Proton Beam Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma
Purpose: To discuss the role of proton beam therapy (PBT) in the treatment of patients with oropharyngeal squamous cell carcinoma (OPSCC). Materials and Methods: A review of the pertinent literature. Results: Proton beam therapy likely results in reduced acute and late toxicity as compared with inte...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Particle Therapy Co-operative Group
2023-04-01
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| Series: | International Journal of Particle Therapy |
| Subjects: | |
| Online Access: | https://theijpt.org/doi/pdf/10.14338/IJPT-22-00030.1 |
| _version_ | 1797831445424635904 |
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| author | William M. Mendenhall, MD Jonathan J. Beitler, MD, MBA Nabil F. Saba, MD, FACP Ashok R. Shaha, MD, FACS Sandra Nuyts, MD, PhD Primož Strojan, MD Heleen Bollen, MD Oded Cohen, MD Robert Smee, MD Sweet Ping Ng, MD Avraham Eisbruch, MD Wai Tong Ng, MD Jessica M. Kirwan, MA Alfio Ferlito, MD, DLO, DPath, FRCSEd ad hominem, FRCS (Eng, Glasg, Ir) ad eundem, FDSRCS ad eundem, FACS, FHKCORL, FRCPath, FASCP, IFCAP |
| author_facet | William M. Mendenhall, MD Jonathan J. Beitler, MD, MBA Nabil F. Saba, MD, FACP Ashok R. Shaha, MD, FACS Sandra Nuyts, MD, PhD Primož Strojan, MD Heleen Bollen, MD Oded Cohen, MD Robert Smee, MD Sweet Ping Ng, MD Avraham Eisbruch, MD Wai Tong Ng, MD Jessica M. Kirwan, MA Alfio Ferlito, MD, DLO, DPath, FRCSEd ad hominem, FRCS (Eng, Glasg, Ir) ad eundem, FDSRCS ad eundem, FACS, FHKCORL, FRCPath, FASCP, IFCAP |
| author_sort | William M. Mendenhall, MD |
| collection | DOAJ |
| description | Purpose: To discuss the role of proton beam therapy (PBT) in the treatment of patients with oropharyngeal squamous cell carcinoma (OPSCC).
Materials and Methods: A review of the pertinent literature.
Results: Proton beam therapy likely results in reduced acute and late toxicity as compared with intensity-modulated radiation therapy (IMRT). The extent of the reduced toxicity, which may be modest, depends on the endpoint and technical factors such as pencil beam versus passive scattered PBT and adaptive replanning. The disease control rates after PBT are likely similar to those after IMRT.
Conclusion: Proton beam therapy is an attractive option to treat patients with OPSCC. Whether it becomes widely available depends on access. |
| first_indexed | 2024-04-09T13:52:59Z |
| format | Article |
| id | doaj.art-f38473e8146f48049b2d5d531735ec05 |
| institution | Directory Open Access Journal |
| issn | 2331-5180 |
| language | English |
| last_indexed | 2024-04-09T13:52:59Z |
| publishDate | 2023-04-01 |
| publisher | Particle Therapy Co-operative Group |
| record_format | Article |
| series | International Journal of Particle Therapy |
| spelling | doaj.art-f38473e8146f48049b2d5d531735ec052023-05-08T13:32:18ZengParticle Therapy Co-operative GroupInternational Journal of Particle Therapy2331-51802023-04-019424325210.14338/IJPT-22-00030.1i2331-5180-9-4-243Proton Beam Radiation Therapy for Oropharyngeal Squamous Cell CarcinomaWilliam M. Mendenhall, MD0Jonathan J. Beitler, MD, MBA1Nabil F. Saba, MD, FACP2Ashok R. Shaha, MD, FACS3Sandra Nuyts, MD, PhD4Primož Strojan, MD5Heleen Bollen, MD6Oded Cohen, MD7Robert Smee, MD8Sweet Ping Ng, MD9Avraham Eisbruch, MD10Wai Tong Ng, MD11Jessica M. Kirwan, MA12Alfio Ferlito, MD, DLO, DPath, FRCSEd ad hominem, FRCS (Eng, Glasg, Ir) ad eundem, FDSRCS ad eundem, FACS, FHKCORL, FRCPath, FASCP, IFCAP131 Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA2 Harold Alfonds Center for Cancer Care, Maine General Hospital, Augusta, ME, USA3 Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA4 Department of Head and Neck Surgery and Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA5 Department of Radiation Oncology, Leuven Cancer Institute, University Hospitals Leuven, KU Leuven -University of Leuven, Leuven, Belgium7 Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia5 Department of Radiation Oncology, Leuven Cancer Institute, University Hospitals Leuven, KU Leuven -University of Leuven, Leuven, Belgium8 Department of Otolaryngology - Head and Neck Surgery and Oncology, Soroka Medical Center, Tel Aviv, Affiliated with Ben Gurion University of the Negev, Beer Sheva, Israel9 Department of Radiation Oncology, The Prince of Wales Cancer Centre, Sydney, NSW, Australia10 Department of Radiation Oncology, Olivia Newton-John Cancer Centre, Austin Health, Melbourne, Australia11 Department of Radiation Oncology, University of Michigan Medicine, Ann Arbor, Michigan, USA12 Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China1 Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA13 Coordinator of the International Head and Neck Scientific Group, Padua, ItalyPurpose: To discuss the role of proton beam therapy (PBT) in the treatment of patients with oropharyngeal squamous cell carcinoma (OPSCC). Materials and Methods: A review of the pertinent literature. Results: Proton beam therapy likely results in reduced acute and late toxicity as compared with intensity-modulated radiation therapy (IMRT). The extent of the reduced toxicity, which may be modest, depends on the endpoint and technical factors such as pencil beam versus passive scattered PBT and adaptive replanning. The disease control rates after PBT are likely similar to those after IMRT. Conclusion: Proton beam therapy is an attractive option to treat patients with OPSCC. Whether it becomes widely available depends on access.https://theijpt.org/doi/pdf/10.14338/IJPT-22-00030.1particle therapyhead and neck canceroropharynxcancer outcomes |
| spellingShingle | William M. Mendenhall, MD Jonathan J. Beitler, MD, MBA Nabil F. Saba, MD, FACP Ashok R. Shaha, MD, FACS Sandra Nuyts, MD, PhD Primož Strojan, MD Heleen Bollen, MD Oded Cohen, MD Robert Smee, MD Sweet Ping Ng, MD Avraham Eisbruch, MD Wai Tong Ng, MD Jessica M. Kirwan, MA Alfio Ferlito, MD, DLO, DPath, FRCSEd ad hominem, FRCS (Eng, Glasg, Ir) ad eundem, FDSRCS ad eundem, FACS, FHKCORL, FRCPath, FASCP, IFCAP Proton Beam Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma International Journal of Particle Therapy particle therapy head and neck cancer oropharynx cancer outcomes |
| title | Proton Beam Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma |
| title_full | Proton Beam Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma |
| title_fullStr | Proton Beam Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma |
| title_full_unstemmed | Proton Beam Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma |
| title_short | Proton Beam Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma |
| title_sort | proton beam radiation therapy for oropharyngeal squamous cell carcinoma |
| topic | particle therapy head and neck cancer oropharynx cancer outcomes |
| url | https://theijpt.org/doi/pdf/10.14338/IJPT-22-00030.1 |
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