Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study
Background Gout is of unknown reason associated with cardiovascular disease. Ultrasound is sensitive for detecting crystal deposition and plasma calprotectin is a sensitive inflammatory marker. This study explores the associations between crystal deposition, inflammation and carotid artery pathology...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-11-01
|
| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/8/2/e002348.full |
| _version_ | 1827899150930280448 |
|---|---|
| author | Silvia Rollefstad Tore K Kvien Anne Grete Semb Hilde Berner Hammer L Terslev Lars Fridtjof Karoliussen Gro Jensen |
| author_facet | Silvia Rollefstad Tore K Kvien Anne Grete Semb Hilde Berner Hammer L Terslev Lars Fridtjof Karoliussen Gro Jensen |
| author_sort | Silvia Rollefstad |
| collection | DOAJ |
| description | Background Gout is of unknown reason associated with cardiovascular disease. Ultrasound is sensitive for detecting crystal deposition and plasma calprotectin is a sensitive inflammatory marker. This study explores the associations between crystal deposition, inflammation and carotid artery pathology.Method A cross-sectional analysis of baseline assessments from the NOR-Gout study was undertaken. Crystal deposition was assessed by ultrasound (double contour, tophi, aggregates) and dual-energy CT (DECT) and laboratory assessments included plasma calprotectin. The carotid arteries were bilaterally examined for carotid intima–media thickness (cIMT) and presence of plaques. Spearman correlations, Mann-Whitney tests and linear regression analyses were used to explore associations between crystal deposition, inflammatory markers,and carotid pathology.Results 202 patients with intercritical gout (95.5% men, mean (SD) age 56.5 (13.8) years, disease duration 7.9 (7.7) years) were included. Calprotectin was correlated with all scores of crystal deposition by ultrasound (r=0.26–0.32, p<0.001) and DECT (r=0.15, p<0.05). cIMT was correlated with sum score aggregates (r=0.18–0.22, p<0.05). Patients with large tophi had higher levels of calprotectin as well as more frequent carotid plaque (p<0.05).Conclusions Study findings point towards crystal deposition contributing to subclinical inflammation with subsequent vascular implications. However, future longitudinal studies are needed to confirm such causal relationships. |
| first_indexed | 2024-03-12T23:14:00Z |
| format | Article |
| id | doaj.art-f3a1f981ceb2419aa22ce55fcca7e60d |
| institution | Directory Open Access Journal |
| issn | 2056-5933 |
| language | English |
| last_indexed | 2024-03-12T23:14:00Z |
| publishDate | 2022-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj.art-f3a1f981ceb2419aa22ce55fcca7e60d2023-07-17T16:00:06ZengBMJ Publishing GroupRMD Open2056-59332022-11-018210.1136/rmdopen-2022-002348Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout studySilvia Rollefstad0Tore K Kvien1Anne Grete Semb2Hilde Berner Hammer3L Terslev4Lars Fridtjof Karoliussen5Gro Jensen6Peventive Cardio-Rheuma clinic, Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway20 Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, NorwayPeventive Cardio-Rheuma clinic, Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, NorwayCenter for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Sykehus AS, Oslo, NorwayCenter for Rheumatology and Spine Diseases, Rigshospitalet, Kobenhavn, DenmarkDept of Rheumatology, Diakonhjemmet Hospital, Oslo, NorwayClinical chemical laboratory, Diakonhjemmet Hospital, Oslo, NorwayBackground Gout is of unknown reason associated with cardiovascular disease. Ultrasound is sensitive for detecting crystal deposition and plasma calprotectin is a sensitive inflammatory marker. This study explores the associations between crystal deposition, inflammation and carotid artery pathology.Method A cross-sectional analysis of baseline assessments from the NOR-Gout study was undertaken. Crystal deposition was assessed by ultrasound (double contour, tophi, aggregates) and dual-energy CT (DECT) and laboratory assessments included plasma calprotectin. The carotid arteries were bilaterally examined for carotid intima–media thickness (cIMT) and presence of plaques. Spearman correlations, Mann-Whitney tests and linear regression analyses were used to explore associations between crystal deposition, inflammatory markers,and carotid pathology.Results 202 patients with intercritical gout (95.5% men, mean (SD) age 56.5 (13.8) years, disease duration 7.9 (7.7) years) were included. Calprotectin was correlated with all scores of crystal deposition by ultrasound (r=0.26–0.32, p<0.001) and DECT (r=0.15, p<0.05). cIMT was correlated with sum score aggregates (r=0.18–0.22, p<0.05). Patients with large tophi had higher levels of calprotectin as well as more frequent carotid plaque (p<0.05).Conclusions Study findings point towards crystal deposition contributing to subclinical inflammation with subsequent vascular implications. However, future longitudinal studies are needed to confirm such causal relationships.https://rmdopen.bmj.com/content/8/2/e002348.full |
| spellingShingle | Silvia Rollefstad Tore K Kvien Anne Grete Semb Hilde Berner Hammer L Terslev Lars Fridtjof Karoliussen Gro Jensen Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study RMD Open |
| title | Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study |
| title_full | Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study |
| title_fullStr | Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study |
| title_full_unstemmed | Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study |
| title_short | Urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout: results from the NOR-Gout study |
| title_sort | urate crystal deposition is associated with inflammatory markers and carotid artery pathology in patients with intercritical gout results from the nor gout study |
| url | https://rmdopen.bmj.com/content/8/2/e002348.full |
| work_keys_str_mv | AT silviarollefstad uratecrystaldepositionisassociatedwithinflammatorymarkersandcarotidarterypathologyinpatientswithintercriticalgoutresultsfromthenorgoutstudy AT torekkvien uratecrystaldepositionisassociatedwithinflammatorymarkersandcarotidarterypathologyinpatientswithintercriticalgoutresultsfromthenorgoutstudy AT annegretesemb uratecrystaldepositionisassociatedwithinflammatorymarkersandcarotidarterypathologyinpatientswithintercriticalgoutresultsfromthenorgoutstudy AT hildebernerhammer uratecrystaldepositionisassociatedwithinflammatorymarkersandcarotidarterypathologyinpatientswithintercriticalgoutresultsfromthenorgoutstudy AT lterslev uratecrystaldepositionisassociatedwithinflammatorymarkersandcarotidarterypathologyinpatientswithintercriticalgoutresultsfromthenorgoutstudy AT larsfridtjofkaroliussen uratecrystaldepositionisassociatedwithinflammatorymarkersandcarotidarterypathologyinpatientswithintercriticalgoutresultsfromthenorgoutstudy AT grojensen uratecrystaldepositionisassociatedwithinflammatorymarkersandcarotidarterypathologyinpatientswithintercriticalgoutresultsfromthenorgoutstudy |