New Organic Salt from Levofloxacin-Citric Acid: What Is the Impact on the Stability and Antibiotic Potency?
This research dealt with the composition, structure determination, stability, and antibiotic potency of a novel organic salt composed of levofloxacin (LF) and citric acid (CA), named levofloxacin-citrate (LC). After a stoichiometric proportion screening, the antibiotic-antioxidant reaction was condu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/7/2166 |
| _version_ | 1827623034261864448 |
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| author | Ilma Nugrahani Agnesya Namira Laksana Hidehiro Uekusa Hironaga Oyama |
| author_facet | Ilma Nugrahani Agnesya Namira Laksana Hidehiro Uekusa Hironaga Oyama |
| author_sort | Ilma Nugrahani |
| collection | DOAJ |
| description | This research dealt with the composition, structure determination, stability, and antibiotic potency of a novel organic salt composed of levofloxacin (LF) and citric acid (CA), named levofloxacin-citrate (LC). After a stoichiometric proportion screening, the antibiotic-antioxidant reaction was conducted by slow and fast evaporation methods. A series of characterizations using thermal analysis, powder X-ray diffractometry, vibrational spectroscopy, and nuclear magnetic resonance confirmed LC formation. The new organic salt showed a distinct thermogram and diffractogram. Next, Fourier transform infrared indicated the change in <i>N</i>-methylamine and carboxylic stretching, confirmed by <sup>1</sup>H nuclear magnetic resonance spectra to elucidate the 2D structure. Finally, single-crystal diffractometry determined LC as a new salt structure three-dimensionally. The attributive improvements were demonstrated on the stability toward the humidity and lighting of LC compared to LF alone. Moreover, the antibiotic potency of LF against <i>Staphylococcus aureus</i> (Gram-positive) and <i>Escherichia coli</i> (Gram-negative) enhanced ~1.5–2-fold by LC. Hereafter, LC is a potential salt antibiotic-antioxidant combination for dosage formulas development. |
| first_indexed | 2024-03-09T11:37:40Z |
| format | Article |
| id | doaj.art-f3960fbba4a647f7a2f9718b73101cbd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T11:37:40Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f3960fbba4a647f7a2f9718b73101cbd2023-11-30T23:40:29ZengMDPI AGMolecules1420-30492022-03-01277216610.3390/molecules27072166New Organic Salt from Levofloxacin-Citric Acid: What Is the Impact on the Stability and Antibiotic Potency?Ilma Nugrahani0Agnesya Namira Laksana1Hidehiro Uekusa2Hironaga Oyama3School of Pharmacy, Bandung Institute of Technology, Bandung 40132, IndonesiaSchool of Pharmacy, Bandung Institute of Technology, Bandung 40132, IndonesiaDepartment of Chemistry, School of Science, Tokyo Institute of Technology, Tokyo 152-8551, JapanDepartment of Chemistry, School of Science, Tokyo Institute of Technology, Tokyo 152-8551, JapanThis research dealt with the composition, structure determination, stability, and antibiotic potency of a novel organic salt composed of levofloxacin (LF) and citric acid (CA), named levofloxacin-citrate (LC). After a stoichiometric proportion screening, the antibiotic-antioxidant reaction was conducted by slow and fast evaporation methods. A series of characterizations using thermal analysis, powder X-ray diffractometry, vibrational spectroscopy, and nuclear magnetic resonance confirmed LC formation. The new organic salt showed a distinct thermogram and diffractogram. Next, Fourier transform infrared indicated the change in <i>N</i>-methylamine and carboxylic stretching, confirmed by <sup>1</sup>H nuclear magnetic resonance spectra to elucidate the 2D structure. Finally, single-crystal diffractometry determined LC as a new salt structure three-dimensionally. The attributive improvements were demonstrated on the stability toward the humidity and lighting of LC compared to LF alone. Moreover, the antibiotic potency of LF against <i>Staphylococcus aureus</i> (Gram-positive) and <i>Escherichia coli</i> (Gram-negative) enhanced ~1.5–2-fold by LC. Hereafter, LC is a potential salt antibiotic-antioxidant combination for dosage formulas development.https://www.mdpi.com/1420-3049/27/7/2166organic saltlevofloxacincitric acidlevofloxacin-citratestabilityantibiotic potency |
| spellingShingle | Ilma Nugrahani Agnesya Namira Laksana Hidehiro Uekusa Hironaga Oyama New Organic Salt from Levofloxacin-Citric Acid: What Is the Impact on the Stability and Antibiotic Potency? Molecules organic salt levofloxacin citric acid levofloxacin-citrate stability antibiotic potency |
| title | New Organic Salt from Levofloxacin-Citric Acid: What Is the Impact on the Stability and Antibiotic Potency? |
| title_full | New Organic Salt from Levofloxacin-Citric Acid: What Is the Impact on the Stability and Antibiotic Potency? |
| title_fullStr | New Organic Salt from Levofloxacin-Citric Acid: What Is the Impact on the Stability and Antibiotic Potency? |
| title_full_unstemmed | New Organic Salt from Levofloxacin-Citric Acid: What Is the Impact on the Stability and Antibiotic Potency? |
| title_short | New Organic Salt from Levofloxacin-Citric Acid: What Is the Impact on the Stability and Antibiotic Potency? |
| title_sort | new organic salt from levofloxacin citric acid what is the impact on the stability and antibiotic potency |
| topic | organic salt levofloxacin citric acid levofloxacin-citrate stability antibiotic potency |
| url | https://www.mdpi.com/1420-3049/27/7/2166 |
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