Radiotherapy of Breast Cancer—Professional Guideline 1st Central-Eastern European Professional Consensus Statement on Breast Cancer
The international radiotherapy (RT) expert panel has revised and updated the RT guidelines that were accepted in 2020 at the 4th Hungarian Breast Cancer Consensus Conference, based on new scientific evidence. Radiotherapy after breast-conserving surgery (BCS) is indicated in ductal carcinoma in situ...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Pathology and Oncology Research |
| Subjects: | |
| Online Access: | https://www.por-journal.com/articles/10.3389/pore.2022.1610378/full |
| _version_ | 1827292214232875008 |
|---|---|
| author | Csaba Polgár Csaba Polgár Zsuzsanna Kahán Olivera Ivanov Olivera Ivanov Martin Chorváth Andrea Ligačová András Csejtei Gabriella Gábor László Landherr László Mangel Árpád Mayer János Fodor |
| author_facet | Csaba Polgár Csaba Polgár Zsuzsanna Kahán Olivera Ivanov Olivera Ivanov Martin Chorváth Andrea Ligačová András Csejtei Gabriella Gábor László Landherr László Mangel Árpád Mayer János Fodor |
| author_sort | Csaba Polgár |
| collection | DOAJ |
| description | The international radiotherapy (RT) expert panel has revised and updated the RT guidelines that were accepted in 2020 at the 4th Hungarian Breast Cancer Consensus Conference, based on new scientific evidence. Radiotherapy after breast-conserving surgery (BCS) is indicated in ductal carcinoma in situ (stage 0), as RT decreases the risk of local recurrence (LR) by 50–60%. In early stage (stage I-II) invasive breast cancer RT remains a standard treatment following BCS. However, in elderly (≥70 years) patients with stage I, hormone receptor-positive tumour, hormonal therapy without RT can be considered. Hypofractionated whole breast irradiation (WBI) and for selected cases accelerated partial breast irradiation are validated treatment alternatives to conventional WBI administered for 5 weeks. Following mastectomy, RT significantly decreases the risk of LR and improves overall survival of patients who have 1 to 3 or ≥4 positive axillary lymph nodes. In selected cases of patients with 1 to 2 positive sentinel lymph nodes axillary dissection can be substituted with axillary RT. After neoadjuvant systemic treatment (NST) followed by BCS, WBI is mandatory, while after NST followed by mastectomy, locoregional RT should be given in cases of initial stage III–IV and ypN1 axillary status. |
| first_indexed | 2024-04-24T12:53:47Z |
| format | Article |
| id | doaj.art-f393d99b63da48b89ce29f5e121372b0 |
| institution | Directory Open Access Journal |
| issn | 1532-2807 |
| language | English |
| last_indexed | 2024-04-24T12:53:47Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Pathology and Oncology Research |
| spelling | doaj.art-f393d99b63da48b89ce29f5e121372b02024-04-05T16:51:37ZengFrontiers Media S.A.Pathology and Oncology Research1532-28072022-06-012810.3389/pore.2022.16103781610378Radiotherapy of Breast Cancer—Professional Guideline 1st Central-Eastern European Professional Consensus Statement on Breast CancerCsaba Polgár0Csaba Polgár1Zsuzsanna Kahán2Olivera Ivanov3Olivera Ivanov4Martin Chorváth5Andrea Ligačová6András Csejtei7Gabriella Gábor8László Landherr9László Mangel10Árpád Mayer11János Fodor12Centre of Radiotherapy, National Institute of Oncology, Budapest, HungaryDepartment of Oncology, Semmelweis University, Budapest, HungaryDepartment of Oncotherapy, University of Szeged, Szeged, HungaryFaculty of Medicine, University of Novi Sad, Novi Sad, SerbiaDepartment for Radiation Oncology, Oncology Institute of Vojvodina, Sremska Kamenica, SerbiaDepartment of Radiation Oncology, St. Elisabeth Cancer Institute, Slovak Medical University, Bratislava, SlovakiaDepartment of Radiation Oncology, St. Elisabeth Cancer Institute, Slovak Medical University, Bratislava, SlovakiaDepartment of Oncoradiology, Markusovszky University Teaching Hospital, Szombathely, HungaryOncoradiology Centre, Bács-Kiskun County Hospital, Kecskemét, HungaryMunicipal Oncoradiology Centre, Uzsoki Street Hospital, Budapest, Hungary0Oncotherapy Institute, University of