Role of N6-methyladenosine methylation in glioma: recent insights and future directions
Abstract Glioma is the most pervasive intracranial tumor in the central nervous system (CNS), with glioblastoma (GBM) being the most malignant type having a highly heterogeneous cancer cell population. There is a significantly high mortality rate in GBM patients. Molecular biomarkers related to GBM...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-12-01
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| Series: | Cellular & Molecular Biology Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11658-023-00514-0 |
| _version_ | 1797388239485534208 |
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| author | Chunlin Li Bowen Li Hui Wang Linglong Qu Hui Liu Chao Weng Jinming Han Yuan Li |
| author_facet | Chunlin Li Bowen Li Hui Wang Linglong Qu Hui Liu Chao Weng Jinming Han Yuan Li |
| author_sort | Chunlin Li |
| collection | DOAJ |
| description | Abstract Glioma is the most pervasive intracranial tumor in the central nervous system (CNS), with glioblastoma (GBM) being the most malignant type having a highly heterogeneous cancer cell population. There is a significantly high mortality rate in GBM patients. Molecular biomarkers related to GBM malignancy may have prognostic values in predicting survival outcomes and therapeutic responses, especially in patients with high-grade gliomas. In particular, N6-methyladenine (m6A) mRNA modification is the most abundant form of post-transcriptional RNA modification in mammals and is involved in regulating mRNA translation and degradation. Cumulative findings indicate that m6A methylation plays a crucial part in neurogenesis and glioma pathogenesis. In this review, we summarize recent advances regarding the functional significance of m6A modification and its regulatory factors in glioma occurrence and progression. Significant advancement of m6A methylation-associated regulators as potential therapeutic targets is also discussed. |
| first_indexed | 2024-03-08T22:36:56Z |
| format | Article |
| id | doaj.art-f3a8e2e65bde47ad87a020da9b0bba26 |
| institution | Directory Open Access Journal |
| issn | 1689-1392 |
| language | English |
| last_indexed | 2024-03-08T22:36:56Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj.art-f3a8e2e65bde47ad87a020da9b0bba262023-12-17T12:24:22ZengBMCCellular & Molecular Biology Letters1689-13922023-12-0128112110.1186/s11658-023-00514-0Role of N6-methyladenosine methylation in glioma: recent insights and future directionsChunlin Li0Bowen Li1Hui Wang2Linglong Qu3Hui Liu4Chao Weng5Jinming Han6Yuan Li7Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese MedicineCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese MedicineDepartment of Acupuncture, Zaozhuang Traditional Chinese Medicine HospitalCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese MedicineFirst School of Clinical Medicine, Shandong University of Traditional Chinese MedicineDepartment of Neurology, Renmin Hospital of Wuhan UniversityDepartment of Neurology, Xuanwu Hospital, Capital Medical UniversityKey Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong UniversityAbstract Glioma is the most pervasive intracranial tumor in the central nervous system (CNS), with glioblastoma (GBM) being the most malignant type having a highly heterogeneous cancer cell population. There is a significantly high mortality rate in GBM patients. Molecular biomarkers related to GBM malignancy may have prognostic values in predicting survival outcomes and therapeutic responses, especially in patients with high-grade gliomas. In particular, N6-methyladenine (m6A) mRNA modification is the most abundant form of post-transcriptional RNA modification in mammals and is involved in regulating mRNA translation and degradation. Cumulative findings indicate that m6A methylation plays a crucial part in neurogenesis and glioma pathogenesis. In this review, we summarize recent advances regarding the functional significance of m6A modification and its regulatory factors in glioma occurrence and progression. Significant advancement of m6A methylation-associated regulators as potential therapeutic targets is also discussed.https://doi.org/10.1186/s11658-023-00514-0N6-methyladenosine methylationRNAGliomaNeurogenesis |
| spellingShingle | Chunlin Li Bowen Li Hui Wang Linglong Qu Hui Liu Chao Weng Jinming Han Yuan Li Role of N6-methyladenosine methylation in glioma: recent insights and future directions Cellular & Molecular Biology Letters N6-methyladenosine methylation RNA Glioma Neurogenesis |
| title | Role of N6-methyladenosine methylation in glioma: recent insights and future directions |
| title_full | Role of N6-methyladenosine methylation in glioma: recent insights and future directions |
| title_fullStr | Role of N6-methyladenosine methylation in glioma: recent insights and future directions |
| title_full_unstemmed | Role of N6-methyladenosine methylation in glioma: recent insights and future directions |
| title_short | Role of N6-methyladenosine methylation in glioma: recent insights and future directions |
| title_sort | role of n6 methyladenosine methylation in glioma recent insights and future directions |
| topic | N6-methyladenosine methylation RNA Glioma Neurogenesis |
| url | https://doi.org/10.1186/s11658-023-00514-0 |
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