ROLE OF COMBINED KETOCONAZOLE AND TAMSULOSIN IN SUCCESSFUL TRIAL OF VOIDING WITHOUT CATHETER (TWOC) IN PATIENTS WITH ACUTE URINARY RETENTION DUE TO BENIGN PROSTATIC OBSTRUCTION
Objective: To compare the frequency of patients with successful Trial of voiding without catheter (TWOC) after acute urinary retention secondary to benign prostatic hyperplasia in patients taking ketoconazole and tamsulosin vs tamsulosin alone. Study Design: A randomized controlled trial. Pla...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Army Medical College Rawalpindi
2020-12-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://pafmj.org/index.php/PAFMJ/article/view/3913 |
| _version_ | 1819198582183428096 |
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| author | Muhammad Asim Syed Farhan Ahmed Muhammad Sajid Ali Imran Memon Waqas Memon Muhammad Rashid Kiran Abbas Moiz Ahmed |
| author_facet | Muhammad Asim Syed Farhan Ahmed Muhammad Sajid Ali Imran Memon Waqas Memon Muhammad Rashid Kiran Abbas Moiz Ahmed |
| author_sort | Muhammad Asim |
| collection | DOAJ |
| description | Objective: To compare the frequency of patients with successful Trial of voiding without catheter (TWOC) after acute urinary retention secondary to benign prostatic hyperplasia in patients taking ketoconazole and tamsulosin vs tamsulosin alone.
Study Design: A randomized controlled trial.
Place and Duration: The current study was conducted at Urology Ward, Liaquat National Hospital, Pakistan for a period of six months.
Methodology: A total of 162 patients presenting with acute urinary retention were divided into two groups. Group A received tamsulosin 0.4mg OD and ketoconazole 200mg while Group B received tamsulosin and placebo. Trial of voiding without a catheter was induced after one week of medication. SPSS version 20 was used for data compilation and analysis.
Results: In Group-A, 85.2% of patients were able to void as compared to group B, where only 74.1% of patients were able to void (p<0.05). Successful trial of voiding without catheter was observed in 79.0% and 60.5% in patients of Group-A and Group-B respectively. The association of successful TWOC with the two study groups was found significant (p=0.010).
Conclusion: TWOC in men catheterized for AUR due to BPH was significantly more successful if treated in a combination of ketoconazole and tamsulosin as compared to tamsulosin only. |
| first_indexed | 2024-12-23T03:02:44Z |
| format | Article |
| id | doaj.art-f382075539304f50b98d2e77f34aa313 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-23T03:02:44Z |
| publishDate | 2020-12-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-f382075539304f50b98d2e77f34aa3132022-12-21T18:02:24ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422020-12-0170617231727https://doi.org/10.51253/pafmj.v70i6.39133913ROLE OF COMBINED KETOCONAZOLE AND TAMSULOSIN IN SUCCESSFUL TRIAL OF VOIDING WITHOUT CATHETER (TWOC) IN PATIENTS WITH ACUTE URINARY RETENTION DUE TO BENIGN PROSTATIC OBSTRUCTIONMuhammad Asim0Syed Farhan Ahmed1Muhammad Sajid Ali2Imran Memon3Waqas Memon4Muhammad Rashid5Kiran Abbas6Moiz Ahmed7Dow University of Health Sciences, Karachi PakistanLiaquat National Hospital and Medical College, Karachi PakistanLiaquat National Hospital and Medical College, Karachi PakistanLiaquat National Hospital and Medical College, Karachi PakistanLiaquat National Hospital and Medical College, Karachi PakistanLiaquat National Hospital and Medical College, Karachi PakistanJinnah Postgraduate Medical Center, Karachi PakistanJinnah Postgraduate Medical Center, Karachi PakistanObjective: To compare the frequency of patients with successful Trial of voiding without catheter (TWOC) after acute urinary retention secondary to benign prostatic hyperplasia in patients taking ketoconazole and tamsulosin vs tamsulosin alone. Study Design: A randomized controlled trial. Place and Duration: The current study was conducted at Urology Ward, Liaquat National Hospital, Pakistan for a period of six months. Methodology: A total of 162 patients presenting with acute urinary retention were divided into two groups. Group A received tamsulosin 0.4mg OD and ketoconazole 200mg while Group B received tamsulosin and placebo. Trial of voiding without a catheter was induced after one week of medication. SPSS version 20 was used for data compilation and analysis. Results: In Group-A, 85.2% of patients were able to void as compared to group B, where only 74.1% of patients were able to void (p<0.05). Successful trial of voiding without catheter was observed in 79.0% and 60.5% in patients of Group-A and Group-B respectively. The association of successful TWOC with the two study groups was found significant (p=0.010). Conclusion: TWOC in men catheterized for AUR due to BPH was significantly more successful if treated in a combination of ketoconazole and tamsulosin as compared to tamsulosin only.https://pafmj.org/index.php/PAFMJ/article/view/3913tamsulosinketoconazoleacute urinary retentiontrial without catheterbenign prostatic hyperplasia |
| spellingShingle | Muhammad Asim Syed Farhan Ahmed Muhammad Sajid Ali Imran Memon Waqas Memon Muhammad Rashid Kiran Abbas Moiz Ahmed ROLE OF COMBINED KETOCONAZOLE AND TAMSULOSIN IN SUCCESSFUL TRIAL OF VOIDING WITHOUT CATHETER (TWOC) IN PATIENTS WITH ACUTE URINARY RETENTION DUE TO BENIGN PROSTATIC OBSTRUCTION Pakistan Armed Forces Medical Journal tamsulosin ketoconazole acute urinary retention trial without catheter benign prostatic hyperplasia |
| title | ROLE OF COMBINED KETOCONAZOLE AND TAMSULOSIN IN SUCCESSFUL TRIAL OF VOIDING WITHOUT CATHETER (TWOC) IN PATIENTS WITH ACUTE URINARY RETENTION DUE TO BENIGN PROSTATIC OBSTRUCTION |
| title_full | ROLE OF COMBINED KETOCONAZOLE AND TAMSULOSIN IN SUCCESSFUL TRIAL OF VOIDING WITHOUT CATHETER (TWOC) IN PATIENTS WITH ACUTE URINARY RETENTION DUE TO BENIGN PROSTATIC OBSTRUCTION |
| title_fullStr | ROLE OF COMBINED KETOCONAZOLE AND TAMSULOSIN IN SUCCESSFUL TRIAL OF VOIDING WITHOUT CATHETER (TWOC) IN PATIENTS WITH ACUTE URINARY RETENTION DUE TO BENIGN PROSTATIC OBSTRUCTION |
| title_full_unstemmed | ROLE OF COMBINED KETOCONAZOLE AND TAMSULOSIN IN SUCCESSFUL TRIAL OF VOIDING WITHOUT CATHETER (TWOC) IN PATIENTS WITH ACUTE URINARY RETENTION DUE TO BENIGN PROSTATIC OBSTRUCTION |
| title_short | ROLE OF COMBINED KETOCONAZOLE AND TAMSULOSIN IN SUCCESSFUL TRIAL OF VOIDING WITHOUT CATHETER (TWOC) IN PATIENTS WITH ACUTE URINARY RETENTION DUE TO BENIGN PROSTATIC OBSTRUCTION |
| title_sort | role of combined ketoconazole and tamsulosin in successful trial of voiding without catheter twoc in patients with acute urinary retention due to benign prostatic obstruction |
| topic | tamsulosin ketoconazole acute urinary retention trial without catheter benign prostatic hyperplasia |
| url | https://pafmj.org/index.php/PAFMJ/article/view/3913 |
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