Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence?
Platelet-derived large extracellular vesicles (often referred to as microparticles in the field of cardiovascular disease) have been identified as effector in the atherothrombotic process, therefore representing a target of pharmacological intervention of potential interest. Despite that, limited ev...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.01256/full |
| _version_ | 1828826974637785088 |
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| author | Francesco Taus Alessandra Meneguzzi Marco Castelli Pietro Minuz |
| author_facet | Francesco Taus Alessandra Meneguzzi Marco Castelli Pietro Minuz |
| author_sort | Francesco Taus |
| collection | DOAJ |
| description | Platelet-derived large extracellular vesicles (often referred to as microparticles in the field of cardiovascular disease) have been identified as effector in the atherothrombotic process, therefore representing a target of pharmacological intervention of potential interest. Despite that, limited evidence is so far available concerning the effects of antiplatelet agents on the release of platelet-derived extracellular vesicles. In the present narrative review, the mechanisms leading to vesiculation in platelets and the pathophysiological processes implicated will be discussed. This will be followed by a summary of the present evidence concerning the effects of antiplatelet agents under experimental conditions and in clinical settings. |
| first_indexed | 2024-12-12T14:50:16Z |
| format | Article |
| id | doaj.art-f379d3d9ba3143e0a70f75d8d6d1b688 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T14:50:16Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-f379d3d9ba3143e0a70f75d8d6d1b6882022-12-22T00:21:01ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-11-011010.3389/fphar.2019.01256487202Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence?Francesco TausAlessandra MeneguzziMarco CastelliPietro MinuzPlatelet-derived large extracellular vesicles (often referred to as microparticles in the field of cardiovascular disease) have been identified as effector in the atherothrombotic process, therefore representing a target of pharmacological intervention of potential interest. Despite that, limited evidence is so far available concerning the effects of antiplatelet agents on the release of platelet-derived extracellular vesicles. In the present narrative review, the mechanisms leading to vesiculation in platelets and the pathophysiological processes implicated will be discussed. This will be followed by a summary of the present evidence concerning the effects of antiplatelet agents under experimental conditions and in clinical settings.https://www.frontiersin.org/article/10.3389/fphar.2019.01256/fullplateletsmicrovesiclesaspirinthromboxaneP2Y12 inhibitorsatherothrombosis |
| spellingShingle | Francesco Taus Alessandra Meneguzzi Marco Castelli Pietro Minuz Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence? Frontiers in Pharmacology platelets microvesicles aspirin thromboxane P2Y12 inhibitors atherothrombosis |
| title | Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence? |
| title_full | Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence? |
| title_fullStr | Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence? |
| title_full_unstemmed | Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence? |
| title_short | Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence? |
| title_sort | platelet derived extracellular vesicles as target of antiplatelet agents what is the evidence |
| topic | platelets microvesicles aspirin thromboxane P2Y12 inhibitors atherothrombosis |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.01256/full |
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