De novo design and synthesis of ultra-short peptidomimetic antibiotics having dual antimicrobial and anti-inflammatory activities.

De novo design and synthesis of ultra-short peptidomimetic antibiotics having dual antimicrobial and anti-inflammatory activities.

BACKGROUND: Much attention has been focused on the design and synthesis of potent, cationic antimicrobial peptides (AMPs) that possess both antimicrobial and anti-inflammatory activities. However, their development into therapeutic agents has been limited mainly due to their large size (12 to 50 res...

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Main Authors: Ravichandran N Murugan, Binu Jacob, Mija Ahn, Eunha Hwang, Hoik Sohn, Hyo-Nam Park, Eunjung Lee, Ji-Hyung Seo, Chaejoon Cheong, Ky-Youb Nam, Jae-Kyung Hyun, Ki-Woong Jeong, Yangmee Kim, Song Yub Shin, Jeong Kyu Bang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3841161?pdf=render

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