Prediction of diacerein inhibition activity against interleukin-1 receptors through docking method and tracing of pharmacokinetic profiles and their toxicity

Prediction of diacerein inhibition activity against interleukin-1 receptors through docking method and tracing of pharmacokinetic profiles and their toxicity

IL-1 is one of the cytokines involved in joint diseases such as osteoarthritis. IL-1 plays a role in maintaining the balance of proteolytic proteins:MMPs and TIMPs inhibitors. Increased expression and uncontrolled IL-1 activity tend to increase the role of MMPs in degrading proteoglycans and joint t...

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Bibliographic Details
Main Authors: Frengki Frengki, Vivi Sofia, Deddi Prima Putra, Fatma Sri Wahyuni, Daan Khambri, Henni Vanda
Format: Article
Language:English
Published: Universitas Ahmad Dahlan 2020-11-01
Series:Pharmaciana
Subjects:
diacerein
osteoarthritis
il-1
in silico
Online Access:http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/16445/pdf_163

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