Swimming exercise ameliorates insulin resistance and nonalcoholic fatty liver by negatively regulating PPARγ transcriptional network in mice fed high fat diet

Swimming exercise ameliorates insulin resistance and nonalcoholic fatty liver by negatively regulating PPARγ transcriptional network in mice fed high fat diet

Abstract Background Recent findings elucidated hepatic PPARγ functions as a steatogenic-inducer gene that activates de novo lipogenesis, and is involved in regulation of glucose homeostasis, lipid accumulation, and inflammation response. This study delved into a comprehensive analysis of how PPARγ s...

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Bibliographic Details
Main Authors: Yong Zhang, Jie Xu, Di Zhou, Tingting Ye, Puqing Zhou, Zuofeng Liu, Xinyuan Liu, Zinan Wang, Tianmiao Hua, Zhenghao Zhang, Qingyan Sun
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Molecular Medicine
Subjects:
Swimming exercise
Insulin resistance
Non-alcoholic fatty liver disease
PPARγ signaling
Lipid metabolism
Online Access:https://doi.org/10.1186/s10020-023-00740-4

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