The corepressor NCOR1 and OCT4 facilitate early reprogramming by suppressing fibroblast gene expression

The corepressor NCOR1 and OCT4 facilitate early reprogramming by suppressing fibroblast gene expression

Reprogramming somatic cells to induced pluripotent stem cells (iPSC) succeeds only in a small fraction of cells within the population. Reprogramming occurs in distinctive stages, each facing its own bottlenecks. It initiates with overexpression of transcription factors OCT4, SOX2, KLF4 and c-MYC (OS...

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Bibliographic Details
Main Authors: Georgina Peñalosa-Ruiz, Klaas W. Mulder, Gert Jan C. Veenstra
Format: Article
Language:English
Published: PeerJ Inc. 2020-04-01
Series:PeerJ
Subjects:
NCoR or NCOR1
OCT4
Cell identity
Functional genomics
Transcriptional repression
iPS
Online Access:https://peerj.com/articles/8952.pdf

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