Edaravone protects against oxygen-glucose-serum deprivation/restoration-induced apoptosis in spinal cord astrocytes by inhibiting integrated stress response

Edaravone protects against oxygen-glucose-serum deprivation/restoration-induced apoptosis in spinal cord astrocytes by inhibiting integrated stress response

We previously found that oxygen-glucose-serum deprivation/restoration (OGSD/R) induces apoptosis of spinal cord astrocytes, possibly via caspase-12 and the integrated stress response, which involves protein kinase R-like endoplasmic reticulum kinase (PERK), eukaryotic initiation factor 2-alpha (eIF2...

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Bibliographic Details
Main Authors: Bin Dai, Ting Yan, Yi-xing Shen, You-jia Xu, Hai-bin Shen, Dong Chen, Jin-rong Wang, Shuang-hua He, Qi-rong Dong, Ai-liang Zhang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; edaravone; apoptosis; astrocytes; integrated stress response; reactive oxygen species; PERK; eIF2α; activating transcription factor 4; CCAAT/enhancer binding protein homologous protein; caspase-3
caspase-12; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=2;spage=283;epage=289;aulast=Dai

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