The Effect of Melatonin Treatment and Exposure to Continuous Darkness on the Reactivity of Smooth Muscles to Drugs in Rats
Melatonin is the major secretory product of the pineal gland, playing an integral role in numerous metabolic, physiological and behavioral processes. This study represents an attempt to understand the effect of environmental changes on the responses of a selected isolated tissue to pharmacologicall...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2010-06-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/320 |
| _version_ | 1797223896626233344 |
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| author | Estabraq M. Mahdi Hamoudi A. Mosah |
| author_facet | Estabraq M. Mahdi Hamoudi A. Mosah |
| author_sort | Estabraq M. Mahdi |
| collection | DOAJ |
| description |
Melatonin is the major secretory product of the pineal gland, playing an integral role in numerous metabolic, physiological and behavioral processes.
This study represents an attempt to understand the effect of environmental changes on the responses of a selected isolated tissue to pharmacologically
active substances in certain species which may lead to important experimental and clinical implications in future. Twenty male albino wistar rats were divided
into three experimental groups:
Group 1: Control animals, comprising 6 rats were exposed to 12:12 hour light: dark cycle for 4 weeks.
Group 2: Composed of 8 rats, was kept in a dark environment for 4 weeks.
Group 3: Consisted of 6 rats aged 6-7 weeks, subjected to continuous darkness for 2 weeks, at the end of the first week the rats treated daily with s.c melatonin injection at 1.00 p.m. for 7 consecutive days. The result of this study showed that the vas deferens preparation from the third group reacted with significant increase in reactivity to nor-adrenaline and 5-HT than that of control and continuous dark animals.
The limitation of time and shortage of materials may be blamed for the kind and quantity of results obtained and the conclusions made. Therefore, further studies with regard to the exposure period have to be undertaken in future to extensively elaborate on this point.
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| first_indexed | 2024-04-24T13:44:31Z |
| format | Article |
| id | doaj.art-f3719552ffe9461c8a442d58efeb4f43 |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:44:31Z |
| publishDate | 2010-06-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-f3719552ffe9461c8a442d58efeb4f432024-04-04T06:59:09ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2010-06-017110.32947/ajps.v7i1.320The Effect of Melatonin Treatment and Exposure to Continuous Darkness on the Reactivity of Smooth Muscles to Drugs in RatsEstabraq M. Mahdi0Hamoudi A. Mosah1University of BaghdadUniversity of Baghdad Melatonin is the major secretory product of the pineal gland, playing an integral role in numerous metabolic, physiological and behavioral processes. This study represents an attempt to understand the effect of environmental changes on the responses of a selected isolated tissue to pharmacologically active substances in certain species which may lead to important experimental and clinical implications in future. Twenty male albino wistar rats were divided into three experimental groups: Group 1: Control animals, comprising 6 rats were exposed to 12:12 hour light: dark cycle for 4 weeks. Group 2: Composed of 8 rats, was kept in a dark environment for 4 weeks. Group 3: Consisted of 6 rats aged 6-7 weeks, subjected to continuous darkness for 2 weeks, at the end of the first week the rats treated daily with s.c melatonin injection at 1.00 p.m. for 7 consecutive days. The result of this study showed that the vas deferens preparation from the third group reacted with significant increase in reactivity to nor-adrenaline and 5-HT than that of control and continuous dark animals. The limitation of time and shortage of materials may be blamed for the kind and quantity of results obtained and the conclusions made. Therefore, further studies with regard to the exposure period have to be undertaken in future to extensively elaborate on this point. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/320Melatonin, Vas deferens, 5-HT, Nor-adrenaline |
| spellingShingle | Estabraq M. Mahdi Hamoudi A. Mosah The Effect of Melatonin Treatment and Exposure to Continuous Darkness on the Reactivity of Smooth Muscles to Drugs in Rats Al-Mustansiriyah Journal of Pharmaceutical Sciences Melatonin, Vas deferens, 5-HT, Nor-adrenaline |
| title | The Effect of Melatonin Treatment and Exposure to Continuous Darkness on the Reactivity of Smooth Muscles to Drugs in Rats |
| title_full | The Effect of Melatonin Treatment and Exposure to Continuous Darkness on the Reactivity of Smooth Muscles to Drugs in Rats |
| title_fullStr | The Effect of Melatonin Treatment and Exposure to Continuous Darkness on the Reactivity of Smooth Muscles to Drugs in Rats |
| title_full_unstemmed | The Effect of Melatonin Treatment and Exposure to Continuous Darkness on the Reactivity of Smooth Muscles to Drugs in Rats |
| title_short | The Effect of Melatonin Treatment and Exposure to Continuous Darkness on the Reactivity of Smooth Muscles to Drugs in Rats |
| title_sort | effect of melatonin treatment and exposure to continuous darkness on the reactivity of smooth muscles to drugs in rats |
| topic | Melatonin, Vas deferens, 5-HT, Nor-adrenaline |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/320 |
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