Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis
The Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with life-threatening severe illnesses and a mortality rate of approximately 35%, particularly in patients with underlying comorbidities. A systematic analysis of 637 MERS-CoV cases suggests that diabetes and hypertension are...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-08-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971216311006 |
| _version_ | 1818544395404705792 |
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| author | Alaa Badawi Seung Gwan Ryoo |
| author_facet | Alaa Badawi Seung Gwan Ryoo |
| author_sort | Alaa Badawi |
| collection | DOAJ |
| description | The Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with life-threatening severe illnesses and a mortality rate of approximately 35%, particularly in patients with underlying comorbidities. A systematic analysis of 637 MERS-CoV cases suggests that diabetes and hypertension are equally prevalent in approximately 50% of the patients. Cardiac diseases are present in 30% and obesity in 16% of the cases. These conditions down-regulate the synthesis of proinflammatory cytokines and impair the host's innate and humoral immune systems. In conclusion, protection against MERS-CoV and other respiratory infections can be improved if public health vaccination strategies are tailored to target persons with chronic disorders. |
| first_indexed | 2024-12-11T22:47:56Z |
| format | Article |
| id | doaj.art-f370448e3f2e4e9f9010f30a46d877a8 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-12-11T22:47:56Z |
| publishDate | 2016-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-f370448e3f2e4e9f9010f30a46d877a82022-12-22T00:47:33ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112016-08-0149C12913310.1016/j.ijid.2016.06.015Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysisAlaa Badawi0Seung Gwan Ryoo1Public Health Risk Science Division, Public Health Agency of Canada, 180 Queen Street West, Toronto, ON M5V 3L7, CanadaFaculty of Arts and Science, University of Toronto, Toronto, ON, CanadaThe Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with life-threatening severe illnesses and a mortality rate of approximately 35%, particularly in patients with underlying comorbidities. A systematic analysis of 637 MERS-CoV cases suggests that diabetes and hypertension are equally prevalent in approximately 50% of the patients. Cardiac diseases are present in 30% and obesity in 16% of the cases. These conditions down-regulate the synthesis of proinflammatory cytokines and impair the host's innate and humoral immune systems. In conclusion, protection against MERS-CoV and other respiratory infections can be improved if public health vaccination strategies are tailored to target persons with chronic disorders.http://www.sciencedirect.com/science/article/pii/S1201971216311006Diabetes mellitusCardiovascular diseasesObesityMiddle East respiratory syndrome coronavirus (MERS-CoV)Systematic review |
| spellingShingle | Alaa Badawi Seung Gwan Ryoo Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis International Journal of Infectious Diseases Diabetes mellitus Cardiovascular diseases Obesity Middle East respiratory syndrome coronavirus (MERS-CoV) Systematic review |
| title | Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis |
| title_full | Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis |
| title_fullStr | Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis |
| title_short | Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis |
| title_sort | prevalence of comorbidities in the middle east respiratory syndrome coronavirus mers cov a systematic review and meta analysis |
| topic | Diabetes mellitus Cardiovascular diseases Obesity Middle East respiratory syndrome coronavirus (MERS-CoV) Systematic review |
| url | http://www.sciencedirect.com/science/article/pii/S1201971216311006 |
| work_keys_str_mv | AT alaabadawi prevalenceofcomorbiditiesinthemiddleeastrespiratorysyndromecoronavirusmerscovasystematicreviewandmetaanalysis AT seunggwanryoo prevalenceofcomorbiditiesinthemiddleeastrespiratorysyndromecoronavirusmerscovasystematicreviewandmetaanalysis |