Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study

Abstract Background Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and effectiv...

Full description

Bibliographic Details
Main Authors: Fariba Esmaeili, Masoumeh Zahmatkeshan, Yaser Yousefpoor, Hiva Alipanah, Ehsan Safari, Mahmoud Osanloo
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Online Access:https://doi.org/10.1186/s12906-022-03619-9
_version_ 1818554779233681408
author Fariba Esmaeili
Masoumeh Zahmatkeshan
Yaser Yousefpoor
Hiva Alipanah
Ehsan Safari
Mahmoud Osanloo
author_facet Fariba Esmaeili
Masoumeh Zahmatkeshan
Yaser Yousefpoor
Hiva Alipanah
Ehsan Safari
Mahmoud Osanloo
author_sort Fariba Esmaeili
collection DOAJ
description Abstract Background Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and effectiveness. Methods This study aimed to explore the anti-inflammatory effect (paw edema test) and the anti-nociceptive effect (hot plate and formalin test) of nanoemulsion-based gels containing the essential oils in the animal model. Cinnamon and Clove essential oils nanoemulsions with droplet sizes of 28 ± 6 nm and 12 ± 3 nm were first prepared. By adding carboxymethylcellulose (3.5% w/v), the nanoemulsions were then gelified. Finally, the nanogels were characterized by ATR-FTIR analysis and were used as topical pre-treatment before induction of inflammation or pain in acute and chronic analgesic experimental studies. Results The paw edema and formalin findings showed that the nanogels formulations possess significant anti-nociceptive and anti-inflammatory effects. Conclusion The prepared nanogels could be considered as analgesic drugs for inhibiting the inflammation and pain of diseases.
first_indexed 2024-12-12T09:44:34Z
format Article
id doaj.art-f375455ac80f48638ad1d4911f2dea9d
institution Directory Open Access Journal
issn 2662-7671
language English
last_indexed 2024-12-12T09:44:34Z
publishDate 2022-05-01
publisher BMC
record_format Article
series BMC Complementary Medicine and Therapies
spelling doaj.art-f375455ac80f48638ad1d4911f2dea9d2022-12-22T00:28:27ZengBMCBMC Complementary Medicine and Therapies2662-76712022-05-0122111010.1186/s12906-022-03619-9Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo studyFariba Esmaeili0Masoumeh Zahmatkeshan1Yaser Yousefpoor2Hiva Alipanah3Ehsan Safari4Mahmoud Osanloo5Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical SciencesCellular and Molecular Research Center, Iran University of Medical SciencesResearch Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical SciencesDepartment of Physiology, School of Medicine, Fasa University of Medical SciencesNoncommunicable Disease Research Center, Fasa University of Medical SciencesDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical SciencesAbstract Background Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and effectiveness. Methods This study aimed to explore the anti-inflammatory effect (paw edema test) and the anti-nociceptive effect (hot plate and formalin test) of nanoemulsion-based gels containing the essential oils in the animal model. Cinnamon and Clove essential oils nanoemulsions with droplet sizes of 28 ± 6 nm and 12 ± 3 nm were first prepared. By adding carboxymethylcellulose (3.5% w/v), the nanoemulsions were then gelified. Finally, the nanogels were characterized by ATR-FTIR analysis and were used as topical pre-treatment before induction of inflammation or pain in acute and chronic analgesic experimental studies. Results The paw edema and formalin findings showed that the nanogels formulations possess significant anti-nociceptive and anti-inflammatory effects. Conclusion The prepared nanogels could be considered as analgesic drugs for inhibiting the inflammation and pain of diseases.https://doi.org/10.1186/s12906-022-03619-9AnalgesicsNanomedicinePainkillerPaw edema test
spellingShingle Fariba Esmaeili
Masoumeh Zahmatkeshan
Yaser Yousefpoor
Hiva Alipanah
Ehsan Safari
Mahmoud Osanloo
Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study
BMC Complementary Medicine and Therapies
Analgesics
Nanomedicine
Painkiller
Paw edema test
title Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study
title_full Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study
title_fullStr Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study
title_full_unstemmed Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study
title_short Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study
title_sort anti inflammatory and anti nociceptive effects of cinnamon and clove essential oils nanogels an in vivo study
topic Analgesics
Nanomedicine
Painkiller
Paw edema test
url https://doi.org/10.1186/s12906-022-03619-9
work_keys_str_mv AT faribaesmaeili antiinflammatoryandantinociceptiveeffectsofcinnamonandcloveessentialoilsnanogelsaninvivostudy
AT masoumehzahmatkeshan antiinflammatoryandantinociceptiveeffectsofcinnamonandcloveessentialoilsnanogelsaninvivostudy
AT yaseryousefpoor antiinflammatoryandantinociceptiveeffectsofcinnamonandcloveessentialoilsnanogelsaninvivostudy
AT hivaalipanah antiinflammatoryandantinociceptiveeffectsofcinnamonandcloveessentialoilsnanogelsaninvivostudy
AT ehsansafari antiinflammatoryandantinociceptiveeffectsofcinnamonandcloveessentialoilsnanogelsaninvivostudy
AT mahmoudosanloo antiinflammatoryandantinociceptiveeffectsofcinnamonandcloveessentialoilsnanogelsaninvivostudy