Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy

Abstract Autoimmune retinopathy (AIR) is a rare immune-mediated inflammation of the retina. The autoantibodies against retinal proteins and glycolytic enzymes were reported to be involved in the pathogenesis. This retrospective cohort study assessed the antiretinal autoantibody profiles and their as...

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Main Authors: Aulia Rahmi Pawestri, Niracha Arjkongharn, Ragkit Suvannaboon, Aekkachai Tuekprakhon, Vichien Srimuninnimit, Suthipol Udompunthurak, La-ongsri Atchaneeyasakul, Ajchara Koolvisoot, Adisak Trinavarat
Format: Article
Language:English
Published: Nature Portfolio 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94377-0
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author Aulia Rahmi Pawestri
Niracha Arjkongharn
Ragkit Suvannaboon
Aekkachai Tuekprakhon
Vichien Srimuninnimit
Suthipol Udompunthurak
La-ongsri Atchaneeyasakul
Ajchara Koolvisoot
Adisak Trinavarat
author_facet Aulia Rahmi Pawestri
Niracha Arjkongharn
Ragkit Suvannaboon
Aekkachai Tuekprakhon
Vichien Srimuninnimit
Suthipol Udompunthurak
La-ongsri Atchaneeyasakul
Ajchara Koolvisoot
Adisak Trinavarat
author_sort Aulia Rahmi Pawestri
collection DOAJ
description Abstract Autoimmune retinopathy (AIR) is a rare immune-mediated inflammation of the retina. The autoantibodies against retinal proteins and glycolytic enzymes were reported to be involved in the pathogenesis. This retrospective cohort study assessed the antiretinal autoantibody profiles and their association with clinical outcomes of AIR patients in Thailand. We included 44 patients, 75% were females, with the overall median age of onset of 48 (17–74, IQR 40–55.5) years. Common clinical presentations were nyctalopia (65.9%), blurred vision (52.3%), constricted visual field (43.2%), and nonrecordable electroretinography (65.9%). Underlying malignancy and autoimmune diseases were found in 2 and 12 female patients, respectively. We found 41 autoantibodies, with anti-α-enolase (65.9%) showing the highest prevalence, followed by anti-CAII (43.2%), anti-aldolase (40.9%), and anti-GAPDH (36.4%). Anti-aldolase was associated with male gender (P = 0.012, OR 7.11, 95% CI 1.54–32.91). Anti-CAII showed significant association with age of onset (P = 0.025, 95% CI − 17.28 to − 1.24), while anti-α-enolase (P = 0.002, OR 4.37, 95% CI 1.83–10.37) and anti-GAPDH (P = 0.001, OR 1.87, 95% CI 1.32–2.64) were significantly associated with nonrecordable electroretinography. Association between the antibody profiles and clinical outcomes may be used to direct and adjust the treatment plans and provide insights in the pathogenesis of AIR.
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spelling doaj.art-f3966f32f8cd438bbabeca4a7dca4e9f2022-12-21T22:55:47ZengNature PortfolioScientific Reports2045-23222021-07-0111111010.1038/s41598-021-94377-0Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathyAulia Rahmi Pawestri0Niracha Arjkongharn1Ragkit Suvannaboon2Aekkachai Tuekprakhon3Vichien Srimuninnimit4Suthipol Udompunthurak5La-ongsri Atchaneeyasakul6Ajchara Koolvisoot7Adisak Trinavarat8Faculty of Medicine, Universitas BrawijayaDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Medical Oncology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityClinical Epidemiology Division, Siriraj Medical Research Center, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityAbstract Autoimmune retinopathy (AIR) is a rare immune-mediated inflammation of the retina. The autoantibodies against retinal proteins and glycolytic enzymes were reported to be involved in the pathogenesis. This retrospective cohort study assessed the antiretinal autoantibody profiles and their association with clinical outcomes of AIR patients in Thailand. We included 44 patients, 75% were females, with the overall median age of onset of 48 (17–74, IQR 40–55.5) years. Common clinical presentations were nyctalopia (65.9%), blurred vision (52.3%), constricted visual field (43.2%), and nonrecordable electroretinography (65.9%). Underlying malignancy and autoimmune diseases were found in 2 and 12 female patients, respectively. We found 41 autoantibodies, with anti-α-enolase (65.9%) showing the highest prevalence, followed by anti-CAII (43.2%), anti-aldolase (40.9%), and anti-GAPDH (36.4%). Anti-aldolase was associated with male gender (P = 0.012, OR 7.11, 95% CI 1.54–32.91). Anti-CAII showed significant association with age of onset (P = 0.025, 95% CI − 17.28 to − 1.24), while anti-α-enolase (P = 0.002, OR 4.37, 95% CI 1.83–10.37) and anti-GAPDH (P = 0.001, OR 1.87, 95% CI 1.32–2.64) were significantly associated with nonrecordable electroretinography. Association between the antibody profiles and clinical outcomes may be used to direct and adjust the treatment plans and provide insights in the pathogenesis of AIR.https://doi.org/10.1038/s41598-021-94377-0
spellingShingle Aulia Rahmi Pawestri
Niracha Arjkongharn
Ragkit Suvannaboon
Aekkachai Tuekprakhon
Vichien Srimuninnimit
Suthipol Udompunthurak
La-ongsri Atchaneeyasakul
Ajchara Koolvisoot
Adisak Trinavarat
Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy
Scientific Reports
title Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy
title_full Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy
title_fullStr Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy
title_full_unstemmed Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy
title_short Autoantibody profiles and clinical association in Thai patients with autoimmune retinopathy
title_sort autoantibody profiles and clinical association in thai patients with autoimmune retinopathy
url https://doi.org/10.1038/s41598-021-94377-0
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