Effect of Dioscorea villosa extract and the phytoestrogen diosgenin on ovariectomized mice with zymosan-induced arthritis
Abstract Humans are exposed to natural compounds such as phytoestrogens primarily through diet and supplements. These compounds promote health by alleviating the symptoms and illnesses associated with menopause and arthritis. Diosgenin (DSG) occurs naturally in plants such as Dioscorea villosa (DV)...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2024-02-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502024000100302&lng=en&tlng=en |
| _version_ | 1827340640291127296 |
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| author | Luiz André Santos Silva Jéssica Maria Dantas Araújo Damião Rabelo de Almeida Luiz Felipe Lobo Mascarenhas Fratel de Araújo Eloísa Portugal Barros Silva Soares de Souza Saulo Santos Matos Cláudio Moreira de Lima Adriano Antunes de Souza Araújo Enilton Aparecido Camargo Renata Grespan |
| author_facet | Luiz André Santos Silva Jéssica Maria Dantas Araújo Damião Rabelo de Almeida Luiz Felipe Lobo Mascarenhas Fratel de Araújo Eloísa Portugal Barros Silva Soares de Souza Saulo Santos Matos Cláudio Moreira de Lima Adriano Antunes de Souza Araújo Enilton Aparecido Camargo Renata Grespan |
| author_sort | Luiz André Santos Silva |
| collection | DOAJ |
| description | Abstract Humans are exposed to natural compounds such as phytoestrogens primarily through diet and supplements. These compounds promote health by alleviating the symptoms and illnesses associated with menopause and arthritis. Diosgenin (DSG) occurs naturally in plants such as Dioscorea villosa (DV) and binds to estrogen receptors, so it may have similar effects to this hormone, including against arthritis. Thus, we investigated the effect of chronic treatment with dry extract of DV and its phytoestrogen DSG on ovariectomized mice with arthritis. We found that dry extract of Dioscorea villosa (DV) contains the phytoestrogen diosgenin (DSG) in its composition. Furthermore, arthritic mice treated with DV and DSG showed reduced neutrophil accumulation in the articular cartilage. Also, the dry extract of DV administered orally (v.o) did not alter the leukocyte count in the joints or promote changes in the reproductive tract. However, DSG altered these parameters, with possible beneficial effects by reducing symptoms related to reproductive aging. Thus, oral treatment with dry extract of DV and subcutaneous (s.c) treatment with DSG showed promise by acting against inflammation caused by arthritis and reducing symptoms in the reproductive tract due to menopause. |
| first_indexed | 2024-03-07T21:23:26Z |
| format | Article |
| id | doaj.art-f38b561754964c58a334118cd96ebd1c |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-03-07T21:23:26Z |
| publishDate | 2024-02-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-f38b561754964c58a334118cd96ebd1c2024-02-27T07:44:25ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902024-02-016010.1590/s2175-97902024e23203Effect of Dioscorea villosa extract and the phytoestrogen diosgenin on ovariectomized mice with zymosan-induced arthritisLuiz André Santos SilvaJéssica Maria Dantas AraújoDamião Rabelo de AlmeidaLuiz Felipe Lobo Mascarenhas Fratel de AraújoEloísa Portugal Barros Silva Soares de SouzaSaulo Santos MatosCláudio Moreira de LimaAdriano Antunes de Souza AraújoEnilton Aparecido CamargoRenata Grespanhttps://orcid.org/0000-0003-3644-7632Abstract Humans are exposed to natural compounds such as phytoestrogens primarily through diet and supplements. These compounds promote health by alleviating the symptoms and illnesses associated with menopause and arthritis. Diosgenin (DSG) occurs naturally in plants such as Dioscorea villosa (DV) and binds to estrogen receptors, so it may have similar effects to this hormone, including against arthritis. Thus, we investigated the effect of chronic treatment with dry extract of DV and its phytoestrogen DSG on ovariectomized mice with arthritis. We found that dry extract of Dioscorea villosa (DV) contains the phytoestrogen diosgenin (DSG) in its composition. Furthermore, arthritic mice treated with DV and DSG showed reduced neutrophil accumulation in the articular cartilage. Also, the dry extract of DV administered orally (v.o) did not alter the leukocyte count in the joints or promote changes in the reproductive tract. However, DSG altered these parameters, with possible beneficial effects by reducing symptoms related to reproductive aging. Thus, oral treatment with dry extract of DV and subcutaneous (s.c) treatment with DSG showed promise by acting against inflammation caused by arthritis and reducing symptoms in the reproductive tract due to menopause.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502024000100302&lng=en&tlng=enEstrogenMenopauseNatural productRheumatoid arthritisOsteoarthritis |
| spellingShingle | Luiz André Santos Silva Jéssica Maria Dantas Araújo Damião Rabelo de Almeida Luiz Felipe Lobo Mascarenhas Fratel de Araújo Eloísa Portugal Barros Silva Soares de Souza Saulo Santos Matos Cláudio Moreira de Lima Adriano Antunes de Souza Araújo Enilton Aparecido Camargo Renata Grespan Effect of Dioscorea villosa extract and the phytoestrogen diosgenin on ovariectomized mice with zymosan-induced arthritis Brazilian Journal of Pharmaceutical Sciences Estrogen Menopause Natural product Rheumatoid arthritis Osteoarthritis |
| title | Effect of Dioscorea villosa extract and the phytoestrogen diosgenin on ovariectomized mice with zymosan-induced arthritis |
| title_full | Effect of Dioscorea villosa extract and the phytoestrogen diosgenin on ovariectomized mice with zymosan-induced arthritis |
| title_fullStr | Effect of Dioscorea villosa extract and the phytoestrogen diosgenin on ovariectomized mice with zymosan-induced arthritis |
| title_full_unstemmed | Effect of Dioscorea villosa extract and the phytoestrogen diosgenin on ovariectomized mice with zymosan-induced arthritis |
| title_short | Effect of Dioscorea villosa extract and the phytoestrogen diosgenin on ovariectomized mice with zymosan-induced arthritis |
| title_sort | effect of dioscorea villosa extract and the phytoestrogen diosgenin on ovariectomized mice with zymosan induced arthritis |
| topic | Estrogen Menopause Natural product Rheumatoid arthritis Osteoarthritis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502024000100302&lng=en&tlng=en |
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