Ferroptosis of Endothelial Cells in Vascular Diseases
Endothelial cells (ECs) line the inner surface of blood vessels and play a substantial role in vascular biology. Endothelial dysfunction (ED) is strongly correlated with the initiation and progression of many vascular diseases. Regulated cell death, such as ferroptosis, is one of the multiple mechan...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/21/4506 |
| _version_ | 1797466974356242432 |
|---|---|
| author | Hanxu Zhang Shuang Zhou Minxue Sun Manqi Hua Zhiyan Liu Guangyan Mu Zhe Wang Qian Xiang Yimin Cui |
| author_facet | Hanxu Zhang Shuang Zhou Minxue Sun Manqi Hua Zhiyan Liu Guangyan Mu Zhe Wang Qian Xiang Yimin Cui |
| author_sort | Hanxu Zhang |
| collection | DOAJ |
| description | Endothelial cells (ECs) line the inner surface of blood vessels and play a substantial role in vascular biology. Endothelial dysfunction (ED) is strongly correlated with the initiation and progression of many vascular diseases. Regulated cell death, such as ferroptosis, is one of the multiple mechanisms that lead to ED. Ferroptosis is an iron-dependent programmed cell death associated with various vascular diseases, such as cardiovascular, cerebrovascular, and pulmonary vascular diseases. This review summarized ferroptosis of ECs in vascular diseases and discussed potential therapeutic strategies for treating ferroptosis of ECs. In addition to lipid peroxidation inhibitors and iron chelators, a growing body of evidence showed that clinical drugs, natural products, and intervention of noncoding RNAs may also inhibit ferroptosis of ECs. |
| first_indexed | 2024-03-09T18:46:33Z |
| format | Article |
| id | doaj.art-f37fe9bb3c914f32bb3f7abbb5dd29dd |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:46:33Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f37fe9bb3c914f32bb3f7abbb5dd29dd2023-11-24T06:12:35ZengMDPI AGNutrients2072-66432022-10-011421450610.3390/nu14214506Ferroptosis of Endothelial Cells in Vascular DiseasesHanxu Zhang0Shuang Zhou1Minxue Sun2Manqi Hua3Zhiyan Liu4Guangyan Mu5Zhe Wang6Qian Xiang7Yimin Cui8Department of Pharmacy, Peking University First Hospital, Beijing 100034, ChinaDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, ChinaDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, ChinaDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, ChinaDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, ChinaDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, ChinaDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, ChinaDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, ChinaDepartment of Pharmacy, Peking University First Hospital, Beijing 100034, ChinaEndothelial cells (ECs) line the inner surface of blood vessels and play a substantial role in vascular biology. Endothelial dysfunction (ED) is strongly correlated with the initiation and progression of many vascular diseases. Regulated cell death, such as ferroptosis, is one of the multiple mechanisms that lead to ED. Ferroptosis is an iron-dependent programmed cell death associated with various vascular diseases, such as cardiovascular, cerebrovascular, and pulmonary vascular diseases. This review summarized ferroptosis of ECs in vascular diseases and discussed potential therapeutic strategies for treating ferroptosis of ECs. In addition to lipid peroxidation inhibitors and iron chelators, a growing body of evidence showed that clinical drugs, natural products, and intervention of noncoding RNAs may also inhibit ferroptosis of ECs.https://www.mdpi.com/2072-6643/14/21/4506ferroptosisendothelial cellvascular disease |
| spellingShingle | Hanxu Zhang Shuang Zhou Minxue Sun Manqi Hua Zhiyan Liu Guangyan Mu Zhe Wang Qian Xiang Yimin Cui Ferroptosis of Endothelial Cells in Vascular Diseases Nutrients ferroptosis endothelial cell vascular disease |
| title | Ferroptosis of Endothelial Cells in Vascular Diseases |
| title_full | Ferroptosis of Endothelial Cells in Vascular Diseases |
| title_fullStr | Ferroptosis of Endothelial Cells in Vascular Diseases |
| title_full_unstemmed | Ferroptosis of Endothelial Cells in Vascular Diseases |
| title_short | Ferroptosis of Endothelial Cells in Vascular Diseases |
| title_sort | ferroptosis of endothelial cells in vascular diseases |
| topic | ferroptosis endothelial cell vascular disease |
| url | https://www.mdpi.com/2072-6643/14/21/4506 |
| work_keys_str_mv | AT hanxuzhang ferroptosisofendothelialcellsinvasculardiseases AT shuangzhou ferroptosisofendothelialcellsinvasculardiseases AT minxuesun ferroptosisofendothelialcellsinvasculardiseases AT manqihua ferroptosisofendothelialcellsinvasculardiseases AT zhiyanliu ferroptosisofendothelialcellsinvasculardiseases AT guangyanmu ferroptosisofendothelialcellsinvasculardiseases AT zhewang ferroptosisofendothelialcellsinvasculardiseases AT qianxiang ferroptosisofendothelialcellsinvasculardiseases AT yimincui ferroptosisofendothelialcellsinvasculardiseases |