Clonidine as an adjuvant to ropivacaine-induced supraclavicular brachial plexus block for upper limb surgeries
Background and Aims: Ropivacaine is a new amide, long acting, pure S-enantiomer, local anesthetic, with differential blocking effect. The addition of clonidine to local anesthetic improves the quality of peripheral nerve blocks. This study was conducted to evaluate the effect of clonidine on charact...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Journal of Anaesthesiology Clinical Pharmacology |
| Subjects: | |
| Online Access: | http://www.joacp.org/article.asp?issn=0970-9185;year=2015;volume=31;issue=3;spage=365;epage=369;aulast=Patil |
| _version_ | 1811241739762008064 |
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| author | Kalyani Nilesh Patil Noopur Dasmit Singh |
| author_facet | Kalyani Nilesh Patil Noopur Dasmit Singh |
| author_sort | Kalyani Nilesh Patil |
| collection | DOAJ |
| description | Background and Aims: Ropivacaine is a new amide, long acting, pure S-enantiomer, local anesthetic, with differential blocking effect. The addition of clonidine to local anesthetic improves the quality of peripheral nerve blocks. This study was conducted to evaluate the effect of clonidine on characteristics of ropivacaine-induced supraclavicular brachial plexus block.
Material and Methods: A total of 60 adult patients were randomly recruited to two groups of 30 each: Group I: 30 ml 0.75% ropivacaine + 1 ml normal saline. Group II: 30 ml 0.75% ropivacaine + 1 mcg/kg clonidine diluted to 1 ml with normal saline.
Results: The onset of sensorimotor block was earlier in Group II (4.36 ± 0.81 min for sensory block and 9.83 ± 1.12 min for motor block) than in Group I (4.84 ± 0.65 min for sensory block and 10.85 ± 0.79 min for motor block). The duration of both sensory and motor block were significantly prolonged by clonidine (P < 0.001). The duration of analgesia was also prolonged in patients receiving clonidine (613.10 ± 51.797 min vs. 878.33 ± 89.955 min). Although incidence of hypotension and bradycardia was higher in Group II when compared to Group I, it was not clinically significant.
Conclusions: Ropivacaine 0.75% is well-tolerated and provides effective surgical anesthesia as well as relief of postoperative pain. Clonidine as an adjuvant to ropivacaine significantly enhances the quality of supraclavicular brachial plexus block by faster onset, prolonged duration of sensory and motor block and improved postoperative analgesia, without associated adverse effects at the dose used. |
| first_indexed | 2024-04-12T13:40:44Z |
| format | Article |
| id | doaj.art-f379da65e72e40d1944bffd3338794fd |
| institution | Directory Open Access Journal |
| issn | 0970-9185 |
| language | English |
| last_indexed | 2024-04-12T13:40:44Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Anaesthesiology Clinical Pharmacology |
| spelling | doaj.art-f379da65e72e40d1944bffd3338794fd2022-12-22T03:30:51ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852015-01-0131336536910.4103/0970-9185.161674Clonidine as an adjuvant to ropivacaine-induced supraclavicular brachial plexus block for upper limb surgeriesKalyani Nilesh PatilNoopur Dasmit SinghBackground and Aims: Ropivacaine is a new amide, long acting, pure S-enantiomer, local anesthetic, with differential blocking effect. The addition of clonidine to local anesthetic improves the quality of peripheral nerve blocks. This study was conducted to evaluate the effect of clonidine on characteristics of ropivacaine-induced supraclavicular brachial plexus block. Material and Methods: A total of 60 adult patients were randomly recruited to two groups of 30 each: Group I: 30 ml 0.75% ropivacaine + 1 ml normal saline. Group II: 30 ml 0.75% ropivacaine + 1 mcg/kg clonidine diluted to 1 ml with normal saline. Results: The onset of sensorimotor block was earlier in Group II (4.36 ± 0.81 min for sensory block and 9.83 ± 1.12 min for motor block) than in Group I (4.84 ± 0.65 min for sensory block and 10.85 ± 0.79 min for motor block). The duration of both sensory and motor block were significantly prolonged by clonidine (P < 0.001). The duration of analgesia was also prolonged in patients receiving clonidine (613.10 ± 51.797 min vs. 878.33 ± 89.955 min). Although incidence of hypotension and bradycardia was higher in Group II when compared to Group I, it was not clinically significant. Conclusions: Ropivacaine 0.75% is well-tolerated and provides effective surgical anesthesia as well as relief of postoperative pain. Clonidine as an adjuvant to ropivacaine significantly enhances the quality of supraclavicular brachial plexus block by faster onset, prolonged duration of sensory and motor block and improved postoperative analgesia, without associated adverse effects at the dose used.http://www.joacp.org/article.asp?issn=0970-9185;year=2015;volume=31;issue=3;spage=365;epage=369;aulast=PatilClonidineropivacinesupraclavicular brachial plexus block |
| spellingShingle | Kalyani Nilesh Patil Noopur Dasmit Singh Clonidine as an adjuvant to ropivacaine-induced supraclavicular brachial plexus block for upper limb surgeries Journal of Anaesthesiology Clinical Pharmacology Clonidine ropivacine supraclavicular brachial plexus block |
| title | Clonidine as an adjuvant to ropivacaine-induced supraclavicular brachial plexus block for upper limb surgeries |
| title_full | Clonidine as an adjuvant to ropivacaine-induced supraclavicular brachial plexus block for upper limb surgeries |
| title_fullStr | Clonidine as an adjuvant to ropivacaine-induced supraclavicular brachial plexus block for upper limb surgeries |
| title_full_unstemmed | Clonidine as an adjuvant to ropivacaine-induced supraclavicular brachial plexus block for upper limb surgeries |
| title_short | Clonidine as an adjuvant to ropivacaine-induced supraclavicular brachial plexus block for upper limb surgeries |
| title_sort | clonidine as an adjuvant to ropivacaine induced supraclavicular brachial plexus block for upper limb surgeries |
| topic | Clonidine ropivacine supraclavicular brachial plexus block |
| url | http://www.joacp.org/article.asp?issn=0970-9185;year=2015;volume=31;issue=3;spage=365;epage=369;aulast=Patil |
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