Genetic profiling of circulating cell‐free DNA from cerebrospinal fluid and paired plasma in ALK‐positive lung cancer with brain metastases

Genetic profiling of circulating cell‐free DNA from cerebrospinal fluid and paired plasma in ALK‐positive lung cancer with brain metastases

Abstract Background This study used next‐generation sequencing (NGS) to investigate the genetic profiles in cerebrospinal fluid (CSF), plasma, and tumor tissue to explore alternative detection methods for anaplastic lymphoma kinase (ALK) rearrangement status and potential resistance mechanisms to AL...

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Bibliographic Details
Main Authors: Liang Shi, Lili Guo, Hong Tao, Qiyi Meng, Li Tong, Junfang Tang, Kun Li, Shucai Zhang, Zhe Liu
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Thoracic Cancer
Subjects:
ALK
brain metastases
cerebrospinal fluid
lung adenocarcinoma
next‐generation sequencing
Online Access:https://doi.org/10.1111/1759-7714.14936

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