The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis.
BACKGROUND:The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS. OBJECTIVE:To perform a systematic review and meta-a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5313176?pdf=render |
| _version_ | 1818552155046412288 |
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| author | Elena Morandi Radu Tanasescu Rachael E Tarlinton Cris S Constantinescu Weiya Zhang Christopher Tench Bruno Gran |
| author_facet | Elena Morandi Radu Tanasescu Rachael E Tarlinton Cris S Constantinescu Weiya Zhang Christopher Tench Bruno Gran |
| author_sort | Elena Morandi |
| collection | DOAJ |
| description | BACKGROUND:The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS. OBJECTIVE:To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients. METHODS:Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS. Meta-analysis was performed on the HERV-W family. Odds Ratio (OR) and 95% confidence interval (CI) were calculated for association. RESULTS:43 reports were extracted (25 related to HERV-W, 13 to HERV-H, 9 to HERV-K, 5 to HRES-1 and 1 to HER-15 family). The analysis showed an association between expression of all HERV families and MS. For HERV-W, adequate data was available for meta-analysis. Results from meta-analyses of HERV-W were OR = 22.66 (95%CI 6.32 to 81.20) from 4 studies investigating MSRV/HERV-W (MS-associated retrovirus) envelope mRNA in peripheral blood mononuclear cells, OR = 44.11 (95%CI 12.95 to 150.30) from 6 studies of MSRV/HERV-W polymerase mRNA in serum/plasma and OR = 6.00 (95%CI 3.35 to 10.74) from 4 studies of MSRV/HERV-W polymerase mRNA in CSF. CONCLUSIONS:This systematic review and meta-analysis shows an association between expression of HERVs, and in particular the HERV-W family, and MS. |
| first_indexed | 2024-12-12T09:09:29Z |
| format | Article |
| id | doaj.art-f370a1389c6549329fc74ae972ec8c23 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T09:09:29Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f370a1389c6549329fc74ae972ec8c232022-12-22T00:29:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017241510.1371/journal.pone.0172415The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis.Elena MorandiRadu TanasescuRachael E TarlintonCris S ConstantinescuWeiya ZhangChristopher TenchBruno GranBACKGROUND:The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS. OBJECTIVE:To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients. METHODS:Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS. Meta-analysis was performed on the HERV-W family. Odds Ratio (OR) and 95% confidence interval (CI) were calculated for association. RESULTS:43 reports were extracted (25 related to HERV-W, 13 to HERV-H, 9 to HERV-K, 5 to HRES-1 and 1 to HER-15 family). The analysis showed an association between expression of all HERV families and MS. For HERV-W, adequate data was available for meta-analysis. Results from meta-analyses of HERV-W were OR = 22.66 (95%CI 6.32 to 81.20) from 4 studies investigating MSRV/HERV-W (MS-associated retrovirus) envelope mRNA in peripheral blood mononuclear cells, OR = 44.11 (95%CI 12.95 to 150.30) from 6 studies of MSRV/HERV-W polymerase mRNA in serum/plasma and OR = 6.00 (95%CI 3.35 to 10.74) from 4 studies of MSRV/HERV-W polymerase mRNA in CSF. CONCLUSIONS:This systematic review and meta-analysis shows an association between expression of HERVs, and in particular the HERV-W family, and MS.http://europepmc.org/articles/PMC5313176?pdf=render |
| spellingShingle | Elena Morandi Radu Tanasescu Rachael E Tarlinton Cris S Constantinescu Weiya Zhang Christopher Tench Bruno Gran The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis. PLoS ONE |
| title | The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis. |
| title_full | The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis. |
| title_fullStr | The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis. |
| title_full_unstemmed | The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis. |
| title_short | The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis. |
| title_sort | association between human endogenous retroviruses and multiple sclerosis a systematic review and meta analysis |
| url | http://europepmc.org/articles/PMC5313176?pdf=render |
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