Sarcopenia: assessment of disease burden and strategies to improve outcomes
Ilaria Liguori,1 Gennaro Russo,1 Luisa Aran,1 Giulia Bulli,1 Francesco Curcio,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II&rdq...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2018-05-01
|
| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/sarcopenia-assessment-of-disease-burden-and-strategies-to-improve-outc-peer-reviewed-article-CIA |
| _version_ | 1818744075821514752 |
|---|---|
| author | Liguori I Russo G Aran L Bulli G Curcio F Della-Morte D Gargiulo G Testa G Cacciatore F Bonaduce D Abete P |
| author_facet | Liguori I Russo G Aran L Bulli G Curcio F Della-Morte D Gargiulo G Testa G Cacciatore F Bonaduce D Abete P |
| author_sort | Liguori I |
| collection | DOAJ |
| description | Ilaria Liguori,1 Gennaro Russo,1 Luisa Aran,1 Giulia Bulli,1 Francesco Curcio,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; 2Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 3Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy; 4Division of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy; 5Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 6Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Naples, Italy Abstract: Life expectancy is increasing worldwide, with a resultant increase in the elderly population. Aging is characterized by the progressive loss of skeletal muscle mass and strength – a phenomenon called sarcopenia. Sarcopenia has a complex multifactorial pathogenesis, which involves not only age-related changes in neuromuscular function, muscle protein turnover, and hormone levels and sensitivity, but also a chronic pro-inflammatory state, oxidative stress, and behavioral factors – in particular, nutritional status and degree of physical activity. According to the operational definition by the European Working Group on Sarcopenia in Older People (EWGSOP), the diagnosis of sarcopenia requires the presence of both low muscle mass and low muscle function, which can be defined by low muscle strength or low physical performance. Moreover, biomarkers of sarcopenia have been identified for its early detection and for a detailed identification of the main pathophysiological mechanisms involved in its development. Because sarcopenia is associated with important adverse health outcomes, such as frailty, hospitalization, and mortality, several therapeutic strategies have been identified that involve exercise training, nutritional supplementation, hormonal therapies, and novel strategies and are still under investigation. At the present time, only physical exercise has showed a positive effect in managing and preventing sarcopenia and its adverse health outcomes. Thus, further well-designed and well-conducted studies on sarcopenia are needed. Keywords: sarcopenia, elderly, assessment, therapy |
| first_indexed | 2024-12-18T02:38:33Z |
| format | Article |
| id | doaj.art-f372dd65cece4471bba91ba442d80e9d |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-18T02:38:33Z |
| publishDate | 2018-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-f372dd65cece4471bba91ba442d80e9d2022-12-21T21:23:44ZengDove Medical PressClinical Interventions in Aging1178-19982018-05-01Volume 1391392738272Sarcopenia: assessment of disease burden and strategies to improve outcomesLiguori IRusso GAran LBulli GCurcio FDella-Morte DGargiulo GTesta GCacciatore FBonaduce DAbete PIlaria Liguori,1 Gennaro Russo,1 Luisa Aran,1 Giulia Bulli,1 Francesco Curcio,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; 2Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 3Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy; 4Division of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy; 5Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 6Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Naples, Italy Abstract: Life expectancy is increasing worldwide, with a resultant increase in the elderly population. Aging is characterized by the progressive loss of skeletal muscle mass and strength – a phenomenon called sarcopenia. Sarcopenia has a complex multifactorial pathogenesis, which involves not only age-related changes in neuromuscular function, muscle protein turnover, and hormone levels and sensitivity, but also a chronic pro-inflammatory state, oxidative stress, and behavioral factors – in particular, nutritional status and degree of physical activity. According to the operational definition by the European Working Group on Sarcopenia in Older People (EWGSOP), the diagnosis of sarcopenia requires the presence of both low muscle mass and low muscle function, which can be defined by low muscle strength or low physical performance. Moreover, biomarkers of sarcopenia have been identified for its early detection and for a detailed identification of the main pathophysiological mechanisms involved in its development. Because sarcopenia is associated with important adverse health outcomes, such as frailty, hospitalization, and mortality, several therapeutic strategies have been identified that involve exercise training, nutritional supplementation, hormonal therapies, and novel strategies and are still under investigation. At the present time, only physical exercise has showed a positive effect in managing and preventing sarcopenia and its adverse health outcomes. Thus, further well-designed and well-conducted studies on sarcopenia are needed. Keywords: sarcopenia, elderly, assessment, therapyhttps://www.dovepress.com/sarcopenia-assessment-of-disease-burden-and-strategies-to-improve-outc-peer-reviewed-article-CIAsarcopeniaelderlyassessmenttherapy |
| spellingShingle | Liguori I Russo G Aran L Bulli G Curcio F Della-Morte D Gargiulo G Testa G Cacciatore F Bonaduce D Abete P Sarcopenia: assessment of disease burden and strategies to improve outcomes Clinical Interventions in Aging sarcopenia elderly assessment therapy |
| title | Sarcopenia: assessment of disease burden and strategies to improve outcomes |
| title_full | Sarcopenia: assessment of disease burden and strategies to improve outcomes |
| title_fullStr | Sarcopenia: assessment of disease burden and strategies to improve outcomes |
| title_full_unstemmed | Sarcopenia: assessment of disease burden and strategies to improve outcomes |
| title_short | Sarcopenia: assessment of disease burden and strategies to improve outcomes |
| title_sort | sarcopenia assessment of disease burden and strategies to improve outcomes |
| topic | sarcopenia elderly assessment therapy |
| url | https://www.dovepress.com/sarcopenia-assessment-of-disease-burden-and-strategies-to-improve-outc-peer-reviewed-article-CIA |
| work_keys_str_mv | AT liguorii sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT russog sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT aranl sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT bullig sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT curciof sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT dellamorted sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT gargiulog sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT testag sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT cacciatoref sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT bonaduced sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes AT abetep sarcopeniaassessmentofdiseaseburdenandstrategiestoimproveoutcomes |