Role of ferroptosis pathways in neuroinflammation and neurological disorders: From pathogenesis to treatment
Ferroptosis is a newly discovered non-apoptotic and iron-dependent type of cell death. Ferroptosis mainly takes place owing to the imbalance of anti-oxidation and oxidation in the body. It is regulated via a number of factors and pathways both inside and outside the cell. Ferroptosis is closely link...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402400817X |
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| author | Syam Mohan Hassan A. Alhazmi Rym Hassani Gulrana Khuwaja V.P. Maheshkumar Afaf Aldahish Kumarappan Chidambaram |
| author_facet | Syam Mohan Hassan A. Alhazmi Rym Hassani Gulrana Khuwaja V.P. Maheshkumar Afaf Aldahish Kumarappan Chidambaram |
| author_sort | Syam Mohan |
| collection | DOAJ |
| description | Ferroptosis is a newly discovered non-apoptotic and iron-dependent type of cell death. Ferroptosis mainly takes place owing to the imbalance of anti-oxidation and oxidation in the body. It is regulated via a number of factors and pathways both inside and outside the cell. Ferroptosis is closely linked with brain and various neurological disorders (NDs). In the human body, the brain contains the highest levels of polyunsaturated fatty acids, which are known as lipid peroxide precursors. In addition, there is also a connection of glutathione depletion and lipid peroxidation with NDs. There is growing evidence regarding the possible link between neuroinflammation and multiple NDs, such as Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, and stroke. Recent studies have demonstrated that disruptions of lipid reactive oxygen species (ROS), glutamate excitatory toxicity, iron homeostasis, and various other manifestations linked with ferroptosis can be identified in various neuroinflammation-mediated NDs. It has also been reported that damage-associated molecular pattern molecules including ROS are generated during the events of ferroptosis and can cause glial activation via activating neuroimmune pathways, which subsequently leads to the generation of various inflammatory factors that play a role in various NDs. This review summarizes the regulation pathways of ferroptosis, the link between ferroptosis as well as inflammation in NDs, and the potential of a range of therapeutic agents that can be used to target ferroptosis and inflammation in the treatment of neurological disorders. |
| first_indexed | 2024-03-08T00:12:39Z |
| format | Article |
| id | doaj.art-f36e9db96c624900ae57ab9f4a8602c9 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T00:12:39Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-f36e9db96c624900ae57ab9f4a8602c92024-02-17T06:38:39ZengElsevierHeliyon2405-84402024-02-01103e24786Role of ferroptosis pathways in neuroinflammation and neurological disorders: From pathogenesis to treatmentSyam Mohan0Hassan A. Alhazmi1Rym Hassani2Gulrana Khuwaja3V.P. Maheshkumar4Afaf Aldahish5Kumarappan Chidambaram6Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, Saudi Arabia; Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India; School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India; Corresponding author. Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, Saudi Arabia.Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, Saudi Arabia; Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, Saudi ArabiaDepartment of Mathematics, University College AlDarb, Jazan University, Jazan, Saudi ArabiaDepartment of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, Saudi ArabiaDepartment of Pharmacy, Annamalai University, Annamalai Nagar 608002, Tamil Nadu, IndiaDepartment of Pharmacology and Toxicology, College of Pharmacy, King Khalid University, Abha 61421, Saudi ArabiaDepartment of Pharmacology and Toxicology, College of Pharmacy, King Khalid University, Abha 61421, Saudi ArabiaFerroptosis is a newly discovered non-apoptotic and iron-dependent type of cell death. Ferroptosis mainly takes place owing to the imbalance of anti-oxidation and oxidation in the body. It is regulated via a number of factors and pathways both inside and outside the cell. Ferroptosis is closely linked with brain and various neurological disorders (NDs). In the human body, the brain contains the highest levels of polyunsaturated fatty acids, which are known as lipid peroxide precursors. In addition, there is also a connection of glutathione depletion and lipid peroxidation with NDs. There is growing evidence regarding the possible link between neuroinflammation and multiple NDs, such as Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, and stroke. Recent studies have demonstrated that disruptions of lipid reactive oxygen species (ROS), glutamate excitatory toxicity, iron homeostasis, and various other manifestations linked with ferroptosis can be identified in various neuroinflammation-mediated NDs. It has also been reported that damage-associated molecular pattern molecules including ROS are generated during the events of ferroptosis and can cause glial activation via activating neuroimmune pathways, which subsequently leads to the generation of various inflammatory factors that play a role in various NDs. This review summarizes the regulation pathways of ferroptosis, the link between ferroptosis as well as inflammation in NDs, and the potential of a range of therapeutic agents that can be used to target ferroptosis and inflammation in the treatment of neurological disorders.http://www.sciencedirect.com/science/article/pii/S240584402400817XFerroptosisNeuroinflammationApoptosisAlzheimer's diseasePhytochemicals |
| spellingShingle | Syam Mohan Hassan A. Alhazmi Rym Hassani Gulrana Khuwaja V.P. Maheshkumar Afaf Aldahish Kumarappan Chidambaram Role of ferroptosis pathways in neuroinflammation and neurological disorders: From pathogenesis to treatment Heliyon Ferroptosis Neuroinflammation Apoptosis Alzheimer's disease Phytochemicals |
| title | Role of ferroptosis pathways in neuroinflammation and neurological disorders: From pathogenesis to treatment |
| title_full | Role of ferroptosis pathways in neuroinflammation and neurological disorders: From pathogenesis to treatment |
| title_fullStr | Role of ferroptosis pathways in neuroinflammation and neurological disorders: From pathogenesis to treatment |
| title_full_unstemmed | Role of ferroptosis pathways in neuroinflammation and neurological disorders: From pathogenesis to treatment |
| title_short | Role of ferroptosis pathways in neuroinflammation and neurological disorders: From pathogenesis to treatment |
| title_sort | role of ferroptosis pathways in neuroinflammation and neurological disorders from pathogenesis to treatment |
| topic | Ferroptosis Neuroinflammation Apoptosis Alzheimer's disease Phytochemicals |
| url | http://www.sciencedirect.com/science/article/pii/S240584402400817X |
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