The Challenges of OSCC Diagnosis: Salivary Cytokines as Potential Biomarkers
Fast, economic, and noninvasive, molecular analysis of saliva has the potential to become a diagnostic tool of reference for several local and systemic diseases, oral cancer included. The diagnosis of Oral Squamous Cell Carcinoma (OSCC) can be performed using high specificity and sensibility biomark...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/9/2866 |
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| author | Alexandra Roi Ciprian Ioan Roi Meda Lavinia Negruțiu Mircea Riviș Cosmin Sinescu Laura-Cristina Rusu |
| author_facet | Alexandra Roi Ciprian Ioan Roi Meda Lavinia Negruțiu Mircea Riviș Cosmin Sinescu Laura-Cristina Rusu |
| author_sort | Alexandra Roi |
| collection | DOAJ |
| description | Fast, economic, and noninvasive, molecular analysis of saliva has the potential to become a diagnostic tool of reference for several local and systemic diseases, oral cancer included. The diagnosis of Oral Squamous Cell Carcinoma (OSCC) can be performed using high specificity and sensibility biomarkers that can be encountered in the biological fluids. Recent advances in salivary proteomics have underlined the potential use of salivary biomarkers as early diagnosis screening tools for oral neoplasia. In this respect, over 100 salivary molecules have been described and proposed as oral cancer biomarkers, out of which cytokines are among the most promising. Besides being directly involved in inflammation and immune response, the role of salivary cytokines in tumor growth and progression linked them to the incidence of oral malignant lesions. This review summarizes the existing studies based on the use of salivary cytokines as potential oral cancer biomarkers, their involvement in the malignant process based on their type, and ther influence upon prognostic and metastatic rates. |
| first_indexed | 2024-03-10T16:34:26Z |
| format | Article |
| id | doaj.art-f38b38166d7a4fcfb2b4a20715560a5a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T16:34:26Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f38b38166d7a4fcfb2b4a20715560a5a2023-11-20T12:36:56ZengMDPI AGJournal of Clinical Medicine2077-03832020-09-0199286610.3390/jcm9092866The Challenges of OSCC Diagnosis: Salivary Cytokines as Potential BiomarkersAlexandra Roi0Ciprian Ioan Roi1Meda Lavinia Negruțiu2Mircea Riviș3Cosmin Sinescu4Laura-Cristina Rusu5Department of Oral Pathology, “Victor Babeș” University of Medicine and Pharmacy Timisoara, Romania, Eftimie Murgu Sq. no.2, 300041 Timisoara, RomaniaDepartment of Anaesthesiology and Oral Surgery, “Victor Babeș” University of Medicine and Pharmacy Timisoara, Romania, Eftimie Murgu Sq. no.2, 300041 Timisoara, RomaniaDepartment of Propedeutics, “Victor Babeș” University of Medicine and Pharmacy Timisoara, Romania, Eftimie Murgu Sq. no.2, 300041 Timisoara, RomaniaDepartment of Anaesthesiology and Oral Surgery, “Victor Babeș” University of Medicine and Pharmacy Timisoara, Romania, Eftimie Murgu Sq. no.2, 300041 Timisoara, RomaniaDepartment of Propedeutics, “Victor Babeș” University of Medicine and Pharmacy Timisoara, Romania, Eftimie Murgu Sq. no.2, 300041 Timisoara, RomaniaDepartment of Oral Pathology, “Victor Babeș” University of Medicine and Pharmacy Timisoara, Romania, Eftimie Murgu Sq. no.2, 300041 Timisoara, RomaniaFast, economic, and noninvasive, molecular analysis of saliva has the potential to become a diagnostic tool of reference for several local and systemic diseases, oral cancer included. The diagnosis of Oral Squamous Cell Carcinoma (OSCC) can be performed using high specificity and sensibility biomarkers that can be encountered in the biological fluids. Recent advances in salivary proteomics have underlined the potential use of salivary biomarkers as early diagnosis screening tools for oral neoplasia. In this respect, over 100 salivary molecules have been described and proposed as oral cancer biomarkers, out of which cytokines are among the most promising. Besides being directly involved in inflammation and immune response, the role of salivary cytokines in tumor growth and progression linked them to the incidence of oral malignant lesions. This review summarizes the existing studies based on the use of salivary cytokines as potential oral cancer biomarkers, their involvement in the malignant process based on their type, and ther influence upon prognostic and metastatic rates.https://www.mdpi.com/2077-0383/9/9/2866salivacytokinesbiomoleculesbiomarkersoral cancerearly diagnosis |
| spellingShingle | Alexandra Roi Ciprian Ioan Roi Meda Lavinia Negruțiu Mircea Riviș Cosmin Sinescu Laura-Cristina Rusu The Challenges of OSCC Diagnosis: Salivary Cytokines as Potential Biomarkers Journal of Clinical Medicine saliva cytokines biomolecules biomarkers oral cancer early diagnosis |
| title | The Challenges of OSCC Diagnosis: Salivary Cytokines as Potential Biomarkers |
| title_full | The Challenges of OSCC Diagnosis: Salivary Cytokines as Potential Biomarkers |
| title_fullStr | The Challenges of OSCC Diagnosis: Salivary Cytokines as Potential Biomarkers |
| title_full_unstemmed | The Challenges of OSCC Diagnosis: Salivary Cytokines as Potential Biomarkers |
| title_short | The Challenges of OSCC Diagnosis: Salivary Cytokines as Potential Biomarkers |
| title_sort | challenges of oscc diagnosis salivary cytokines as potential biomarkers |
| topic | saliva cytokines biomolecules biomarkers oral cancer early diagnosis |
| url | https://www.mdpi.com/2077-0383/9/9/2866 |
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