TOR Signaling Pathway in Cardiac Aging and Heart Failure
Mechanistic Target of Rapamycin (mTOR) signaling is a key regulator of cellular metabolism, integrating nutrient sensing with cell growth. Over the past two decades, studies on the mTOR pathway have revealed that mTOR complex 1 controls life span, health span, and aging by modulating key cellular pr...
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Format: | Article |
Language: | English |
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MDPI AG
2021-01-01
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Series: | Biomolecules |
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Online Access: | https://www.mdpi.com/2218-273X/11/2/168 |
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author | Nastaran Daneshgar Peter S. Rabinovitch Dao-Fu Dai |
author_facet | Nastaran Daneshgar Peter S. Rabinovitch Dao-Fu Dai |
author_sort | Nastaran Daneshgar |
collection | DOAJ |
description | Mechanistic Target of Rapamycin (mTOR) signaling is a key regulator of cellular metabolism, integrating nutrient sensing with cell growth. Over the past two decades, studies on the mTOR pathway have revealed that mTOR complex 1 controls life span, health span, and aging by modulating key cellular processes such as protein synthesis, autophagy, and mitochondrial function, mainly through its downstream substrates. Thus, the mTOR pathway regulates both physiological and pathological processes in the heart from embryonic cardiovascular development to maintenance of cardiac homeostasis in postnatal life. In this regard, the dysregulation of mTOR signaling has been linked to many age-related pathologies, including heart failure and age-related cardiac dysfunction. In this review, we highlight recent advances of the impact of mTOR complex 1 pathway and its regulators on aging and, more specifically, cardiac aging and heart failure. |
first_indexed | 2024-03-09T03:32:00Z |
format | Article |
id | doaj.art-f3a64f891bb944719af0257f2e7097dc |
institution | Directory Open Access Journal |
issn | 2218-273X |
language | English |
last_indexed | 2024-03-09T03:32:00Z |
publishDate | 2021-01-01 |
publisher | MDPI AG |
record_format | Article |
series | Biomolecules |
spelling | doaj.art-f3a64f891bb944719af0257f2e7097dc2023-12-03T14:55:02ZengMDPI AGBiomolecules2218-273X2021-01-0111216810.3390/biom11020168TOR Signaling Pathway in Cardiac Aging and Heart FailureNastaran Daneshgar0Peter S. Rabinovitch1Dao-Fu Dai2Department of Pathology, University of Iowa, Iowa City, IA 52242, USADepartment of Pathology, University of Washington, Seattle, WA 98195, USADepartment of Pathology, University of Iowa, Iowa City, IA 52242, USAMechanistic Target of Rapamycin (mTOR) signaling is a key regulator of cellular metabolism, integrating nutrient sensing with cell growth. Over the past two decades, studies on the mTOR pathway have revealed that mTOR complex 1 controls life span, health span, and aging by modulating key cellular processes such as protein synthesis, autophagy, and mitochondrial function, mainly through its downstream substrates. Thus, the mTOR pathway regulates both physiological and pathological processes in the heart from embryonic cardiovascular development to maintenance of cardiac homeostasis in postnatal life. In this regard, the dysregulation of mTOR signaling has been linked to many age-related pathologies, including heart failure and age-related cardiac dysfunction. In this review, we highlight recent advances of the impact of mTOR complex 1 pathway and its regulators on aging and, more specifically, cardiac aging and heart failure.https://www.mdpi.com/2218-273X/11/2/168mTORagingcardiac agingheart failurerapamycincaloric restriction |
spellingShingle | Nastaran Daneshgar Peter S. Rabinovitch Dao-Fu Dai TOR Signaling Pathway in Cardiac Aging and Heart Failure Biomolecules mTOR aging cardiac aging heart failure rapamycin caloric restriction |
title | TOR Signaling Pathway in Cardiac Aging and Heart Failure |
title_full | TOR Signaling Pathway in Cardiac Aging and Heart Failure |
title_fullStr | TOR Signaling Pathway in Cardiac Aging and Heart Failure |
title_full_unstemmed | TOR Signaling Pathway in Cardiac Aging and Heart Failure |
title_short | TOR Signaling Pathway in Cardiac Aging and Heart Failure |
title_sort | tor signaling pathway in cardiac aging and heart failure |
topic | mTOR aging cardiac aging heart failure rapamycin caloric restriction |
url | https://www.mdpi.com/2218-273X/11/2/168 |
work_keys_str_mv | AT nastarandaneshgar torsignalingpathwayincardiacagingandheartfailure AT petersrabinovitch torsignalingpathwayincardiacagingandheartfailure AT daofudai torsignalingpathwayincardiacagingandheartfailure |