Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging
Evidence for clinically meaningful benefits of transcutaneous vagus nerve stimulation (VNS) has been rapidly accumulating over the past 15 years. This relatively novel non-invasive brain stimulation technique has been applied to a wide range of neuropsychiatric disorders including schizophrenia, ob...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1184051/full |
| _version_ | 1797770434249228288 |
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| author | Erin Trifilio Erin Trifilio Erin Trifilio Destin Shortell Destin Shortell Sarah Olshan Sarah Olshan Alexandria O’Neal Jozee Coyne Jozee Coyne Damon Lamb Damon Lamb Damon Lamb Eric Porges Eric Porges Eric Porges John Williamson John Williamson John Williamson John Williamson |
| author_facet | Erin Trifilio Erin Trifilio Erin Trifilio Destin Shortell Destin Shortell Sarah Olshan Sarah Olshan Alexandria O’Neal Jozee Coyne Jozee Coyne Damon Lamb Damon Lamb Damon Lamb Eric Porges Eric Porges Eric Porges John Williamson John Williamson John Williamson John Williamson |
| author_sort | Erin Trifilio |
| collection | DOAJ |
| description | Evidence for clinically meaningful benefits of transcutaneous vagus nerve stimulation (VNS) has been rapidly accumulating over the past 15 years. This relatively novel non-invasive brain stimulation technique has been applied to a wide range of neuropsychiatric disorders including schizophrenia, obsessive compulsive disorder, panic disorder, post-traumatic stress disorder, bipolar disorder, and Alzheimer’s disease. More recently, non-invasive forms of VNS have allowed for investigations within healthy aging populations. These results offer insight into protocol considerations specific to older adults and how to translate those results into effective clinical trials and, ultimately, effective clinical care. In this review, we characterize the possible mechanisms by which non-invasive VNS may promote healthy aging (e.g., neurotransmitter effects, inflammation regulation, functional connectivity changes), special considerations for applying non-invasive VNS in an older adult population (e.g., vagus nerve changes with age), and how non-invasive VNS may be used in conjunction with existing behavioral interventions (e.g., cognitive behavioral therapy, cognitive training) to promote healthy emotional and cognitive aging. |
| first_indexed | 2024-03-12T21:23:15Z |
| format | Article |
| id | doaj.art-f36b51179cff4145ba1a74e73d3bb996 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-12T21:23:15Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-f36b51179cff4145ba1a74e73d3bb9962023-07-28T13:35:46ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-07-011710.3389/fnins.2023.11840511184051Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain agingErin Trifilio0Erin Trifilio1Erin Trifilio2Destin Shortell3Destin Shortell4Sarah Olshan5Sarah Olshan6Alexandria O’Neal7Jozee Coyne8Jozee Coyne9Damon Lamb10Damon Lamb11Damon Lamb12Eric Porges13Eric Porges14Eric Porges15John Williamson16John Williamson17John Williamson18John Williamson19Center for OCD and Anxiety Related Disorders, Department of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, United StatesBrain Rehabilitation and Research Center, Malcom Randall VAMC, Gainesville, FL, United StatesDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United StatesDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United StatesCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, United StatesBrain Rehabilitation and Research Center, Malcom Randall VAMC, Gainesville, FL, United StatesCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, United StatesCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, United StatesCenter for OCD and Anxiety Related Disorders, Department of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, United StatesBrain Rehabilitation and Research Center, Malcom Randall VAMC, Gainesville, FL, United StatesCenter for OCD and Anxiety Related Disorders, Department of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, United StatesBrain Rehabilitation and Research Center, Malcom Randall VAMC, Gainesville, FL, United StatesCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, United StatesBrain Rehabilitation and Research Center, Malcom Randall VAMC, Gainesville, FL, United StatesDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United StatesCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, United StatesCenter for OCD and Anxiety Related Disorders, Department of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, United StatesBrain Rehabilitation and Research Center, Malcom Randall VAMC, Gainesville, FL, United StatesDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, United StatesCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, United StatesEvidence for clinically meaningful benefits of transcutaneous vagus nerve stimulation (VNS) has been rapidly accumulating over the past 15 years. This relatively novel non-invasive brain stimulation technique has been applied to a wide range of neuropsychiatric disorders including schizophrenia, obsessive compulsive disorder, panic disorder, post-traumatic stress disorder, bipolar disorder, and Alzheimer’s disease. More recently, non-invasive forms of VNS have allowed for investigations within healthy aging populations. These results offer insight into protocol considerations specific to older adults and how to translate those results into effective clinical trials and, ultimately, effective clinical care. In this review, we characterize the possible mechanisms by which non-invasive VNS may promote healthy aging (e.g., neurotransmitter effects, inflammation regulation, functional connectivity changes), special considerations for applying non-invasive VNS in an older adult population (e.g., vagus nerve changes with age), and how non-invasive VNS may be used in conjunction with existing behavioral interventions (e.g., cognitive behavioral therapy, cognitive training) to promote healthy emotional and cognitive aging.https://www.frontiersin.org/articles/10.3389/fnins.2023.1184051/fulltVNSagingvagustranscutaneous vagus nerve stimulationinflammationbrain |
| spellingShingle | Erin Trifilio Erin Trifilio Erin Trifilio Destin Shortell Destin Shortell Sarah Olshan Sarah Olshan Alexandria O’Neal Jozee Coyne Jozee Coyne Damon Lamb Damon Lamb Damon Lamb Eric Porges Eric Porges Eric Porges John Williamson John Williamson John Williamson John Williamson Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging Frontiers in Neuroscience tVNS aging vagus transcutaneous vagus nerve stimulation inflammation brain |
| title | Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging |
| title_full | Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging |
| title_fullStr | Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging |
| title_full_unstemmed | Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging |
| title_short | Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging |
| title_sort | impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging |
| topic | tVNS aging vagus transcutaneous vagus nerve stimulation inflammation brain |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1184051/full |
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