Regulation of Gene Expression by Telomere Position Effect
Many diseases that involve malignant tumors in the elderly affect the quality of human life; therefore, the relationship between aging and pathogenesis in geriatric diseases must be under-stood to develop appropriate treatments for these diseases. Recent reports have shown that epigenetic regulation...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/23/12807 |
| _version_ | 1797507820349816832 |
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| author | Kyung-Ha Lee Do-Yeon Kim Wanil Kim |
| author_facet | Kyung-Ha Lee Do-Yeon Kim Wanil Kim |
| author_sort | Kyung-Ha Lee |
| collection | DOAJ |
| description | Many diseases that involve malignant tumors in the elderly affect the quality of human life; therefore, the relationship between aging and pathogenesis in geriatric diseases must be under-stood to develop appropriate treatments for these diseases. Recent reports have shown that epigenetic regulation caused by changes in the local chromatin structure plays an essential role in aging. This review provides an overview of the roles of telomere shortening on genomic structural changes during an age-dependent shift in gene expression. Telomere shortening is one of the most prominent events that is involved in cellular aging and it affects global gene expression through genome rearrangement. This review provides novel insights into the roles of telomere shortening in disease-affected cells during pathogenesis and suggests novel therapeutic approaches. |
| first_indexed | 2024-03-10T04:53:48Z |
| format | Article |
| id | doaj.art-f3838f8c85ba46deb75e3dcba02ba39a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:53:48Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f3838f8c85ba46deb75e3dcba02ba39a2023-11-23T02:28:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122231280710.3390/ijms222312807Regulation of Gene Expression by Telomere Position EffectKyung-Ha Lee0Do-Yeon Kim1Wanil Kim2Division of Cosmetic Science and Technology, Daegu Haany University, Gyeongsan 38610, KoreaDepartment of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, KoreaDepartment of Biochemistry, Department of Convergence Medical Science, Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju 52727, KoreaMany diseases that involve malignant tumors in the elderly affect the quality of human life; therefore, the relationship between aging and pathogenesis in geriatric diseases must be under-stood to develop appropriate treatments for these diseases. Recent reports have shown that epigenetic regulation caused by changes in the local chromatin structure plays an essential role in aging. This review provides an overview of the roles of telomere shortening on genomic structural changes during an age-dependent shift in gene expression. Telomere shortening is one of the most prominent events that is involved in cellular aging and it affects global gene expression through genome rearrangement. This review provides novel insights into the roles of telomere shortening in disease-affected cells during pathogenesis and suggests novel therapeutic approaches.https://www.mdpi.com/1422-0067/22/23/12807telomereaginggene expressiontelomere position effecttelomere looping |
| spellingShingle | Kyung-Ha Lee Do-Yeon Kim Wanil Kim Regulation of Gene Expression by Telomere Position Effect International Journal of Molecular Sciences telomere aging gene expression telomere position effect telomere looping |
| title | Regulation of Gene Expression by Telomere Position Effect |
| title_full | Regulation of Gene Expression by Telomere Position Effect |
| title_fullStr | Regulation of Gene Expression by Telomere Position Effect |
| title_full_unstemmed | Regulation of Gene Expression by Telomere Position Effect |
| title_short | Regulation of Gene Expression by Telomere Position Effect |
| title_sort | regulation of gene expression by telomere position effect |
| topic | telomere aging gene expression telomere position effect telomere looping |
| url | https://www.mdpi.com/1422-0067/22/23/12807 |
| work_keys_str_mv | AT kyunghalee regulationofgeneexpressionbytelomerepositioneffect AT doyeonkim regulationofgeneexpressionbytelomerepositioneffect AT wanilkim regulationofgeneexpressionbytelomerepositioneffect |