Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515
Abstract Three new lactones, xylanilyticolides A–C (1–3), were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515. Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis. Compound 1 exhibited potent cytotoxicities ag...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2018-02-01
|
| Series: | Natural Products and Bioprospecting |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13659-018-0154-1 |
| _version_ | 1818543857165402112 |
|---|---|
| author | Zhen-Xiong Wang Shen Qin Li-Hua Xu He-Ping Chen Huan Sun Rong Huang Zheng-Hui Li Tao Feng Ji-Kai Liu |
| author_facet | Zhen-Xiong Wang Shen Qin Li-Hua Xu He-Ping Chen Huan Sun Rong Huang Zheng-Hui Li Tao Feng Ji-Kai Liu |
| author_sort | Zhen-Xiong Wang |
| collection | DOAJ |
| description | Abstract Three new lactones, xylanilyticolides A–C (1–3), were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515. Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis. Compound 1 exhibited potent cytotoxicities against five human cancer cell lines HL-60, A-549, SMMC-7721, MCF-7 and SW480 with the IC50 values of 3.9, 15.2, 11.2, 5.9, and 4.7 μM, respectively. Graphical Abstract |
| first_indexed | 2024-12-11T22:40:55Z |
| format | Article |
| id | doaj.art-f398500349144014ace2c7468aa5e391 |
| institution | Directory Open Access Journal |
| issn | 2192-2195 2192-2209 |
| language | English |
| last_indexed | 2024-12-11T22:40:55Z |
| publishDate | 2018-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj.art-f398500349144014ace2c7468aa5e3912022-12-22T00:47:49ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092018-02-0182919510.1007/s13659-018-0154-1Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515Zhen-Xiong Wang0Shen Qin1Li-Hua Xu2He-Ping Chen3Huan Sun4Rong Huang5Zheng-Hui Li6Tao Feng7Ji-Kai Liu8School of Pharmaceutical Sciences, South-Central University for NationalitiesYunnan Institute of Microbiology, Yunnan UniversityYunnan Institute of Microbiology, Yunnan UniversitySchool of Pharmaceutical Sciences, South-Central University for NationalitiesSchool of Pharmaceutical Sciences, South-Central University for NationalitiesSchool of Pharmaceutical Sciences, South-Central University for NationalitiesSchool of Pharmaceutical Sciences, South-Central University for NationalitiesSchool of Pharmaceutical Sciences, South-Central University for NationalitiesSchool of Pharmaceutical Sciences, South-Central University for NationalitiesAbstract Three new lactones, xylanilyticolides A–C (1–3), were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515. Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis. Compound 1 exhibited potent cytotoxicities against five human cancer cell lines HL-60, A-549, SMMC-7721, MCF-7 and SW480 with the IC50 values of 3.9, 15.2, 11.2, 5.9, and 4.7 μM, respectively. Graphical Abstracthttp://link.springer.com/article/10.1007/s13659-018-0154-1ActinomycetePromicromonospora xylanilyticaXylanilyticolidesCytotoxicity |
| spellingShingle | Zhen-Xiong Wang Shen Qin Li-Hua Xu He-Ping Chen Huan Sun Rong Huang Zheng-Hui Li Tao Feng Ji-Kai Liu Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515 Natural Products and Bioprospecting Actinomycete Promicromonospora xylanilytica Xylanilyticolides Cytotoxicity |
| title | Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515 |
| title_full | Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515 |
| title_fullStr | Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515 |
| title_full_unstemmed | Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515 |
| title_short | Xylanilyticolides A–C, Three New Compounds from Cultures of the Actinomycete Promicromonospora xylanilytica YIM 61515 |
| title_sort | xylanilyticolides a c three new compounds from cultures of the actinomycete promicromonospora xylanilytica yim 61515 |
| topic | Actinomycete Promicromonospora xylanilytica Xylanilyticolides Cytotoxicity |
| url | http://link.springer.com/article/10.1007/s13659-018-0154-1 |
| work_keys_str_mv | AT zhenxiongwang xylanilyticolidesacthreenewcompoundsfromculturesoftheactinomycetepromicromonosporaxylanilyticayim61515 AT shenqin xylanilyticolidesacthreenewcompoundsfromculturesoftheactinomycetepromicromonosporaxylanilyticayim61515 AT lihuaxu xylanilyticolidesacthreenewcompoundsfromculturesoftheactinomycetepromicromonosporaxylanilyticayim61515 AT hepingchen xylanilyticolidesacthreenewcompoundsfromculturesoftheactinomycetepromicromonosporaxylanilyticayim61515 AT huansun xylanilyticolidesacthreenewcompoundsfromculturesoftheactinomycetepromicromonosporaxylanilyticayim61515 AT ronghuang xylanilyticolidesacthreenewcompoundsfromculturesoftheactinomycetepromicromonosporaxylanilyticayim61515 AT zhenghuili xylanilyticolidesacthreenewcompoundsfromculturesoftheactinomycetepromicromonosporaxylanilyticayim61515 AT taofeng xylanilyticolidesacthreenewcompoundsfromculturesoftheactinomycetepromicromonosporaxylanilyticayim61515 AT jikailiu xylanilyticolidesacthreenewcompoundsfromculturesoftheactinomycetepromicromonosporaxylanilyticayim61515 |