A High-Throughput Phenotypic Screen of the ‘Pandemic Response Box’ Identifies a Quinoline Derivative with Significant Anthelmintic Activity

A High-Throughput Phenotypic Screen of the ‘Pandemic Response Box’ Identifies a Quinoline Derivative with Significant Anthelmintic Activity

Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematodes of the order Strongylida, including <i>Haemonchus contortus</i>, are particularly important. The excessive use of anthelmintic compounds to treat infections...

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Bibliographic Details
Main Authors: Harrison T. Shanley, Aya C. Taki, Joseph J. Byrne, Abdul Jabbar, Tim N. C. Wells, Kirandeep Samby, Peter R. Boag, Nghi Nguyen, Brad E. Sleebs, Robin B. Gasser
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceuticals
Subjects:
<i>Haemonchus contortus</i>
parasitic nematode
<i>Caenorhabditis elegans</i>
anthelmintics
small molecules
<i>Pandemic Response Box</i>
Online Access:https://www.mdpi.com/1424-8247/15/2/257

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