A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia
The meta-analysis was performed to access efficacy of L-carnitine/L-acetyl-carnitine (LC/LAC) and N-acetyl-cysteine (NAC) in men with idiopathic asthenozoospermia. We researched PubMed, EMBASE, and Cochrane Library databases and references to related articles. Finally, seven articles including 621 p...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-04-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/15579883211011371 |
| _version_ | 1818644163353116672 |
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| author | Guangzhu Wei MD Zhongbao Zhou MD Yuanshan Cui MD Yongjin Huang MD Zijin Wan MM Xuanyan Che MM Yumeng Chai MM Yong Zhang MD |
| author_facet | Guangzhu Wei MD Zhongbao Zhou MD Yuanshan Cui MD Yongjin Huang MD Zijin Wan MM Xuanyan Che MM Yumeng Chai MM Yong Zhang MD |
| author_sort | Guangzhu Wei MD |
| collection | DOAJ |
| description | The meta-analysis was performed to access efficacy of L-carnitine/L-acetyl-carnitine (LC/LAC) and N-acetyl-cysteine (NAC) in men with idiopathic asthenozoospermia. We researched PubMed, EMBASE, and Cochrane Library databases and references to related articles. Finally, seven articles including 621 patients were analyzed. The results indicated that LC/LAC and NAC had a considerable improvement in sperm motility ( p = .03 and p < .0001, respectively) and normal morphology ( p = .006, p = .0002, respectively) compared with the placebo group. Besides, NAC had a significantly greater increase in sperm concentration ( p < .00001) and ejaculate volume ( p = .002) compared with the placebo group, and there was no significant difference in LC/LAC. For the analysis of serum hormones, NAC had no obvious differences in improving the serum testosterone, luteinizing hormone, follicle-stimulating hormone, and prolactin compared with non-treatment group. Conclusively, LC/LAC and NAC showed a greater improvement in sperm motility and normal morphology. Moreover, NAC has a positive effect on sperm concentration and ejaculate volume, whereas no obvious effect was observed in serum hormones. |
| first_indexed | 2024-12-17T00:10:29Z |
| format | Article |
| id | doaj.art-f3a57bb5cabc4565b98206b66a8ee884 |
| institution | Directory Open Access Journal |
| issn | 1557-9891 |
| language | English |
| last_indexed | 2024-12-17T00:10:29Z |
| publishDate | 2021-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj.art-f3a57bb5cabc4565b98206b66a8ee8842022-12-21T22:10:51ZengSAGE PublishingAmerican Journal of Men's Health1557-98912021-04-011510.1177/15579883211011371A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic AsthenozoospermiaGuangzhu Wei MD0Zhongbao Zhou MD1Yuanshan Cui MD2Yongjin Huang MD3Zijin Wan MM4Xuanyan Che MM5Yumeng Chai MM6Yong Zhang MD7Department of Urology, Beijing TianTan Hospital, Capital Medical University, Fengtai District, Beijing, ChinaDepartment of Urology, Beijing TianTan Hospital, Capital Medical University, Fengtai District, Beijing, ChinaDepartment of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, ChinaDepartment of Urology, Beijing TianTan Hospital, Capital Medical University, Fengtai District, Beijing, ChinaDepartment of Urology, Beijing TianTan Hospital, Capital Medical University, Fengtai District, Beijing, ChinaDepartment of Urology, Beijing TianTan Hospital, Capital Medical University, Fengtai District, Beijing, ChinaDepartment of Urology, Beijing TianTan Hospital, Capital Medical University, Fengtai District, Beijing, ChinaDepartment of Urology, Beijing TianTan Hospital, Capital Medical University, Fengtai District, Beijing, ChinaThe meta-analysis was performed to access efficacy of L-carnitine/L-acetyl-carnitine (LC/LAC) and N-acetyl-cysteine (NAC) in men with idiopathic asthenozoospermia. We researched PubMed, EMBASE, and Cochrane Library databases and references to related articles. Finally, seven articles including 621 patients were analyzed. The results indicated that LC/LAC and NAC had a considerable improvement in sperm motility ( p = .03 and p < .0001, respectively) and normal morphology ( p = .006, p = .0002, respectively) compared with the placebo group. Besides, NAC had a significantly greater increase in sperm concentration ( p < .00001) and ejaculate volume ( p = .002) compared with the placebo group, and there was no significant difference in LC/LAC. For the analysis of serum hormones, NAC had no obvious differences in improving the serum testosterone, luteinizing hormone, follicle-stimulating hormone, and prolactin compared with non-treatment group. Conclusively, LC/LAC and NAC showed a greater improvement in sperm motility and normal morphology. Moreover, NAC has a positive effect on sperm concentration and ejaculate volume, whereas no obvious effect was observed in serum hormones.https://doi.org/10.1177/15579883211011371 |
| spellingShingle | Guangzhu Wei MD Zhongbao Zhou MD Yuanshan Cui MD Yongjin Huang MD Zijin Wan MM Xuanyan Che MM Yumeng Chai MM Yong Zhang MD A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia American Journal of Men's Health |
| title | A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia |
| title_full | A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia |
| title_fullStr | A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia |
| title_full_unstemmed | A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia |
| title_short | A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia |
| title_sort | meta analysis of the efficacy of l carnitine l acetyl carnitine or n acetyl cysteine in men with idiopathic asthenozoospermia |
| url | https://doi.org/10.1177/15579883211011371 |
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