Botulinum Toxin Injection for Medically Refractory Neurogenic Bladder in Children: A Systematic Review
The objective was to evaluate the use of botulinum toxin A (BTX-A) injection in children with medically refractory neurogenic bladder. A systematic review of the literature was conducted using three databases (Medline via PubMed, Cochrane, and EMBASE). Articles evaluating BTX-A in children with neur...
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MDPI AG
2021-06-01
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| Online Access: | https://www.mdpi.com/2072-6651/13/7/447 |
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| author | Shu-Yu Wu Shang-Jen Chang Stephen Shei-Dei Yang Chun-Kai Hsu |
| author_facet | Shu-Yu Wu Shang-Jen Chang Stephen Shei-Dei Yang Chun-Kai Hsu |
| author_sort | Shu-Yu Wu |
| collection | DOAJ |
| description | The objective was to evaluate the use of botulinum toxin A (BTX-A) injection in children with medically refractory neurogenic bladder. A systematic review of the literature was conducted using three databases (Medline via PubMed, Cochrane, and EMBASE). Articles evaluating BTX-A in children with neurogenic bladder were collected. The clinical and urodynamic parameters were reviewed for the safety and efficacy evaluation. Sixteen studies were selected into this study and a total of 455 children with medical refractory neurogenic bladder were evaluated. All of the patients had received traditional conservative medications such as antimuscarinics and intermittent catheterization as previous treatment. The duration of treatments ranged from 2 months to 5.7 years. Improvements in incontinence and vesicoureteral reflux were the most common clinical outcomes. The detrusor pressure, bladder capacity and bladder compliance improvement were the most common urodynamic parameters which had been reported. However, patient satisfaction with the procedure remained controversial. There was only a minimal risk of minor adverse effects. In all of the studies, BTX-A injection was well tolerated. In conclusion, BTX-A injection appears to be a safe and effective treatment in the management of medically unresponsive neurogenic bladder in children. There is currently no evidence that the use of BTX-A injection could be used as a first-line therapy for neurogenic bladder in children. |
| first_indexed | 2024-03-09T04:46:28Z |
| format | Article |
| id | doaj.art-f384d424e8bf42efbe21bf6873ae106e |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-09T04:46:28Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-f384d424e8bf42efbe21bf6873ae106e2023-12-03T13:15:13ZengMDPI AGToxins2072-66512021-06-0113744710.3390/toxins13070447Botulinum Toxin Injection for Medically Refractory Neurogenic Bladder in Children: A Systematic ReviewShu-Yu Wu0Shang-Jen Chang1Stephen Shei-Dei Yang2Chun-Kai Hsu3Division of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, TaiwanDivision of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, TaiwanDivision of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, TaiwanDivision of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, TaiwanThe objective was to evaluate the use of botulinum toxin A (BTX-A) injection in children with medically refractory neurogenic bladder. A systematic review of the literature was conducted using three databases (Medline via PubMed, Cochrane, and EMBASE). Articles evaluating BTX-A in children with neurogenic bladder were collected. The clinical and urodynamic parameters were reviewed for the safety and efficacy evaluation. Sixteen studies were selected into this study and a total of 455 children with medical refractory neurogenic bladder were evaluated. All of the patients had received traditional conservative medications such as antimuscarinics and intermittent catheterization as previous treatment. The duration of treatments ranged from 2 months to 5.7 years. Improvements in incontinence and vesicoureteral reflux were the most common clinical outcomes. The detrusor pressure, bladder capacity and bladder compliance improvement were the most common urodynamic parameters which had been reported. However, patient satisfaction with the procedure remained controversial. There was only a minimal risk of minor adverse effects. In all of the studies, BTX-A injection was well tolerated. In conclusion, BTX-A injection appears to be a safe and effective treatment in the management of medically unresponsive neurogenic bladder in children. There is currently no evidence that the use of BTX-A injection could be used as a first-line therapy for neurogenic bladder in children.https://www.mdpi.com/2072-6651/13/7/447botulinum toxinneurogenic bladderchildren |
| spellingShingle | Shu-Yu Wu Shang-Jen Chang Stephen Shei-Dei Yang Chun-Kai Hsu Botulinum Toxin Injection for Medically Refractory Neurogenic Bladder in Children: A Systematic Review Toxins botulinum toxin neurogenic bladder children |
| title | Botulinum Toxin Injection for Medically Refractory Neurogenic Bladder in Children: A Systematic Review |
| title_full | Botulinum Toxin Injection for Medically Refractory Neurogenic Bladder in Children: A Systematic Review |
| title_fullStr | Botulinum Toxin Injection for Medically Refractory Neurogenic Bladder in Children: A Systematic Review |
| title_full_unstemmed | Botulinum Toxin Injection for Medically Refractory Neurogenic Bladder in Children: A Systematic Review |
| title_short | Botulinum Toxin Injection for Medically Refractory Neurogenic Bladder in Children: A Systematic Review |
| title_sort | botulinum toxin injection for medically refractory neurogenic bladder in children a systematic review |
| topic | botulinum toxin neurogenic bladder children |
| url | https://www.mdpi.com/2072-6651/13/7/447 |
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