Contributing Factors for Morbidity and Mortality in Patients with Organophosphate Poisoning on Mechanical Ventilation: A Retrospective Study in a Teaching Hospital
Introduction: One of the most common causes of poisoning in agricultural based developing countries like India is due to Organophosphorus (OP) compound. Its widespread use and easy availability has increased the likelihood of poisoning with these compounds. Aim: To study the morbidity and morta...
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9038/22116_CE(Ra1)_F(Sh)_PF-1(GU-SRI)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1811265715133480960 |
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| author | Gurulingappa Patil Navya Murthy M. Nikhil |
| author_facet | Gurulingappa Patil Navya Murthy M. Nikhil |
| author_sort | Gurulingappa Patil |
| collection | DOAJ |
| description | Introduction: One of the most common causes of poisoning
in agricultural based developing countries like India is due to
Organophosphorus (OP) compound. Its widespread use and
easy availability has increased the likelihood of poisoning with
these compounds.
Aim: To study the morbidity and mortality in patients with acute
OP poisoning requiring mechanical ventilation.
Materials and Methods: This was a retrospective study
constituting patients of all age groups admitted to the Intensive
Care Unit (ICU) with diagnosis of OP poisoning between
January 2015 to December 2015. Of 66 OP poisoning cases
those patients who went against medical advice, 20 were
excluded from the study and thus 46 patients were included.
Diagnosis was performed from the history taken either from the
patient or from the patient’s relatives and presenting symptoms.
Demographic data, month of the year, age of patient, mode
of poisoning, cholinesterase levels, duration of mechanical
ventilation and mortality were recorded. Data are presented as
mean±SD.
Results: A 97.83% (45/46) of cases were suicidal. Out of 46,
9 were intubated and mechanically ventilated. Duration of
mechanical ventilation varied from less than 48 hours to more
than 7 days. Mortality rate was 50%, 0% and 100% in those
who required mechanical ventilation for more than 7 days, 2
to 7 days and <2days respectively. None of the predictors like
age, severity of poisoning, cholinesterase levels and duration of
ventilation were independent predictors of death and all of them
contributed to the mortality. Overall mortality rate in those who
required mechanical ventilation was 22.22%.
Conclusion: Morbidity and mortality due to OP poisoning
is directly proportional to the age, severity of poisoning and
duration of mechanical ventilation and inversely proportional to
serum cholinesterase level. |
| first_indexed | 2024-04-12T20:28:54Z |
| format | Article |
| id | doaj.art-f39c1484eb864f4d8cf1a4433d9a9bd5 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-12T20:28:54Z |
| publishDate | 2016-12-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-f39c1484eb864f4d8cf1a4433d9a9bd52022-12-22T03:17:48ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-12-011012UC18UC2010.7860/JCDR/2016/22116.9038Contributing Factors for Morbidity and Mortality in Patients with Organophosphate Poisoning on Mechanical Ventilation: A Retrospective Study in a Teaching HospitalGurulingappa Patil0Navya Murthy1M. Nikhil2Associate Professor, Department of Anaesthesiology, Mahadevappa Rampure Medical College/Rajiv Gandhi University of Health Sciences, Kalaburagi, Karnataka, India.Postgraduate Student, Department of Anaesthesiology, Mahadevappa Rampure Medical College/Rajiv Gandhi University of Health Sciences, Kalaburagi, Karnataka, India.Postgraduate Student, Department of Anaesthesiology, Mahadevappa Rampure Medical College/Rajiv Gandhi University of Health Sciences, Kalaburagi, Karnataka, India.Introduction: One of the most common causes of poisoning in agricultural based developing countries like India is due to Organophosphorus (OP) compound. Its widespread use and easy availability has increased the likelihood of poisoning with these compounds. Aim: To study the morbidity and mortality in patients with acute OP poisoning requiring mechanical ventilation. Materials and Methods: This was a retrospective study constituting patients of all age groups admitted to the Intensive Care Unit (ICU) with diagnosis of OP poisoning between January 2015 to December 2015. Of 66 OP poisoning cases those patients who went against medical advice, 20 were excluded from the study and thus 46 patients were included. Diagnosis was performed from the history taken either from the patient or from the patient’s relatives and presenting symptoms. Demographic data, month of the year, age of patient, mode of poisoning, cholinesterase levels, duration of mechanical ventilation and mortality were recorded. Data are presented as mean±SD. Results: A 97.83% (45/46) of cases were suicidal. Out of 46, 9 were intubated and mechanically ventilated. Duration of mechanical ventilation varied from less than 48 hours to more than 7 days. Mortality rate was 50%, 0% and 100% in those who required mechanical ventilation for more than 7 days, 2 to 7 days and <2days respectively. None of the predictors like age, severity of poisoning, cholinesterase levels and duration of ventilation were independent predictors of death and all of them contributed to the mortality. Overall mortality rate in those who required mechanical ventilation was 22.22%. Conclusion: Morbidity and mortality due to OP poisoning is directly proportional to the age, severity of poisoning and duration of mechanical ventilation and inversely proportional to serum cholinesterase level.https://jcdr.net/articles/PDF/9038/22116_CE(Ra1)_F(Sh)_PF-1(GU-SRI)_PFA(AK)_PF2(PAG).pdfatropineintensive care unit managementorganophosphorus poisoningpralidoxime |
| spellingShingle | Gurulingappa Patil Navya Murthy M. Nikhil Contributing Factors for Morbidity and Mortality in Patients with Organophosphate Poisoning on Mechanical Ventilation: A Retrospective Study in a Teaching Hospital Journal of Clinical and Diagnostic Research atropine intensive care unit management organophosphorus poisoning pralidoxime |
| title | Contributing Factors for Morbidity and Mortality in Patients with Organophosphate Poisoning on Mechanical Ventilation: A Retrospective Study in a Teaching Hospital |
| title_full | Contributing Factors for Morbidity and Mortality in Patients with Organophosphate Poisoning on Mechanical Ventilation: A Retrospective Study in a Teaching Hospital |
| title_fullStr | Contributing Factors for Morbidity and Mortality in Patients with Organophosphate Poisoning on Mechanical Ventilation: A Retrospective Study in a Teaching Hospital |
| title_full_unstemmed | Contributing Factors for Morbidity and Mortality in Patients with Organophosphate Poisoning on Mechanical Ventilation: A Retrospective Study in a Teaching Hospital |
| title_short | Contributing Factors for Morbidity and Mortality in Patients with Organophosphate Poisoning on Mechanical Ventilation: A Retrospective Study in a Teaching Hospital |
| title_sort | contributing factors for morbidity and mortality in patients with organophosphate poisoning on mechanical ventilation a retrospective study in a teaching hospital |
| topic | atropine intensive care unit management organophosphorus poisoning pralidoxime |
| url | https://jcdr.net/articles/PDF/9038/22116_CE(Ra1)_F(Sh)_PF-1(GU-SRI)_PFA(AK)_PF2(PAG).pdf |
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