HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications
Controlling access to genomic information and maintaining its stability are key aspects of cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA and the assembly of protein complexes that regulate mainly transcription but also other activities. Enzymes know...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1116660/full |
| _version_ | 1797945008734601216 |
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| author | Emma Cuttini Camilla Goi Ester Pellarin Riccardo Vida Claudio Brancolini Claudio Brancolini |
| author_facet | Emma Cuttini Camilla Goi Ester Pellarin Riccardo Vida Claudio Brancolini Claudio Brancolini |
| author_sort | Emma Cuttini |
| collection | DOAJ |
| description | Controlling access to genomic information and maintaining its stability are key aspects of cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA and the assembly of protein complexes that regulate mainly transcription but also other activities. Enzymes known as histone deacetylases (HDACs) are involved in the removal of the acetyl-group or in some cases of small hydrophobic moieties from histones but also from the non-histone substrate. The main achievement of HDACs on histones is to repress transcription and promote the formation of more compact chromatin. There are 18 different HDACs encoded in the human genome. Here we will discuss HDAC4, a member of the class IIa family, and its possible contribution to cancer development. |
| first_indexed | 2024-04-10T20:47:31Z |
| format | Article |
| id | doaj.art-f3a59aa123d745bab78f3fac3f6304db |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-10T20:47:31Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-f3a59aa123d745bab78f3fac3f6304db2023-01-24T06:16:28ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-01-011010.3389/fmolb.2023.11166601116660HDAC4 in cancer: A multitasking platform to drive not only epigenetic modificationsEmma Cuttini0Camilla Goi1Ester Pellarin2Riccardo Vida3Claudio Brancolini4Claudio Brancolini5Scuola Superiore Universitaria di Toppo Wassermann, Università degli Studi di Udine, Udine, ItalyScuola Superiore Universitaria di Toppo Wassermann, Università degli Studi di Udine, Udine, ItalyScuola Superiore Universitaria di Toppo Wassermann, Università degli Studi di Udine, Udine, ItalyScuola Superiore Universitaria di Toppo Wassermann, Università degli Studi di Udine, Udine, ItalyScuola Superiore Universitaria di Toppo Wassermann, Università degli Studi di Udine, Udine, ItalyLaboratory of Epigenomics, Department of Medicine, Università degli Studi di Udine, Udine, ItalyControlling access to genomic information and maintaining its stability are key aspects of cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA and the assembly of protein complexes that regulate mainly transcription but also other activities. Enzymes known as histone deacetylases (HDACs) are involved in the removal of the acetyl-group or in some cases of small hydrophobic moieties from histones but also from the non-histone substrate. The main achievement of HDACs on histones is to repress transcription and promote the formation of more compact chromatin. There are 18 different HDACs encoded in the human genome. Here we will discuss HDAC4, a member of the class IIa family, and its possible contribution to cancer development.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1116660/fullHDACsenhancersH3K27acMEF2sarcomassenescence |
| spellingShingle | Emma Cuttini Camilla Goi Ester Pellarin Riccardo Vida Claudio Brancolini Claudio Brancolini HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications Frontiers in Molecular Biosciences HDACs enhancers H3K27ac MEF2 sarcomas senescence |
| title | HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications |
| title_full | HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications |
| title_fullStr | HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications |
| title_full_unstemmed | HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications |
| title_short | HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications |
| title_sort | hdac4 in cancer a multitasking platform to drive not only epigenetic modifications |
| topic | HDACs enhancers H3K27ac MEF2 sarcomas senescence |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1116660/full |
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