Synthesis, spectroscopic and antimicrobial properties of Co(II), Ni (II) and Cu(II) complexes of (<i>E</i>)-N’-(2-hydroxy -5-nitrobenzylidene)isonicotinohydrazide)
The objective of this study is to investigate the antimicrobial activity of novel Schiff base metal complexes. The resistance of micro-organisms to classical antimicrobial compounds poses a challenge to effective management and treatment of some diseases. In line with this, copper (II), nickel (II)...
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| Format: | Article |
| Language: | English |
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Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)
2017-03-01
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| Series: | Journal of Applied Sciences and Environmental Management |
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| Online Access: | https://www.ajol.info/index.php/jasem/article/view/152752 |
| _version_ | 1797227935932874752 |
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| author | Tolulope M. Fasina Cordelia U. Dueke-Eze F. Nneoma Idika |
| author_facet | Tolulope M. Fasina Cordelia U. Dueke-Eze F. Nneoma Idika |
| author_sort | Tolulope M. Fasina |
| collection | DOAJ |
| description |
The objective of this study is to investigate the antimicrobial activity of novel Schiff base metal complexes. The resistance of micro-organisms to classical antimicrobial compounds poses a challenge to effective management and treatment of some diseases. In line with this, copper (II), nickel (II) and cobalt (II) complexes of the Schiff base ligand (E)-N’-(2- hydroxy-5-nitrobenzylidene) isonicotinohydrazide) were synthesized and characterized based on elemental analysis, conductivity measurements, infrared and electronic absorption spectroscopy. The results suggest a 1:2 [M:L] stoichiometry for the copper and cobalt complexes and a 1:1 [M:L] ratio for the nickel complex. The electronic absorption spectral data support octahedral geometry for cobalt(II) and copper(II) complexes and square planar for nickel (II). In-vitro antimicrobial properties of the compounds evaluated against five pathogenic bacteria using the agar-well diffusion method revealed that the activity was in the order Ni>Co>Cu. These compounds can be used as substrates for development of new antimicrobial agents.
Keywords: isonicotinohydrazide, Schiff base metal complexes, in-vitro, antimicrobial activity, electronic spectra, 2-hydroxy-5-nitrobenzaldehyde
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| first_indexed | 2024-04-24T14:48:43Z |
| format | Article |
| id | doaj.art-f37957d6bcf64ab7acf9d01bdd2fd9ba |
| institution | Directory Open Access Journal |
| issn | 2659-1502 2659-1499 |
| language | English |
| last_indexed | 2024-04-24T14:48:43Z |
| publishDate | 2017-03-01 |
| publisher | Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) |
| record_format | Article |
| series | Journal of Applied Sciences and Environmental Management |
| spelling | doaj.art-f37957d6bcf64ab7acf9d01bdd2fd9ba2024-04-02T19:52:32ZengJoint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP)Journal of Applied Sciences and Environmental Management2659-15022659-14992017-03-0121110.4314/jasem.v21i1.13Synthesis, spectroscopic and antimicrobial properties of Co(II), Ni (II) and Cu(II) complexes of (<i>E</i>)-N’-(2-hydroxy -5-nitrobenzylidene)isonicotinohydrazide)Tolulope M. FasinaCordelia U. Dueke-EzeF. Nneoma Idika The objective of this study is to investigate the antimicrobial activity of novel Schiff base metal complexes. The resistance of micro-organisms to classical antimicrobial compounds poses a challenge to effective management and treatment of some diseases. In line with this, copper (II), nickel (II) and cobalt (II) complexes of the Schiff base ligand (E)-N’-(2- hydroxy-5-nitrobenzylidene) isonicotinohydrazide) were synthesized and characterized based on elemental analysis, conductivity measurements, infrared and electronic absorption spectroscopy. The results suggest a 1:2 [M:L] stoichiometry for the copper and cobalt complexes and a 1:1 [M:L] ratio for the nickel complex. The electronic absorption spectral data support octahedral geometry for cobalt(II) and copper(II) complexes and square planar for nickel (II). In-vitro antimicrobial properties of the compounds evaluated against five pathogenic bacteria using the agar-well diffusion method revealed that the activity was in the order Ni>Co>Cu. These compounds can be used as substrates for development of new antimicrobial agents. Keywords: isonicotinohydrazide, Schiff base metal complexes, in-vitro, antimicrobial activity, electronic spectra, 2-hydroxy-5-nitrobenzaldehyde https://www.ajol.info/index.php/jasem/article/view/152752isonicotinohydrazideSchiff base metal complexesin-vitroantimicrobial activityelectronic spectra2-hydroxy-5-nitrobenzaldehyde |
| spellingShingle | Tolulope M. Fasina Cordelia U. Dueke-Eze F. Nneoma Idika Synthesis, spectroscopic and antimicrobial properties of Co(II), Ni (II) and Cu(II) complexes of (<i>E</i>)-N’-(2-hydroxy -5-nitrobenzylidene)isonicotinohydrazide) Journal of Applied Sciences and Environmental Management isonicotinohydrazide Schiff base metal complexes in-vitro antimicrobial activity electronic spectra 2-hydroxy-5-nitrobenzaldehyde |
| title | Synthesis, spectroscopic and antimicrobial properties of Co(II), Ni (II) and Cu(II) complexes of (<i>E</i>)-N’-(2-hydroxy -5-nitrobenzylidene)isonicotinohydrazide) |
| title_full | Synthesis, spectroscopic and antimicrobial properties of Co(II), Ni (II) and Cu(II) complexes of (<i>E</i>)-N’-(2-hydroxy -5-nitrobenzylidene)isonicotinohydrazide) |
| title_fullStr | Synthesis, spectroscopic and antimicrobial properties of Co(II), Ni (II) and Cu(II) complexes of (<i>E</i>)-N’-(2-hydroxy -5-nitrobenzylidene)isonicotinohydrazide) |
| title_full_unstemmed | Synthesis, spectroscopic and antimicrobial properties of Co(II), Ni (II) and Cu(II) complexes of (<i>E</i>)-N’-(2-hydroxy -5-nitrobenzylidene)isonicotinohydrazide) |
| title_short | Synthesis, spectroscopic and antimicrobial properties of Co(II), Ni (II) and Cu(II) complexes of (<i>E</i>)-N’-(2-hydroxy -5-nitrobenzylidene)isonicotinohydrazide) |
| title_sort | synthesis spectroscopic and antimicrobial properties of co ii ni ii and cu ii complexes of i e i n 2 hydroxy 5 nitrobenzylidene isonicotinohydrazide |
| topic | isonicotinohydrazide Schiff base metal complexes in-vitro antimicrobial activity electronic spectra 2-hydroxy-5-nitrobenzaldehyde |
| url | https://www.ajol.info/index.php/jasem/article/view/152752 |
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