Correction of a homoplasmic mitochondrial tRNA mutation in patient-derived iPSCs via a mitochondrial base editor
Abstract Pathogenic mutations in mitochondrial DNA cause severe and often lethal multi-system symptoms in primary mitochondrial defects. However, effective therapies for these defects are still lacking. Strategies such as employing mitochondrially targeted restriction enzymes or programmable nucleas...
Main Authors: | Xiaoxu Chen, Mingyue Chen, Yuqing Zhu, Haifeng Sun, Yue Wang, Yuan Xie, Lianfu Ji, Cheng Wang, Zhibin Hu, Xuejiang Guo, Zhengfeng Xu, Jun Zhang, Shiwei Yang, Dong Liang, Bin Shen |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-11-01
|
Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-023-05500-y |
Similar Items
-
Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs
by: Yi Yang, et al.
Published: (2018-01-01) -
THE HETEROPLASMIC AND HOMOPLASMIC STATES OF MITOCHONDRIAL AND CHLOROPLAST DNA REGIONS IN THE PROGENIES OF WIDE HYBRIDS OF COMMON WHEAT OF DIFFERENT ORIGINS
by: N. V. Trubacheeva, et al.
Published: (2014-12-01) -
Mitochondrial Cardiomyopathy: The Roles of mt-tRNA Mutations
by: Yu Ding, et al.
Published: (2022-10-01) -
Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome.
by: Brittany E Jewell, et al.
Published: (2021-12-01) -
Mitochondrial impairment and synaptic dysfunction are associated with neurological defects in iPSCs-derived cortical neurons of MERRF patients
by: Yu-Ting Wu, et al.
Published: (2023-08-01)