Diverse Metabolites and Pharmacological Effects from the Basidiomycetes <em>Inonotus hispidus</em>
<i>Inonotus hispidus</i> mushroom is a popular edible and medicinal mushroom with a long history of use. It is well known as a medicinal fungus with various health benefits for its significant anticancer and immunomodulatory activities. Over the last 60 years, secondary metabolites deriv...
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MDPI AG
2022-08-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/8/1097 |
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| author | Zhen-xin Wang Xi-long Feng Chengwei Liu Jin-ming Gao Jianzhao Qi |
| author_facet | Zhen-xin Wang Xi-long Feng Chengwei Liu Jin-ming Gao Jianzhao Qi |
| author_sort | Zhen-xin Wang |
| collection | DOAJ |
| description | <i>Inonotus hispidus</i> mushroom is a popular edible and medicinal mushroom with a long history of use. It is well known as a medicinal fungus with various health benefits for its significant anticancer and immunomodulatory activities. Over the last 60 years, secondary metabolites derived from <i>I. hispidus</i> and their biological activities have been discovered and investigated. Structurally, these compounds are mainly polyphenols and triterpenoids, which have anticancer, anti-inflammatory, antioxidant, antimicrobial, and enzyme inhibitor activities. Here, the secondary metabolites derived from <i>I. hispidus</i> and their activities were systematically and comprehensively classified and summarized, and the biosynthetic pathway of stylylpyrones was deduced and analyzed further. This review contributes to our understanding of <i>I. hispidus</i> and will help with research into natural product chemistry, pharmacology, and the biosynthesis of <i>I. hispidus</i> metabolites. According to this review, <i>I. hispidus</i> could be a promising source of bioactive compounds for health promotion and the development of functional foods. |
| first_indexed | 2024-03-09T04:47:27Z |
| format | Article |
| id | doaj.art-f3684419f7624c7b8cadb478acb7f797 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T04:47:27Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-f3684419f7624c7b8cadb478acb7f7972023-12-03T13:14:52ZengMDPI AGAntibiotics2079-63822022-08-01118109710.3390/antibiotics11081097Diverse Metabolites and Pharmacological Effects from the Basidiomycetes <em>Inonotus hispidus</em>Zhen-xin Wang0Xi-long Feng1Chengwei Liu2Jin-ming Gao3Jianzhao Qi4Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest Agriculture and Forestry University, Yangling 712100, ChinaShaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Life Sciences, Northeast Forestry University, Harbin 150040, ChinaShaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest Agriculture and Forestry University, Yangling 712100, ChinaShaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest Agriculture and Forestry University, Yangling 712100, China<i>Inonotus hispidus</i> mushroom is a popular edible and medicinal mushroom with a long history of use. It is well known as a medicinal fungus with various health benefits for its significant anticancer and immunomodulatory activities. Over the last 60 years, secondary metabolites derived from <i>I. hispidus</i> and their biological activities have been discovered and investigated. Structurally, these compounds are mainly polyphenols and triterpenoids, which have anticancer, anti-inflammatory, antioxidant, antimicrobial, and enzyme inhibitor activities. Here, the secondary metabolites derived from <i>I. hispidus</i> and their activities were systematically and comprehensively classified and summarized, and the biosynthetic pathway of stylylpyrones was deduced and analyzed further. This review contributes to our understanding of <i>I. hispidus</i> and will help with research into natural product chemistry, pharmacology, and the biosynthesis of <i>I. hispidus</i> metabolites. According to this review, <i>I. hispidus</i> could be a promising source of bioactive compounds for health promotion and the development of functional foods.https://www.mdpi.com/2079-6382/11/8/1097<i>Inonotus hispidus</i>natural productbiological activitymedicinal fungi |
| spellingShingle | Zhen-xin Wang Xi-long Feng Chengwei Liu Jin-ming Gao Jianzhao Qi Diverse Metabolites and Pharmacological Effects from the Basidiomycetes <em>Inonotus hispidus</em> Antibiotics <i>Inonotus hispidus</i> natural product biological activity medicinal fungi |
| title | Diverse Metabolites and Pharmacological Effects from the Basidiomycetes <em>Inonotus hispidus</em> |
| title_full | Diverse Metabolites and Pharmacological Effects from the Basidiomycetes <em>Inonotus hispidus</em> |
| title_fullStr | Diverse Metabolites and Pharmacological Effects from the Basidiomycetes <em>Inonotus hispidus</em> |
| title_full_unstemmed | Diverse Metabolites and Pharmacological Effects from the Basidiomycetes <em>Inonotus hispidus</em> |
| title_short | Diverse Metabolites and Pharmacological Effects from the Basidiomycetes <em>Inonotus hispidus</em> |
| title_sort | diverse metabolites and pharmacological effects from the basidiomycetes em inonotus hispidus em |
| topic | <i>Inonotus hispidus</i> natural product biological activity medicinal fungi |
| url | https://www.mdpi.com/2079-6382/11/8/1097 |
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