PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells

PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells

PARP-1 inhibition has recently been employed in both mono- and combination therapies in various malignancies including melanoma with both promising and contradicting results reported. Although deeper understanding of the underlying molecular mechanisms may help improving clinical modalities, the com...

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Bibliographic Details
Main Authors: Anna Maria Cseh, Zsolt Fabian, Ruben Quintana-Cabrera, Aliz Szabo, Krisztian Eros, Maria Eugenia Soriano, Ferenc Gallyas, Luca Scorrano, Balazs Sumegi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Physiology
Subjects:
PARP
mitochondria
cancer
melanoma
cell death
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00538/full

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