Association between periodontitis and depression severity – A cross-sectional study of the older population in Hamburg
The aim of the current study is to investigate the association between periodontitis (exposure variable) and depression severity (outcome variable) in an older German population. We evaluated data from 6,209 participants (median age 62 years) of the Hamburg City Health Study (HCHS). The HCHS is a pr...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354623001035 |
| _version_ | 1797422540256182272 |
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| author | Carolin Walther Berit Lieske Katrin Borof Simone Kühn Martin Härter Bernd Löwe Thomas Beikler Guido Heydecke Piotr Kuta Udo Seedorf Kristin Spinler Jürgen Gallinat Ghazal Aarabi |
| author_facet | Carolin Walther Berit Lieske Katrin Borof Simone Kühn Martin Härter Bernd Löwe Thomas Beikler Guido Heydecke Piotr Kuta Udo Seedorf Kristin Spinler Jürgen Gallinat Ghazal Aarabi |
| author_sort | Carolin Walther |
| collection | DOAJ |
| description | The aim of the current study is to investigate the association between periodontitis (exposure variable) and depression severity (outcome variable) in an older German population. We evaluated data from 6,209 participants (median age 62 years) of the Hamburg City Health Study (HCHS). The HCHS is a prospective cohort study and is registered at ClinicalTrial.gov (NCT03934957). Depression severity were assessed with the 9-item Patient Health Questionnaire (PHQ-9). Periodontal examination included probing depth, gingival recession, plaque index, and bleeding on probing. Descriptive analyses were stratified by periodontitis severity. Multiple linear regression models were adjusted for age, sex, diabetes, education, smoking, and antidepressant medication. Linear regression analyses revealed a significant association between log-transformed depression severity and periodontitis when including the interaction term for periodontitis * age, even after adjusting for age, sex, diabetes, education, smoking and antidepressant medication. We identified a significant association between severe periodontitis and elevated depression severity, which interacts with age. Additionally, we performed a linear regression model for biomarker analyses, which revealed significant associations between depression severity and severe periodontitis with log-transformed inflammatory biomarkers interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hsCRP). In order to identify new therapeutic strategies for patients with depression and periodontal disease, future prospective studies are needed to assess the physiological and psychosocial mechanisms behind this relationship and the causal directionality. |
| first_indexed | 2024-03-09T07:33:46Z |
| format | Article |
| id | doaj.art-f3980e9d7c884b4a8d5f4567b2da45d1 |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-03-09T07:33:46Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-f3980e9d7c884b4a8d5f4567b2da45d12023-12-03T05:43:05ZengElsevierBrain, Behavior, & Immunity - Health2666-35462023-12-0134100689Association between periodontitis and depression severity – A cross-sectional study of the older population in HamburgCarolin Walther0Berit Lieske1Katrin Borof2Simone Kühn3Martin Härter4Bernd Löwe5Thomas Beikler6Guido Heydecke7Piotr Kuta8Udo Seedorf9Kristin Spinler10Jürgen Gallinat11Ghazal Aarabi12Department of Periodontics, Preventive and Restorative Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Periodontics, Preventive and Restorative Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Corresponding author. Department of Periodontics, Preventive and Restorative Dentistry Center for Dental and Oral Medicine University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.Department of Periodontics, Preventive and Restorative Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Psychiatry and Psychotherapy, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Medical Psychology, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Periodontics, Preventive and Restorative Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Prosthetic Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, Center for Diagnostics, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Periodontics, Preventive and Restorative Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Periodontics, Preventive and Restorative Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Psychiatry and Psychotherapy, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Periodontics, Preventive and Restorative Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyThe aim of the current study is to investigate the association between periodontitis (exposure variable) and depression severity (outcome variable) in an older German population. We evaluated data from 6,209 participants (median age 62 years) of the Hamburg City Health Study (HCHS). The HCHS is a prospective cohort study and is registered at ClinicalTrial.gov (NCT03934957). Depression severity were assessed with the 9-item Patient Health Questionnaire (PHQ-9). Periodontal examination included probing depth, gingival recession, plaque index, and bleeding on probing. Descriptive analyses were stratified by periodontitis severity. Multiple linear regression models were adjusted for age, sex, diabetes, education, smoking, and antidepressant medication. Linear regression analyses revealed a significant association between log-transformed depression severity and periodontitis when including the interaction term for periodontitis * age, even after adjusting for age, sex, diabetes, education, smoking and antidepressant medication. We identified a significant association between severe periodontitis and elevated depression severity, which interacts with age. Additionally, we performed a linear regression model for biomarker analyses, which revealed significant associations between depression severity and severe periodontitis with log-transformed inflammatory biomarkers interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hsCRP). In order to identify new therapeutic strategies for patients with depression and periodontal disease, future prospective studies are needed to assess the physiological and psychosocial mechanisms behind this relationship and the causal directionality.http://www.sciencedirect.com/science/article/pii/S2666354623001035PeriodontitisOral healthDepressive disordersDepressionInflammationRisk factor |
| spellingShingle | Carolin Walther Berit Lieske Katrin Borof Simone Kühn Martin Härter Bernd Löwe Thomas Beikler Guido Heydecke Piotr Kuta Udo Seedorf Kristin Spinler Jürgen Gallinat Ghazal Aarabi Association between periodontitis and depression severity – A cross-sectional study of the older population in Hamburg Brain, Behavior, & Immunity - Health Periodontitis Oral health Depressive disorders Depression Inflammation Risk factor |
| title | Association between periodontitis and depression severity – A cross-sectional study of the older population in Hamburg |
| title_full | Association between periodontitis and depression severity – A cross-sectional study of the older population in Hamburg |
| title_fullStr | Association between periodontitis and depression severity – A cross-sectional study of the older population in Hamburg |
| title_full_unstemmed | Association between periodontitis and depression severity – A cross-sectional study of the older population in Hamburg |
| title_short | Association between periodontitis and depression severity – A cross-sectional study of the older population in Hamburg |
| title_sort | association between periodontitis and depression severity a cross sectional study of the older population in hamburg |
| topic | Periodontitis Oral health Depressive disorders Depression Inflammation Risk factor |
| url | http://www.sciencedirect.com/science/article/pii/S2666354623001035 |
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