Profile of Yeasts Isolated from Urinary Tracts of Catheterized Patients
Purpose: Nosocomial fungal infections are important cause of morbidity and mortality in hospital patients. Urinary catheters have been held responsible to cause a large number of hospital acquired Urinary Tract Infections (UTIs). This study was undertaken to determine the incidence of nosocomial...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4003/14-%206614_181213_6614_CE[Ra]_PF1(PAK)_PFA(AK).pdf |
| Summary: | Purpose: Nosocomial fungal infections are important cause of
morbidity and mortality in hospital patients. Urinary catheters
have been held responsible to cause a large number of
hospital acquired Urinary Tract Infections (UTIs). This study
was undertaken to determine the incidence of nosocomial
Candiduria associated with in dwelling urinary catheters,
to characterize the species and assess their resistance to
antifungal agents.
Materials and Methods: Urine specimens from 510
catheterized patients were inoculated on Sabauraud Dextrose
Agar; the species identification of Candida isolates was done
by biochemical tests and antifungal susceptibility testing was
done by disc diffusion method.
Results: Candida was isolated in 112 (21.96%) specimens.
Of these, Candida albicans was commonly isolated in 50.89%
followed by C. tropicalis, C. glabrata, C. krusei, C. parapsilosis,
C. guillermondi and C. pseudotropicalis. Fluconazole resistance
was encountered in some isolates. All C. glabrata and C.
krusei were uniformly resistant to fluconazole and 8 of 16 C.
tropicalis were also resistant to it. But only 7 of 57 isolates
of C. albicans were resistant to it. Resistance to Nystatin was
seen in 34 isolates. Similarly, emergence of resistance was also
seen to Ketoconazole and Itraconazole in 24 of 112 isolates.
Amphoterecin B resistance was exhibited by 3 C. albicans, 2
C. tropicalis, 1 C. glabrata and 1 C. krusei strain. C. albicans is
an important nosocomial pathogen causing UTI in catheterized
patients, nevertheless role of other species of Candida as
emergent pathogens and resistance to antifungal drugs needs
to be emphasized. |
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| ISSN: | 2249-782X 0973-709X |