Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins
Flaviviridae-caused diseases are a critical, emerging public health problem worldwide. Flaviviridae infections usually cause severe, acute or chronic diseases, such as liver damage and liver cancer resulting from a hepatitis C virus (HCV) infection and high fever and shock caused by yellow fever. Ma...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-10-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/9/10/291 |
| _version_ | 1818990591663407104 |
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| author | Shun Chen Zhen Wu Mingshu Wang Anchun Cheng |
| author_facet | Shun Chen Zhen Wu Mingshu Wang Anchun Cheng |
| author_sort | Shun Chen |
| collection | DOAJ |
| description | Flaviviridae-caused diseases are a critical, emerging public health problem worldwide. Flaviviridae infections usually cause severe, acute or chronic diseases, such as liver damage and liver cancer resulting from a hepatitis C virus (HCV) infection and high fever and shock caused by yellow fever. Many researchers worldwide are investigating the mechanisms by which Flaviviridae cause severe diseases. Flaviviridae can interfere with the host’s innate immunity to achieve their purpose of proliferation. For instance, dengue virus (DENV) NS2A, NS2B3, NS4A, NS4B and NS5; HCV NS2, NS3, NS3/4A, NS4B and NS5A; and West Nile virus (WNV) NS1 and NS4B proteins are involved in immune evasion. This review discusses the interplay between viral non-structural Flaviviridae proteins and relevant host proteins, which leads to the suppression of the host’s innate antiviral immunity. |
| first_indexed | 2024-12-20T19:56:49Z |
| format | Article |
| id | doaj.art-f369f169f3cd467fb5ca8d53bbaca250 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-20T19:56:49Z |
| publishDate | 2017-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f369f169f3cd467fb5ca8d53bbaca2502022-12-21T19:28:09ZengMDPI AGViruses1999-49152017-10-0191029110.3390/v9100291v9100291Innate Immune Evasion Mediated by Flaviviridae Non-Structural ProteinsShun Chen0Zhen Wu1Mingshu Wang2Anchun Cheng3Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, ChinaFlaviviridae-caused diseases are a critical, emerging public health problem worldwide. Flaviviridae infections usually cause severe, acute or chronic diseases, such as liver damage and liver cancer resulting from a hepatitis C virus (HCV) infection and high fever and shock caused by yellow fever. Many researchers worldwide are investigating the mechanisms by which Flaviviridae cause severe diseases. Flaviviridae can interfere with the host’s innate immunity to achieve their purpose of proliferation. For instance, dengue virus (DENV) NS2A, NS2B3, NS4A, NS4B and NS5; HCV NS2, NS3, NS3/4A, NS4B and NS5A; and West Nile virus (WNV) NS1 and NS4B proteins are involved in immune evasion. This review discusses the interplay between viral non-structural Flaviviridae proteins and relevant host proteins, which leads to the suppression of the host’s innate antiviral immunity.https://www.mdpi.com/1999-4915/9/10/291flavivirusHCVnon-structural proteinimmune evasionemergence |
| spellingShingle | Shun Chen Zhen Wu Mingshu Wang Anchun Cheng Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins Viruses flavivirus HCV non-structural protein immune evasion emergence |
| title | Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins |
| title_full | Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins |
| title_fullStr | Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins |
| title_full_unstemmed | Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins |
| title_short | Innate Immune Evasion Mediated by Flaviviridae Non-Structural Proteins |
| title_sort | innate immune evasion mediated by flaviviridae non structural proteins |
| topic | flavivirus HCV non-structural protein immune evasion emergence |
| url | https://www.mdpi.com/1999-4915/9/10/291 |
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