A Review of Biofilm Formation of <i>Staphylococcus aureus</i> and Its Regulation Mechanism
Bacteria can form biofilms in natural and clinical environments on both biotic and abiotic surfaces. The bacterial aggregates embedded in biofilms are formed by their own produced extracellular matrix. <i>Staphylococcus aureus</i> (<i>S. aureus</i>) is one of the most common...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/1/12 |
| _version_ | 1827629306252099584 |
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| author | Qi Peng Xiaohua Tang Wanyang Dong Ning Sun Wenchang Yuan |
| author_facet | Qi Peng Xiaohua Tang Wanyang Dong Ning Sun Wenchang Yuan |
| author_sort | Qi Peng |
| collection | DOAJ |
| description | Bacteria can form biofilms in natural and clinical environments on both biotic and abiotic surfaces. The bacterial aggregates embedded in biofilms are formed by their own produced extracellular matrix. <i>Staphylococcus aureus</i> (<i>S. aureus</i>) is one of the most common pathogens of biofilm infections. The formation of biofilm can protect bacteria from being attacked by the host immune system and antibiotics and thus bacteria can be persistent against external challenges. Therefore, clinical treatments for biofilm infections are currently encountering difficulty. To address this critical challenge, a new and effective treatment method needs to be developed. A comprehensive understanding of bacterial biofilm formation and regulation mechanisms may provide meaningful insights against antibiotic resistance due to bacterial biofilms. In this review, we discuss an overview of <i>S. aureus</i> biofilms including the formation process, structural and functional properties of biofilm matrix, and the mechanism regulating biofilm formation. |
| first_indexed | 2024-03-09T13:48:40Z |
| format | Article |
| id | doaj.art-f37c3fd624d84bcfbe683b94726043e0 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T13:48:40Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-f37c3fd624d84bcfbe683b94726043e02023-11-30T20:54:29ZengMDPI AGAntibiotics2079-63822022-12-011211210.3390/antibiotics12010012A Review of Biofilm Formation of <i>Staphylococcus aureus</i> and Its Regulation MechanismQi Peng0Xiaohua Tang1Wanyang Dong2Ning Sun3Wenchang Yuan4Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou 510180, ChinaGuangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou 510180, ChinaGuangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou 510180, ChinaGuangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, ChinaGuangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou 510180, ChinaBacteria can form biofilms in natural and clinical environments on both biotic and abiotic surfaces. The bacterial aggregates embedded in biofilms are formed by their own produced extracellular matrix. <i>Staphylococcus aureus</i> (<i>S. aureus</i>) is one of the most common pathogens of biofilm infections. The formation of biofilm can protect bacteria from being attacked by the host immune system and antibiotics and thus bacteria can be persistent against external challenges. Therefore, clinical treatments for biofilm infections are currently encountering difficulty. To address this critical challenge, a new and effective treatment method needs to be developed. A comprehensive understanding of bacterial biofilm formation and regulation mechanisms may provide meaningful insights against antibiotic resistance due to bacterial biofilms. In this review, we discuss an overview of <i>S. aureus</i> biofilms including the formation process, structural and functional properties of biofilm matrix, and the mechanism regulating biofilm formation.https://www.mdpi.com/2079-6382/12/1/12<i>Staphylococcus aureus</i>biofilmsextracellular matrixquorum sensingantibiofilmantibiotic resistance |
| spellingShingle | Qi Peng Xiaohua Tang Wanyang Dong Ning Sun Wenchang Yuan A Review of Biofilm Formation of <i>Staphylococcus aureus</i> and Its Regulation Mechanism Antibiotics <i>Staphylococcus aureus</i> biofilms extracellular matrix quorum sensing antibiofilm antibiotic resistance |
| title | A Review of Biofilm Formation of <i>Staphylococcus aureus</i> and Its Regulation Mechanism |
| title_full | A Review of Biofilm Formation of <i>Staphylococcus aureus</i> and Its Regulation Mechanism |
| title_fullStr | A Review of Biofilm Formation of <i>Staphylococcus aureus</i> and Its Regulation Mechanism |
| title_full_unstemmed | A Review of Biofilm Formation of <i>Staphylococcus aureus</i> and Its Regulation Mechanism |
| title_short | A Review of Biofilm Formation of <i>Staphylococcus aureus</i> and Its Regulation Mechanism |
| title_sort | review of biofilm formation of i staphylococcus aureus i and its regulation mechanism |
| topic | <i>Staphylococcus aureus</i> biofilms extracellular matrix quorum sensing antibiofilm antibiotic resistance |
| url | https://www.mdpi.com/2079-6382/12/1/12 |
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