-HPV. The frequency of HR-HPV in the study group was 44%. HR-HPV was detected in 25% of the women negative for squamous intraepithelial lesions (NSIL), 72% with atypical squamous cells of undetermined significance (ASCUS), 68% with low SIL and 78% with high SIL. A moderate concordance was observed between HCA II assay and cytology (kappa: 0.43 IC95% 0.3 - 0.5). It was detected a high frequency of HR-HPV in women from 11 to 30 years old and in those over 60 years old. The data obtained in this study showed a high frequency of HR-HPV in woman with NSIL and ASCUS, which corroborate that the use of cytology together with HCA II assay for HR-HPV could improve remarkably the efficiency of screening programs of cervical cancer in Paraguay. Furthermore, these findings point out the need for the periodical follow-up of HR-HPV infections in older women. |
| first_indexed | 2024-12-11T04:34:59Z |
| format | Article |
| id | doaj.art-f3677adf3429439691148cabd0f370f7 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-11T04:34:59Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-f3677adf3429439691148cabd0f370f72022-12-22T01:20:46ZengElsevierBrazilian Journal of Infectious Diseases1678-439113320320610.1590/S1413-86702009000300009S1413-86702009000300009Detection of high risk human papillomavirus cervical infections by the hybrid capture in Asunción, ParaguayLaura Mendoza Torres0Malvina Páez1Ariel Insaurralde2María Isabel Rodriguez3Amalia Castro4Elena Kasamatsu5Universidad Nacional de AsunciónUniversidad Nacional de AsunciónUniversidad Nacional de AsunciónUniversidad Nacional de AsunciónUniversidad Nacional de AsunciónUniversidad Nacional de AsunciónCervical cancer is the most frequent malignant tumour of women in Latin America being human papillomavirus (HPV) the main cause. The aim of this study was to increase the knowledge about the cervical infections with oncogenic HPV types (HR-HPV) in Asuncion, Paraguay. Two hundred and seventy-two cervical samples were analyzed using hybrid capture II assay (HCA II) for HR-HPV. The frequency of HR-HPV in the study group was 44%. HR-HPV was detected in 25% of the women negative for squamous intraepithelial lesions (NSIL), 72% with atypical squamous cells of undetermined significance (ASCUS), 68% with low SIL and 78% with high SIL. A moderate concordance was observed between HCA II assay and cytology (kappa: 0.43 IC95% 0.3 - 0.5). It was detected a high frequency of HR-HPV in women from 11 to 30 years old and in those over 60 years old. The data obtained in this study showed a high frequency of HR-HPV in woman with NSIL and ASCUS, which corroborate that the use of cytology together with HCA II assay for HR-HPV could improve remarkably the efficiency of screening programs of cervical cancer in Paraguay. Furthermore, these findings point out the need for the periodical follow-up of HR-HPV infections in older women.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300009&lng=en&tlng=enHigh risk human papillomavirushybrid capture II assaycytology |
| spellingShingle | Laura Mendoza Torres Malvina Páez Ariel Insaurralde María Isabel Rodriguez Amalia Castro Elena Kasamatsu Detection of high risk human papillomavirus cervical infections by the hybrid capture in Asunción, Paraguay Brazilian Journal of Infectious Diseases High risk human papillomavirus hybrid capture II assay cytology |
| title | Detection of high risk human papillomavirus cervical infections by the hybrid capture in Asunción, Paraguay |
| title_full | Detection of high risk human papillomavirus cervical infections by the hybrid capture in Asunción, Paraguay |
| title_fullStr | Detection of high risk human papillomavirus cervical infections by the hybrid capture in Asunción, Paraguay |
| title_full_unstemmed | Detection of high risk human papillomavirus cervical infections by the hybrid capture in Asunción, Paraguay |
| title_short | Detection of high risk human papillomavirus cervical infections by the hybrid capture in Asunción, Paraguay |
| title_sort | detection of high risk human papillomavirus cervical infections by the hybrid capture in asuncion paraguay |
| topic | High risk human papillomavirus hybrid capture II assay cytology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300009&lng=en&tlng=en |
| work_keys_str_mv | AT lauramendozatorres detectionofhighriskhumanpapillomaviruscervicalinfectionsbythehybridcaptureinasuncionparaguay AT malvinapaez detectionofhighriskhumanpapillomaviruscervicalinfectionsbythehybridcaptureinasuncionparaguay AT arielinsaurralde detectionofhighriskhumanpapillomaviruscervicalinfectionsbythehybridcaptureinasuncionparaguay AT mariaisabelrodriguez detectionofhighriskhumanpapillomaviruscervicalinfectionsbythehybridcaptureinasuncionparaguay AT amaliacastro detectionofhighriskhumanpapillomaviruscervicalinfectionsbythehybridcaptureinasuncionparaguay AT elenakasamatsu detectionofhighriskhumanpapillomaviruscervicalinfectionsbythehybridcaptureinasuncionparaguay |