Is folic acid supplementation to food benefit or risk for human health?
The need for sufficient quantities of folic acid for normal embryogenesis and fetal development is well known. Women of childbearing age must be sure to have an adequate intake of folic acid periconceptionally prior to and during pregnancy. Folate plays an essential role in the biosynthesis of RNA a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2013-12-01
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| Series: | Pteridines |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pterid-2013-0024 |
| _version_ | 1819079386049019904 |
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| author | Bjelakovic Gordana Stojanovic Ivana Jevtovic-Stoimenov Tatjana Bjelakovic Ljiljana Kamenov Borisav Pavlovic Dusica Kocic Gordana Sokolovic Dusan Basic Jelena Bjelakovic Goran B. |
| author_facet | Bjelakovic Gordana Stojanovic Ivana Jevtovic-Stoimenov Tatjana Bjelakovic Ljiljana Kamenov Borisav Pavlovic Dusica Kocic Gordana Sokolovic Dusan Basic Jelena Bjelakovic Goran B. |
| author_sort | Bjelakovic Gordana |
| collection | DOAJ |
| description | The need for sufficient quantities of folic acid for normal embryogenesis and fetal development is well known. Women of childbearing age must be sure to have an adequate intake of folic acid periconceptionally prior to and during pregnancy. Folate plays an essential role in the biosynthesis of RNA and DNA, phospholipid and neurostransmitters synthesis, using S-adenosylmethionine (SAM) as the primary methyl group donor. In some countries, the knowledge that folic acid is preventable for the reduction of the risk for neural tube defects (NTD) and in lowering the high amount of homocysteine (Hcy) led to the recommendation that all women capable of becoming pregnant should consume 400 µg of folic acid daily. Later, in 1998, folic acid fortification of all enriched cereal grain product flour was implemented in some countries. In addition to careful monitoring of adverse effects, the studies are warranted in order to determine the potentially positive and deleterious effects of folic acid fortification and supplementation on the human health or human diseases. To further understand the metabolic action of folates we asked ourselves the question: Is the intake of a sufficient amount of this vitamin a benefit or risk for human health? |
| first_indexed | 2024-12-21T19:28:09Z |
| format | Article |
| id | doaj.art-f38d4e318d6341e3a576251a3c6ee412 |
| institution | Directory Open Access Journal |
| issn | 0933-4807 2195-4720 |
| language | English |
| last_indexed | 2024-12-21T19:28:09Z |
| publishDate | 2013-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pteridines |
| spelling | doaj.art-f38d4e318d6341e3a576251a3c6ee4122022-12-21T18:52:46ZengDe GruyterPteridines0933-48072195-47202013-12-01243-416518110.1515/pterid-2013-0024Is folic acid supplementation to food benefit or risk for human health?Bjelakovic Gordana0Stojanovic Ivana1Jevtovic-Stoimenov Tatjana2Bjelakovic Ljiljana3Kamenov Borisav4Pavlovic Dusica5Kocic Gordana6Sokolovic Dusan7Basic Jelena8Bjelakovic Goran B.9Institute of Biochemistry, Faculty of Medicine, University of Nis, Nis, SerbiaInstitute of Biochemistry, Faculty of Medicine, University of Nis, Nis, SerbiaInstitute of Biochemistry, Faculty of Medicine, University of Nis, Nis, SerbiaDepartment of Medical Science, Institute of Hygiene, Faculty of Sport and Physical Education, University of Nis, Nis, SerbiaClinic for Pediatrics, Faculty of Medicine, University of Nis, Nis, SerbiaInstitute of Biochemistry, Faculty of Medicine, University of Nis, Nis, SerbiaInstitute of Biochemistry, Faculty of Medicine, University of Nis, Nis, SerbiaInstitute of Biochemistry, Faculty of Medicine, University of Nis, Nis, SerbiaInstitute of Biochemistry, Faculty of Medicine, University of Nis, Nis, SerbiaClinic of Gastroenterohepatology, Clinical Center, Faculty of Medicine, University of Nis, Nis, SerbiaThe need for sufficient quantities of folic acid for normal embryogenesis and fetal development is well known. Women of childbearing age must be sure to have an adequate intake of folic acid periconceptionally prior to and during pregnancy. Folate plays an essential role in the biosynthesis of RNA and DNA, phospholipid and neurostransmitters synthesis, using S-adenosylmethionine (SAM) as the primary methyl group donor. In some countries, the knowledge that folic acid is preventable for the reduction of the risk for neural tube defects (NTD) and in lowering the high amount of homocysteine (Hcy) led to the recommendation that all women capable of becoming pregnant should consume 400 µg of folic acid daily. Later, in 1998, folic acid fortification of all enriched cereal grain product flour was implemented in some countries. In addition to careful monitoring of adverse effects, the studies are warranted in order to determine the potentially positive and deleterious effects of folic acid fortification and supplementation on the human health or human diseases. To further understand the metabolic action of folates we asked ourselves the question: Is the intake of a sufficient amount of this vitamin a benefit or risk for human health?https://doi.org/10.1515/pterid-2013-0024deficiencyfolatesfood fortificationhuman healthpolyamines |
| spellingShingle | Bjelakovic Gordana Stojanovic Ivana Jevtovic-Stoimenov Tatjana Bjelakovic Ljiljana Kamenov Borisav Pavlovic Dusica Kocic Gordana Sokolovic Dusan Basic Jelena Bjelakovic Goran B. Is folic acid supplementation to food benefit or risk for human health? Pteridines deficiency folates food fortification human health polyamines |
| title | Is folic acid supplementation to food benefit or risk for human health? |
| title_full | Is folic acid supplementation to food benefit or risk for human health? |
| title_fullStr | Is folic acid supplementation to food benefit or risk for human health? |
| title_full_unstemmed | Is folic acid supplementation to food benefit or risk for human health? |
| title_short | Is folic acid supplementation to food benefit or risk for human health? |
| title_sort | is folic acid supplementation to food benefit or risk for human health |
| topic | deficiency folates food fortification human health polyamines |
| url | https://doi.org/10.1515/pterid-2013-0024 |
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