Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study
Abstract Background Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and effectiv...
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Format: | Article |
Language: | English |
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BMC
2022-05-01
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Series: | BMC Complementary Medicine and Therapies |
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Online Access: | https://doi.org/10.1186/s12906-022-03619-9 |
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author | Fariba Esmaeili Masoumeh Zahmatkeshan Yaser Yousefpoor Hiva Alipanah Ehsan Safari Mahmoud Osanloo |
author_facet | Fariba Esmaeili Masoumeh Zahmatkeshan Yaser Yousefpoor Hiva Alipanah Ehsan Safari Mahmoud Osanloo |
author_sort | Fariba Esmaeili |
collection | DOAJ |
description | Abstract Background Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and effectiveness. Methods This study aimed to explore the anti-inflammatory effect (paw edema test) and the anti-nociceptive effect (hot plate and formalin test) of nanoemulsion-based gels containing the essential oils in the animal model. Cinnamon and Clove essential oils nanoemulsions with droplet sizes of 28 ± 6 nm and 12 ± 3 nm were first prepared. By adding carboxymethylcellulose (3.5% w/v), the nanoemulsions were then gelified. Finally, the nanogels were characterized by ATR-FTIR analysis and were used as topical pre-treatment before induction of inflammation or pain in acute and chronic analgesic experimental studies. Results The paw edema and formalin findings showed that the nanogels formulations possess significant anti-nociceptive and anti-inflammatory effects. Conclusion The prepared nanogels could be considered as analgesic drugs for inhibiting the inflammation and pain of diseases. |
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format | Article |
id | doaj.art-f375455ac80f48638ad1d4911f2dea9d |
institution | Directory Open Access Journal |
issn | 2662-7671 |
language | English |
last_indexed | 2024-12-12T09:44:34Z |
publishDate | 2022-05-01 |
publisher | BMC |
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series | BMC Complementary Medicine and Therapies |
spelling | doaj.art-f375455ac80f48638ad1d4911f2dea9d2022-12-22T00:28:27ZengBMCBMC Complementary Medicine and Therapies2662-76712022-05-0122111010.1186/s12906-022-03619-9Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo studyFariba Esmaeili0Masoumeh Zahmatkeshan1Yaser Yousefpoor2Hiva Alipanah3Ehsan Safari4Mahmoud Osanloo5Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical SciencesCellular and Molecular Research Center, Iran University of Medical SciencesResearch Center of Advanced Technologies in Medicine, Torbat Heydariyeh University of Medical SciencesDepartment of Physiology, School of Medicine, Fasa University of Medical SciencesNoncommunicable Disease Research Center, Fasa University of Medical SciencesDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical SciencesAbstract Background Cinnamon (Cinnamomum zeylanicum) and Clove (Syzygium aromaticum) essential oils are two medicinally important plant-derived substances with a wide range of biological properties. Besides, nanoemulsion-based gels have been widely used to increase topical drug delivery and effectiveness. Methods This study aimed to explore the anti-inflammatory effect (paw edema test) and the anti-nociceptive effect (hot plate and formalin test) of nanoemulsion-based gels containing the essential oils in the animal model. Cinnamon and Clove essential oils nanoemulsions with droplet sizes of 28 ± 6 nm and 12 ± 3 nm were first prepared. By adding carboxymethylcellulose (3.5% w/v), the nanoemulsions were then gelified. Finally, the nanogels were characterized by ATR-FTIR analysis and were used as topical pre-treatment before induction of inflammation or pain in acute and chronic analgesic experimental studies. Results The paw edema and formalin findings showed that the nanogels formulations possess significant anti-nociceptive and anti-inflammatory effects. Conclusion The prepared nanogels could be considered as analgesic drugs for inhibiting the inflammation and pain of diseases.https://doi.org/10.1186/s12906-022-03619-9AnalgesicsNanomedicinePainkillerPaw edema test |
spellingShingle | Fariba Esmaeili Masoumeh Zahmatkeshan Yaser Yousefpoor Hiva Alipanah Ehsan Safari Mahmoud Osanloo Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study BMC Complementary Medicine and Therapies Analgesics Nanomedicine Painkiller Paw edema test |
title | Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study |
title_full | Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study |
title_fullStr | Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study |
title_full_unstemmed | Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study |
title_short | Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study |
title_sort | anti inflammatory and anti nociceptive effects of cinnamon and clove essential oils nanogels an in vivo study |
topic | Analgesics Nanomedicine Painkiller Paw edema test |
url | https://doi.org/10.1186/s12906-022-03619-9 |
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