Resistance of gloves and protective clothing materials to permeation of cytostatic solutions
Objectives The objective of the work was to determine the resistance of selected protective clothing and glove materials to permeation of cytostatics such as docetaxel, fluorouracil, and doxorubicin. Material and Methods The following glove materials were used: natural rubber latex (code A), acrylo...
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| Format: | Article |
| Language: | English |
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Nofer Institute of Occupational Medicine
2018-01-01
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| Series: | International Journal of Occupational Medicine and Environmental Health |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/ijomeh/RESISTANCE-OF-GLOVES-AND-PROTECTIVE-CLOTHING-MATERIALS-TO-PERMEATION-OF-CYTOSTATIC,76453,0,2.html |
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| author | Sylwia Krzemińska Małgorzata Pośniak Małgorzata Szewczyńska |
| author_facet | Sylwia Krzemińska Małgorzata Pośniak Małgorzata Szewczyńska |
| author_sort | Sylwia Krzemińska |
| collection | DOAJ |
| description | Objectives
The objective of the work was to determine the resistance of selected protective clothing and glove materials
to permeation of cytostatics such as docetaxel, fluorouracil, and doxorubicin.
Material and Methods
The following
glove materials were used: natural rubber latex (code A), acrylonitrile-butadiene rubber (code B) and chloroprene rubber
(code C). In addition, we tested a layered material composed of a non-woven polyester (PES), a polypropylene (PP) film,
and a non-woven PP used for protective coats (code D). The cytostatics were analyzed by liquid chromatography with
diode array detection. The tested samples were placed in a purpose-built permeation cell modified to be different from
that specified in the standard EN 6529:2001.
Results
The tested materials were characterized by good resistance to solutions
containing 2 out of the 3 selected cytostatics: doxorubicin and 5-fluorouracil, as indicated by a breakthrough time of
over 480 min. Equally high resistance to permeation of the third cytostatic (docetaxel) was exhibited by natural rubber latex,
acrylonitrile-butadiene rubber, and chloroprene rubber. However, docetaxel permeated much more readily through the
clothing layered material, compromising its barrier properties.
Conclusions
It was found that the presence of additional
components in cytostatic preparations accelerated permeation through material samples, thus deteriorating their barrier
properties. Int J Occup Med Environ Health 2018;31(3):341–350 |
| first_indexed | 2024-04-12T18:25:52Z |
| format | Article |
| id | doaj.art-f36cce04b95a4180af94d626f0c7b9c8 |
| institution | Directory Open Access Journal |
| issn | 1232-1087 1896-494X |
| language | English |
| last_indexed | 2024-04-12T18:25:52Z |
| publishDate | 2018-01-01 |
| publisher | Nofer Institute of Occupational Medicine |
| record_format | Article |
| series | International Journal of Occupational Medicine and Environmental Health |
| spelling | doaj.art-f36cce04b95a4180af94d626f0c7b9c82022-12-22T03:21:16ZengNofer Institute of Occupational MedicineInternational Journal of Occupational Medicine and Environmental Health1232-10871896-494X2018-01-0131334135010.13075/ijomeh.1896.0114076453Resistance of gloves and protective clothing materials to permeation of cytostatic solutionsSylwia Krzemińska0Małgorzata Pośniak1Małgorzata Szewczyńska2Central Institute for Labour Protection – National Research Institute, Łódź, Poland (Department of Personal Equipment)Central Institute for Labour Protection – National Research Institute, Warszawa, Poland (Department of Chemical, Biological and Aerosol Hazards)Central Institute for Labour Protection – National Research Institute, Warszawa, Poland (Department of Chemical, Biological and Aerosol Hazards)Objectives The objective of the work was to determine the resistance of selected protective clothing and glove materials to permeation of cytostatics such as docetaxel, fluorouracil, and doxorubicin. Material and Methods The following glove materials were used: natural rubber latex (code A), acrylonitrile-butadiene rubber (code B) and chloroprene rubber (code C). In addition, we tested a layered material composed of a non-woven polyester (PES), a polypropylene (PP) film, and a non-woven PP used for protective coats (code D). The cytostatics were analyzed by liquid chromatography with diode array detection. The tested samples were placed in a purpose-built permeation cell modified to be different from that specified in the standard EN 6529:2001. Results The tested materials were characterized by good resistance to solutions containing 2 out of the 3 selected cytostatics: doxorubicin and 5-fluorouracil, as indicated by a breakthrough time of over 480 min. Equally high resistance to permeation of the third cytostatic (docetaxel) was exhibited by natural rubber latex, acrylonitrile-butadiene rubber, and chloroprene rubber. However, docetaxel permeated much more readily through the clothing layered material, compromising its barrier properties. Conclusions It was found that the presence of additional components in cytostatic preparations accelerated permeation through material samples, thus deteriorating their barrier properties. Int J Occup Med Environ Health 2018;31(3):341–350http://www.journalssystem.com/ijomeh/RESISTANCE-OF-GLOVES-AND-PROTECTIVE-CLOTHING-MATERIALS-TO-PERMEATION-OF-CYTOSTATIC,76453,0,2.htmlpermeationcytostaticprotective materialsdocetaxelfluorouracildoxorubicin |
| spellingShingle | Sylwia Krzemińska Małgorzata Pośniak Małgorzata Szewczyńska Resistance of gloves and protective clothing materials to permeation of cytostatic solutions International Journal of Occupational Medicine and Environmental Health permeation cytostatic protective materials docetaxel fluorouracil doxorubicin |
| title | Resistance of gloves
and protective clothing materials
to permeation of cytostatic solutions |
| title_full | Resistance of gloves
and protective clothing materials
to permeation of cytostatic solutions |
| title_fullStr | Resistance of gloves
and protective clothing materials
to permeation of cytostatic solutions |
| title_full_unstemmed | Resistance of gloves
and protective clothing materials
to permeation of cytostatic solutions |
| title_short | Resistance of gloves
and protective clothing materials
to permeation of cytostatic solutions |
| title_sort | resistance of gloves and protective clothing materials to permeation of cytostatic solutions |
| topic | permeation cytostatic protective materials docetaxel fluorouracil doxorubicin |
| url | http://www.journalssystem.com/ijomeh/RESISTANCE-OF-GLOVES-AND-PROTECTIVE-CLOTHING-MATERIALS-TO-PERMEATION-OF-CYTOSTATIC,76453,0,2.html |
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