Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma

Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma

Background and Aims Although both cancer and stellate cells (PSCs) secrete proangiogenic factors, pancreatic cancer is a scirrhous and hypoxic tumor. The impact of cancer-PSCs interactions on angiogenesis was analyzed. Methods Expression of periostin, CD31, and α-smooth muscle actin was assessed by...

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Bibliographic Details
Main Authors:	Mert Erkan, Carolin Reiser-Erkan, Christoph W. Michalski, Stefanie Deucker, Danguole Sauliunaite, Sylvia Streit, Irene Esposito, Helmut Friess, Jörg Kleeff
Format:	Article
Language:	English
Published:	Elsevier 2009-05-01
Series:	Neoplasia: An International Journal for Oncology Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558609800584

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