Ferroptosis and Autoimmune Diseases
Adequate control of autoimmune diseases with an unclear etiology resulting from autoreactivation of the immune system remains a major challenge. One of the factors that trigger autoimmunity is the abnormal induction of cell death and the inadequate clearance of dead cells that leads to the exposure...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.916664/full |
| _version_ | 1811255813822480384 |
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| author | Benjamin Lai Chien-Hsiang Wu Chao-Yi Wu Chao-Yi Wu Shue-Fen Luo Jenn-Haung Lai Jenn-Haung Lai |
| author_facet | Benjamin Lai Chien-Hsiang Wu Chao-Yi Wu Chao-Yi Wu Shue-Fen Luo Jenn-Haung Lai Jenn-Haung Lai |
| author_sort | Benjamin Lai |
| collection | DOAJ |
| description | Adequate control of autoimmune diseases with an unclear etiology resulting from autoreactivation of the immune system remains a major challenge. One of the factors that trigger autoimmunity is the abnormal induction of cell death and the inadequate clearance of dead cells that leads to the exposure or release of intracellular contents that activate the immune system. Different from other cell death subtypes, such as apoptosis, necroptosis, autophagy, and pyroptosis, ferroptosis has a unique association with the cellular iron load (but not the loads of other metals) and preserves its distinguishable morphological, biological, and genetic features. This review addresses how ferroptosis is initiated and how it contributes to the pathogenesis of autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel diseases. The mechanisms responsible for ferroptosis-associated events are discussed. We also cover the perspective of targeting ferroptosis as a potential therapeutic for patients with autoimmune diseases. Collectively, this review provides up-to-date knowledge regarding how ferroptosis occurs and its significance in autoimmune diseases. |
| first_indexed | 2024-04-12T17:30:39Z |
| format | Article |
| id | doaj.art-f3a39d0cfbc14663ab566a9d01eed6f8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T17:30:39Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f3a39d0cfbc14663ab566a9d01eed6f82022-12-22T03:23:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-06-011310.3389/fimmu.2022.916664916664Ferroptosis and Autoimmune DiseasesBenjamin Lai0Chien-Hsiang Wu1Chao-Yi Wu2Chao-Yi Wu3Shue-Fen Luo4Jenn-Haung Lai5Jenn-Haung Lai6Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, TaiwanDivision of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, TaiwanDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, TaiwanDivision of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taoyuan, TaiwanGraduate Institute of Medical Science, National Defense Medical Center, Taipei, TaiwanAdequate control of autoimmune diseases with an unclear etiology resulting from autoreactivation of the immune system remains a major challenge. One of the factors that trigger autoimmunity is the abnormal induction of cell death and the inadequate clearance of dead cells that leads to the exposure or release of intracellular contents that activate the immune system. Different from other cell death subtypes, such as apoptosis, necroptosis, autophagy, and pyroptosis, ferroptosis has a unique association with the cellular iron load (but not the loads of other metals) and preserves its distinguishable morphological, biological, and genetic features. This review addresses how ferroptosis is initiated and how it contributes to the pathogenesis of autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel diseases. The mechanisms responsible for ferroptosis-associated events are discussed. We also cover the perspective of targeting ferroptosis as a potential therapeutic for patients with autoimmune diseases. Collectively, this review provides up-to-date knowledge regarding how ferroptosis occurs and its significance in autoimmune diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2022.916664/fullferroptosissystemic lupus erythematosusrheumatoid arthritisinflammatory bowel diseasesinflammation |
| spellingShingle | Benjamin Lai Chien-Hsiang Wu Chao-Yi Wu Chao-Yi Wu Shue-Fen Luo Jenn-Haung Lai Jenn-Haung Lai Ferroptosis and Autoimmune Diseases Frontiers in Immunology ferroptosis systemic lupus erythematosus rheumatoid arthritis inflammatory bowel diseases inflammation |
| title | Ferroptosis and Autoimmune Diseases |
| title_full | Ferroptosis and Autoimmune Diseases |
| title_fullStr | Ferroptosis and Autoimmune Diseases |
| title_full_unstemmed | Ferroptosis and Autoimmune Diseases |
| title_short | Ferroptosis and Autoimmune Diseases |
| title_sort | ferroptosis and autoimmune diseases |
| topic | ferroptosis systemic lupus erythematosus rheumatoid arthritis inflammatory bowel diseases inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.916664/full |
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