A model of DNA damage response activation at stalled replication forks by SPRTN
The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13610-7 |
| _version_ | 1818997133276086272 |
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| author | Christopher Bruhn Marco Foiani |
| author_facet | Christopher Bruhn Marco Foiani |
| author_sort | Christopher Bruhn |
| collection | DOAJ |
| description | The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks. |
| first_indexed | 2024-12-20T21:40:47Z |
| format | Article |
| id | doaj.art-f367c6151ba84697a0a594a8dd42fb3f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:40:47Z |
| publishDate | 2019-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f367c6151ba84697a0a594a8dd42fb3f2022-12-21T19:25:49ZengNature PortfolioNature Communications2041-17232019-12-011011310.1038/s41467-019-13610-7A model of DNA damage response activation at stalled replication forks by SPRTNChristopher Bruhn0Marco Foiani1IFOM (Istituto FIRC di Oncologia Molecolare)IFOM (Istituto FIRC di Oncologia Molecolare)The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.https://doi.org/10.1038/s41467-019-13610-7 |
| spellingShingle | Christopher Bruhn Marco Foiani A model of DNA damage response activation at stalled replication forks by SPRTN Nature Communications |
| title | A model of DNA damage response activation at stalled replication forks by SPRTN |
| title_full | A model of DNA damage response activation at stalled replication forks by SPRTN |
| title_fullStr | A model of DNA damage response activation at stalled replication forks by SPRTN |
| title_full_unstemmed | A model of DNA damage response activation at stalled replication forks by SPRTN |
| title_short | A model of DNA damage response activation at stalled replication forks by SPRTN |
| title_sort | model of dna damage response activation at stalled replication forks by sprtn |
| url | https://doi.org/10.1038/s41467-019-13610-7 |
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