Pécs, Pécs, HungaryMunicipal Oncoradiology Centre, Uzsoki Street Hospital, Budapest, HungaryCentre of Radiotherapy, National Institute of Oncology, Budapest, HungaryThe international radiotherapy (RT) expert panel has revised and updated the RT guidelines that were accepted in 2020 at the 4th Hungarian Breast Cancer Consensus Conference, based on new scientific evidence. Radiotherapy after breast-conserving surgery (BCS) is indicated in ductal carcinoma in situ (stage 0), as RT decreases the risk of local recurrence (LR) by 50–60%. In early stage (stage I-II) invasive breast cancer RT remains a standard treatment following BCS. However, in elderly (≥70 years) patients with stage I, hormone receptor-positive tumour, hormonal therapy without RT can be considered. Hypofractionated whole breast irradiation (WBI) and for selected cases accelerated partial breast irradiation are validated treatment alternatives to conventional WBI administered for 5 weeks. Following mastectomy, RT significantly decreases the risk of LR and improves overall survival of patients who have 1 to 3 or ≥4 positive axillary lymph nodes. In selected cases of patients with 1 to 2 positive sentinel lymph nodes axillary dissection can be substituted with axillary RT. After neoadjuvant systemic treatment (NST) followed by BCS, WBI is mandatory, while after NST followed by mastectomy, locoregional RT should be given in cases of initial stage III–IV and ypN1 axillary status.https://www.por-journal.com/articles/10.3389/pore.2022.1610378/fullbreast cancerradiotherapyguidelinesradiation oncologyconsensus |
| spellingShingle | Csaba Polgár Csaba Polgár Zsuzsanna Kahán Olivera Ivanov Olivera Ivanov Martin Chorváth Andrea Ligačová András Csejtei Gabriella Gábor László Landherr László Mangel Árpád Mayer János Fodor Radiotherapy of Breast Cancer—Professional Guideline 1st Central-Eastern European Professional Consensus Statement on Breast Cancer Pathology and Oncology Research breast cancer radiotherapy guidelines radiation oncology consensus |
| title | Radiotherapy of Breast Cancer—Professional Guideline 1st Central-Eastern European Professional Consensus Statement on Breast Cancer |
| title_full | Radiotherapy of Breast Cancer—Professional Guideline 1st Central-Eastern European Professional Consensus Statement on Breast Cancer |
| title_fullStr | Radiotherapy of Breast Cancer—Professional Guideline 1st Central-Eastern European Professional Consensus Statement on Breast Cancer |
| title_full_unstemmed | Radiotherapy of Breast Cancer—Professional Guideline 1st Central-Eastern European Professional Consensus Statement on Breast Cancer |
| title_short | Radiotherapy of Breast Cancer—Professional Guideline 1st Central-Eastern European Professional Consensus Statement on Breast Cancer |
| title_sort | radiotherapy of breast cancer professional guideline 1st central eastern european professional consensus statement on breast cancer |
| topic | breast cancer radiotherapy guidelines radiation oncology consensus |
| url | https://www.por-journal.com/articles/10.3389/pore.2022.1610378/full |
| work_keys_str_mv | AT csabapolgar radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer AT csabapolgar radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer AT zsuzsannakahan radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer AT oliveraivanov radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer AT oliveraivanov radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer AT martinchorvath radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer AT andrealigacova radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer AT andrascsejtei radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer AT gabriellagabor radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer AT laszlolandherr radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer AT laszlomangel radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer AT arpadmayer radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer AT janosfodor radiotherapyofbreastcancerprofessionalguideline1stcentraleasterneuropeanprofessionalconsensusstatementonbreastcancer |